Thread by @HermelinMD

Thursday #Blooducation schmooze on the topic of anti-G antibodies as they pertain to pregnancy and #HDFN. 👇🏽Follow the thread below to get capture the key points🅰️🅱️🆎🅾️🤰🏽👶🏽 Let's get started. #PathTweetorial

🚧The anti-G antibody can cause confusion because it presents on a panel as a combination of anti-D and anti-C, sometimes called "anti-CD", when truly, an anti-D may not be present at all 🤦🏽‍♀️
⁉️What type of patients can form an anti-G?

Anti-G antibodies are formed when an Rh(D) neg person, generally rr (dce/dce ) individuals, are exposed through transfusion/pregnancy, to either C+, D+ or C+D+ blood. That's because the G-Ag is always found on C+ & mostly on the D+ RBCs. This is what the panel would look like👇🏽

Which is the most common type of blood transfused that can lead alloimmunizatin and formation of anti-G antibodies in an Rh(D) negative person?

🙌🏽Good job! The answer lies in frequency. Usually RhD negative individuals are (hopefully) provided RhD negative blood, but may be transfused with Rh(D) negative, C+ blood = rr' phenotype. Also, a person may be exposed through trauma or pregnancy, most commonly ROr = Dce, dce.

This issue is particularly important in pregnancy. Why?
1.) Recognize and monitor anti-G antibodies which can cause HDFN
🌟2.) Proper adminstration of RhIG to pregnant women who are at risk of RhD alloimmunization (women who do not have anti-D antibody)

Ask yourself: Does the RhD negative pregnant mother have TRUE anti-D antibodies? If no, we provide RhIg to prevent future alloimmunization and risk of HDFN. If yes, we DO NOT provide RhIg to prevent alloimmunization, because it already took place.

🧐To learn more about this complicated topic on anti-G antibodies, please check out this outstanding 🖥️blog by @bloodbankguy that takes you through a step-by-step discussion on the subject. 👉🏽bbguy.org/2016/06/17/wan…

#Blooducation colleagues: Please share your experiences and pearls on anti-G antibodies below. 🙏🏽Thank you!
@bullock_tom @LFKTinyDancer @ThatLabChick