1/6 Two days ago @NebulaGenomics announced the $299 genome in partnership with @TheBgiGroup. I was curious about the history of this cost so I looked historical price points curated by @genome_gov. Here are some results:
@NebulaGenomics @TheBgiGroup @genome_gov 2/6 While the initial funding to create the first draft of the human genome was $2.7 billion, the actual price to sequence the final draft of the human genome was closer to ~100 million. This point is commonly missed. See here genome.gov/about-genomics… 
@NebulaGenomics @TheBgiGroup @genome_gov 3/6 If pricing were to scale with the inverse of Moore’s law, we would be paying $186,061 today for a human genome. That is 622x more expensive than the $299 genome offered by @NebulaGenomics. This reduction in cost, over 20 years, is equivalent a $9.06 cheaper genome per minute.
@NebulaGenomics @TheBgiGroup @genome_gov 4/6 With historical estimates the cost of a human genome today should be $534 today, that is 1.8x more expensive than what @NebulaGenomics is offering. Are they taking a loss? Have new technology? Great deal with @TheBgiGroup?
@NebulaGenomics @TheBgiGroup @genome_gov 5/6 Looking at the lower hull and fitting a trend-line to those points we estimate that by 2040 the price of a human genome should be $386. $87 more expensive than today.
@NebulaGenomics @TheBgiGroup @genome_gov 6/6 If you want to explore this data yourself, all of the code is available via a @GoogleColab notebook: colab.research.google.com/github/sbooesh…
