There is an urgent need to generate effective vaccine against #SARSCoV2. This is such an important topic, and many agencies/labs/companies are working on it. I want to open up this discussion here. Let's unite towards this goal.

Pls RT, chime in with your insights/thoughts.

Learning from previous #CoV studies, what is likely to be the correlate of protection? What vaccine approaches generate best neutralizing antibody (Ab)? How quickly does #CoV generally mutate away from Ab-mediated recognition?

What would be a good preclinical model to test vaccine efficacy against #CoV? How well do antibodies to previous #CoVs cross-react against other members including #SARSCoV1, #MERSCoV and #SARSCoV2?

BTW, if you are interested in doing research on #SARSCoV2 vaccines, pathogenesis and related topics, @NIAIDFunding released this last week 👇🏽

@NIAIDFunding I just read this timely and useful summary of various companies and academic labs developing #COVID19 vaccines in @BioCentury. Adding this to my thread.

WHO mapping out COVID-19 vaccines

@NIAIDFunding @BioCentury For researchers interested in studying #SARSCoV2, @CDCgov has deposited viral isolates to BEI Resources 👇🏽


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More from @VirusesImmunity

7 Feb
How well do various vaccines reduce severe COVID disease & death? Awesome @YaleMed students, @dariusdariusdar, @ChaneyKalinich, @Larson_HaleighT & Caroline Valdez put together summary tables from vaccine trials. Remarkable ability of vaccines to ⬇️ severe/lethal COVID! 🧵(1/n)
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Top 10 most downloaded articles in 2020 includes our review in the @AnnualReviews Virology - “Seasonality of Respiratory Viral Infections” by @MiyuMoriyama et al! It’s free to download:

Here let’s highlight other relevant pieces on the same topic (1/n)
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1) ⬇️ Temperature
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10 Jan
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Being at @yale, the birthplace of #SalivaDirect and everything saliva bc of awesome colleagues like @awyllie13 @NathanGrubaugh @VogelsChantal et al, we had access to both saliva and nasopharyngeal (NP) samples from the same patients to do direct comparisons. (3/n)
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1 Jan
My first tweet of 2021 is going to be about 1 dose vs. 2 dose vaccine. I have tweeted in the past of the immunological advantages of a 2 dose vaccine. However, given the enhanced transmission variants on the rise, we need a modified strategy. (1/n)…
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Inspired by this tweet by @TheMenacheryLab, I reached out to the wonderful colleagues at the @serimmune to see if the other mutations found in the B.1.1.7 variant would evade antibody responses generated by the wild type #SARSCOV2. (1/n)
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26 Dec 20
What aspects of antibody responses determine the outcome of #COVID19? In this new preprint by @carolilucas @sneakyvirus1 et al., we found that the early timing of antibody response (before 14 days of symptom) in infected person is key to recovery. (1/n)…
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