The team whose modelling estimates advised Cobra are presenting their modelling. They modelled controlled spread and realised 250,000 would die. Now advise stronger intervention to suppress - but no idea how long it will need to be in place. #coronavirusuk
Updates came after seeing Italy - and proportion of patients in ICU
"We will be in quite different world for year or more"

Neil Ferguson - Imperial.

There is no end to major measures until we get vaccine.
"The idea of controlling a virus like this while having a vaguely functioning society has put us in uncharted territory."
"We were expecting herd immunity to build. We now realise it’s not possible to cope with that. " - Prof Azra Ghani
Best guess 35-50k people infected.
(currently infected)
"Closing schools would have some effect at reducing transmission. Closing schools on its own will have a significant effect on healthcare capacity.

If I was to guess, it is quite likely to happen"
"The aim now is not to slow the rate of growth of cases, but put the epidemic in reverse. Hopefully there will be tens of thousands of deaths. Maybe just a few thousand."
Neil Ferguson:

"The only exit strategy is really vaccination or other forms of innovative technology."

We are going to be in lockdown for quite some time.
We are in this for the *very* long haul
More on how long this should last
More from Azra Ghani, Imperial

"The trade off is, do we accept that there could be deaths now? Or do we try and push things out to the future in the hope that something else will come along? We think the latter is the right way to do it."
I have never been in a press conference like it.
Paper abstract

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More from @whippletom

Feb 15
Just some more thoughts on this, because I don't think people realise quite how big our testing infrastructure has become - or how wide. 1/x
First, testing itself. Currently, we are PCR testing about 300,000 people a day, and recording over a million including lateral flows. This is us on a quiet day
Other countries have done more when pushed, but none do so at this level this consistently. But this is just the front end of our testing infrastructure.
Read 18 tweets
Feb 3
I'm going through this paper by Johns Hopkins economists, that assesses the efficacy of lockdown in the US and Europe - and concludes it was essentially useless.

I'd love thoughts on something I've found, which may well be my misinterpretation 1/x sites.krieger.jhu.edu/iae/files/2022…
The study is a meta-analysis, combining other previous between-country comparisons. To produce the combined estimate, they take 18,000 studies, exclude all but a handful and then pool their findings. Image
Looking at the weighting, it actually seems to be based almost entirely on one study. So rather than being a meta-analysis it is really a recapitulation of that study, by Chisadza et al Image
Read 11 tweets
Dec 8, 2021
Briefing on Pfizer/biontech neutralisation studies has begun. 19 or 20 seras (why don't they know which?!)

1/x
Stark - v stark - difference between two and three doses. Three looks almost as good.
Is this analagous to delta? It escaped one dose, but was pinned down with two. Omicron escapes two, but cornered by three.
Read 11 tweets
Nov 26, 2021
For people who talk about boys crying wolf...actually the boy has been pretty restrained regarding variants. Remember iota or kappa?

This one is different

thetimes.co.uk/article/b30489…
Those other variants in full:

1. Alpha, the Kent variant. In November of 2020, amid a national lockdown, cases started rising in Sheppey. Everyone thought it was just people in Sheppey doing Sheppey things. Turned out it wasn't. It was a 50 per cent more transmissible variant
(here is the definitive report:reuters.com/investigates/s…)

Verdict: scariant
Read 11 tweets
Jul 26, 2021
And on this edifying note, I'm signing out of twitter. I'm off on much-delayed paternity leave. I was meant to do it last year, but decided to delay until the pandemic was over. Not tweeting until the autumn.

In the meantime, everyone is cross. Here is covid stuff that's great:
The covid dashboard, coronavurus.data.gov.uk, by @Pouriaaa and @statsgeekclare and doubtless loads of others. Clear, invaluable and does exactly what it should.
The variant technical group, with @meera_chand , @jcbarret, @PHE_uk and others. Absolutely stunning. Basically mathematical witchcraft, calculating all the crucial efficacy and transmissibility data on the fly, amid massive uncertainty google.com/url?sa=t&sourc…
Read 13 tweets
Feb 7, 2021
Demographics of the South African study into Oxford vaccine
Criteria for mild or moderate cases
Neutralization data - immune responses "similar if not better"
Read 14 tweets

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