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@MRKHvoice @STILLTish @janeclarejones IVF is still more likely to fail than it is to succeed, 1 in 4 known pregnancies ends in miscarriage (70% including biochemical pregnancies). If we could get infertile females (like me) pregnant first that would be progress...
@MRKHvoice @STILLTish @janeclarejones ...if male pregnancy means trans men then there is no medical mystery there as that's an individual with a female reproductive system conceiving and sustaining a pregnancy
@MRKHvoice @STILLTish @janeclarejones Uterine transplants in women with AUFI (absolute uterine factor infertility) is a relatively simple matter of plumbing, from a medical perspective - it's transplanting a bit that should be there, but isn't
@MRKHvoice @STILLTish @janeclarejones For a trans woman who is a biological male, it is NOT simply a matter of plumbing. That's a profoundly mechanistic view of the body. Pregnancy involves so many complex biological systems, & so much of implantation & sustaining a pregnancy is poorly understood
@MRKHvoice @STILLTish @janeclarejones The endocrine & immunological factors are immense - even the interplay between a male foetus and the maternal body has an immunological impact theguardian.com/science/2006/j…
@MRKHvoice @STILLTish @janeclarejones Immunological factors have an enormous impact on implantation and miscarriage, as the immune system has to basically give an embryo a free pass and not reject it as a foreign body - reproductive immunology is poorly understood in fertile biological females as it is
@MRKHvoice @STILLTish @janeclarejones And that's before even considering musculoskeletal factors of the ligaments & pelvis shape that would be needed to sustain a pregnancy. The idea that now uterine transplants have been successful that means trans women getting pregnant is just around the corner is laughable
@MRKHvoice @STILLTish @janeclarejones Success rates for IVF have certainly improved since Louise Brown was born 40 years ago, but the cumulative success rate of 3 cycles of IVF is only 45-53%. That's in 40 years. In biological females. nice.org.uk/news/blog/the-…
@MRKHvoice @STILLTish @janeclarejones Rates of miscarriage and stillbirth are still extraordinarily high and are largely unknown. I've taken part in Tommy's miscarriage research, who are trying to better understand what causes pregnancy loss. We know so very very little. tommys.org/our-organisati…
@MRKHvoice @STILLTish @janeclarejones Tommy's do incredible work and frankly anyone who wanted to fund research into male pregnancy would do well to fund their research into female pregnancy, as we simply don't understand what causes the loss of so many babies tommys.org/our-organisati…
@MRKHvoice @STILLTish @janeclarejones Reproductive immunology is controversial but theories about alloimmune factors of DNA mismatches between male & female partners in implantation dysfunction & recurrent miscarriage aren't matters of simple plumbing haveababy.com/fertility-info…
