Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Amy Proal, PhD Profile picture
@microbeminded2
Dec 11, 2019 • 3 tweets • 3 min read • Read on X
This pilot study found that certain strains of #bacteria in Parmesan cheese (which are derived from cattle gut, milk and the local #environment) can colonize + persist in the guts of people who consume the cheese on a daily basis: nature.com/articles/s4146… ImageImage
2/ The findings suggest that globalization must be impacting gut #microbiome composition in a growing # of people 👉 Think how an average USA supermarket imports cheese + other #foods from around the globe, meaning people are often consuming an “international” mix of #organisms
3/ I wonder if, in some people, the #gut is not prepared for influxes of so many different global organisms, and/or lacks #immunity against certain strains 👉 If yes, that cld partly explain why people who “eat locally” (their #food comes from the same area) sometimes feel better

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Amy Proal, PhD

Amy Proal, PhD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @microbeminded2

Amy Proal, PhD Profile picture
Jun 15
If you are a patient that meets #ME/CFS and #PEM criteria, info on the specific #infections or exposures that led to onset or exacerbation of your symptoms is of major importance. That info will help you pursue personalized treatment.
2/ That is because many of the infections you've sustained may still be #persisting in your body - in your tissue or nerves. These persistent infections can cause PEM symptoms by driving #mitochondrial dysfunction, blood vessel/perfusion issues, or #vagus nerve dysfunction
3/ If your symptoms started - or were exacerbated - by a #herpesvirus infection, such viruses persist in your system for life. Thus, treatment with herpesvirus #antivirals (e.g. the Pridgen Protocol which uses valacyclovir and Celebrex) has helped certain ME/CFS patients improve
Read 14 tweets
Amy Proal, PhD Profile picture
Jun 8
Jawdropping data here showing dozens of #viruses - many rarely even discussed or tested for on a regular basis - in sewage collected from wastewater in multiple USA cities. The viruses are identified via unbiased sequencing that can identify any viral genome in the samples.
2/ Because the viruses are being identified in wastewater it's possible that some viruses are harbored by animals - for example cattle or birds - whose feces end up in the wastewater
3/ However, it's likely that most of the viruses being shed into wastewater come from infected humans. Viruses like the enteroviruses A, B, C, D68, Rhinoviruses A, B, C, Rotaviruses, Noroviruses, Rotaviruses, Mastadenoviruses, Adenoviruses, Rhinoviruses, Influenza viruses, etc.
Read 33 tweets
Amy Proal, PhD Profile picture
Feb 20
Glad to have contributed to this new preprint. We found that some PVS participants had higher levels of circulating spike protein compared to controls.

This parallels #LongCovid where persistence of the SARS-CoV-2 #virus in patient tissue may also cause spike to periodically leak into blood
2/ For example, this study found #SARS-CoV-2 proteins including spike up to 1 year post-COVID in up to 25% of people tested. But identified spike was not a result of the COVID vaccine, since nearly all study participants had not received the vaccine: thelancet.com/journals/lanin…
3/ The same team also found SARS-CoV-2 spike protein encoding double-stranded RNA in LongCovid #gut tissue almost 2 years post-#infection. Such RNA is produced during active viral replication and thus wld not be vaccine derived: science.org/doi/10.1126/sc…
Read 7 tweets
Amy Proal, PhD Profile picture
Feb 16
Today I write for the @latimes: Long COVID is solvable, but we need more clinical trials.

These include trials of drugs to clear #SARS-CoV-2 reservoirs: small pockets of the virus - or parts of the virus - that can persist long-term in people’s bodies.

latimes.com/opinion/story/…
2/ We are living in an epidemic of chronic #disease, with a growing number of pesticides, chemicals and food additives implicated in the declining health of Americans.
3/ Since 2019, another factor has been at play as well: The #SARS-CoV-2 virus has driven a huge increase in chronic #health consequences, broadly referred to as long COVID.
Read 30 tweets
Amy Proal, PhD Profile picture
Feb 11
Our new Viewpoint is out! We draw from treatment strategies in HIV, Hep C & other infections, to detail key considerations for #LongCovid clinical trials targeting persistent #SARS-CoV-2. These include combination trials of drugs that target both the virus and the immune system: authors.elsevier.com/a/1kayZ5E-UogX…
2/ To maximize these trials, we must develop validated #biomarkers to detect persistent virus or protein in accessible fluids like blood & saliva. Such biomarkers will allow targeted recruitment of participants w/ viral persistence into trials - helping trials to meet endpoints
3/ This persistence biomarker development - and the #LongCovid trials of immunotherapies, monoclonals, antivirals and other drugs delineated in our Viewpoint - are huge opportunities for the #biotech space. Agile, action-oriented agencies like @ARPA_H should also rapidly engage
Read 4 tweets
Amy Proal, PhD Profile picture
Apr 13, 2024
@BaszkoM @RorPreston @polybioRF That is not correct. We are working very hard on ME/CFS projects in addition to LC, and almost every day we work with teams to determine how more of our LC projects can be pivoted to ME/CFS in the future
@BaszkoM @RorPreston @polybioRF 2/ ME/CFS projects include this collaborative study determining immune activity, microclotting and other infectious parameters in ME/CFS patients with peripheral neuropathy: polybio.org/projects/immun…
@BaszkoM @RorPreston @polybioRF 3/ This study of neuroinflammation via PET imaging and imaging to document changes in cognitive control (brain fog) in ME/CFS: polybio.org/projects/5272/
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(