Prof. Akiko Iwasaki Profile picture
Mar 18, 2020 7 tweets 5 min read Read on X
There is a lot of talk about #herdimmunity. Vaccination is the only safe way to achieve it. In the absence of vaccine, we need to practice #SocialDistancing. @BioRender made this amazing infographic to explain how a hypothetical virus spreads through the population. (1/n) Image
Herd immunity describes indirect protection from infectious disease when a large % of people in a population is immune to the pathogen. The % threshold of immune individuals required for #herdImmunity depends on how contagious (R0) the pathogen is. (2/n)

pbs.org/wgbh/nova/arti… Image
#herdimmunity can be achieved either through vaccination or through natural infection. However, vaccination is the only safe way to achieve it. It also depends on how effective & long lasting immune response induced by the vaccine or infection to confer #herdimmunity. (3/n)
In the absence of vaccination, the virus will spread quickly and kill people, while the recovered will be immune (top). With #SocialDistancing, many more will survive. Some become immune (middle). If a vaccine is introduced, most will survive and become immune (bottom). (4/n) Image
With #COVID19 with its lethality rate, the only safe way to achieve herd immunity is through vaccination. That is why it is so important to develop effective vaccines. Trying to achieve herd immunity through natural infection will put millions of lives in danger. (5/n) Image
Even with quarantine of high risk groups, exposure of 'low risk' group to #COVID19 will result in 0.2% risk of death among 10-39 year old, 0.4% for 40-49, 1.3% for 50-59 year old. The risk for hospitalization is a lot higher than this. (6/n)

weforum.org/agenda/2020/03… Image
Any questions related to the graphics, @BioRender team will be happy to address them. They also made the templates available so anyone can download and edit them. Thank you for all you do for our community, @BioRender 🙏🏽🙏🏽🙏🏽 #scicomm (7/n)

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More from @VirusesImmunity

Aug 2
Introducing BEACON (Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles) to stimulate mucosal immune responses against genital #HSV infection. Awesome work led by @sachinbhag, who designed and developed BEACON to guide T and B cells (1/)
biorxiv.org/content/10.110…
The BEACON nanoparticle is composed of CpG ODN (TLR9 agonist) and CXCL9 (chemokine). When applied to the vaginal mucosa, the recruitment of antiviral T cells is achieved with minimal local inflammation - much more potent than CpG or CXCL9 separately. (2/) Image
Intramuscular vaccines do not promote mucosal immunity. BEACON can be used as a local adjuvant to boost HSV-2 gD- or gB-specific T and B cells, preventing not only disease/death but also blocking viral load in both vaginal tissue and dorsal root ganglia (🚫latency)(3/)👇🏼 Image
Read 4 tweets
Jul 17
A fascinating new study by Vishnu Shankar et al. @stanfordimmuno shows that oxidative stress is a shared characteristic of ME/CFS and Long COVID in lymphocytes due to inability to clear reactive oxygen species. This happens in sex-specific manner. (1/)
pnas.org/doi/abs/10.107…Image
Females show higher mtROS levels and insufficient antioxidant levels, while males show mitochondrial lipid oxidative damage. While the reason for this is unclear, it may explain the sex differences in lymphocyte dysfunction we see in PAIS in general. (2/)
science.org/doi/10.1126/sc…
ROS-targeting therapies were tested. Metformin treatment in vitro showed some impact on CD4 T cell proliferation. I suspect that other therapies to induce autophagy/mitophagy might also benefit restoration of T cell phenotype. #LowDoseRapamycin 👇🏼 (3/)
polybio.org/projects/long-…
Read 4 tweets
May 16
Published today! Victoria Bastos, @KerrieGreene_ et al found two distinct immunotypes of ME/CFS based on the cerebrospinal fluid analysis. Great collaboration with @MBVanElzakker @microbeminded2 and the Bragée clinic in Sweden. (1/)
academic.oup.com/jimmunol/artic…
This is perfect timing as Victoria will present these data at the @polybioRF symposium today. (2/)

polybio.org/spring-2025-sy…Image
Based on cerebrospinal fluid cytokines, we identified two clusters of ME/CFS patients. Cluster 1 had elevated matrix metalloproteinases & many cytokines compared to cluster 2. Other than older age (Cluster 1), clinical presentation of these clusters was similar. (3/) Image
Read 5 tweets
May 13
Published today📣
Our nasal booster in the "Prime & Spike" vaccine works without adjuvants (which are needed to induce adaptive immunity but also cause inflammation). @Kwon_Dongil @tianyangmao @BenIsraelow et al. asked how this is possible. (1/)
nature.com/articles/s4159…
Prime & Spike is a vaccine strategy that leverages preexisting immunity primed by conventional vaccines to elicit mucosal IgA and T cell responses that prevent COVID infection and transmission in rodents. The nasal booster is simply the spike protein (2/) science.org/doi/10.1126/sc…
Our new study shows that the nasal spike protein booster converts lymph node memory B cells into IgA-secreting cells in the lung with the help of memory CD4 T cells. Ag-specific CD4 T cells replace all the necessary functions of adjuvants without nonspecific inflammation! (3/)
Read 5 tweets
May 10
This prospective observational study led by @connorbgrady @bornali_27 @SilvaJ_C @hmkyale examined the impact of the primary COVID-19 vaccination on the symptoms and immune signatures of 16 people with #longCOVID. Here is what we found 👇🏼 (1/)

nature.com/articles/s4385…
This study asked: Does COVID vaccination improve symptoms of long COVID? If so, is the improvement due to robust T and B cell responses leading to the clearance of the viral reservoir? If not, is there an immune feature that predicts worsening of LC? (2/)
The self-reported impact of vaccination was variable. Of the 16 long COVID patients, 10 felt better, 3 had no change, and 3 had worse health (1 hospitalized) 12 weeks after vaccination. Both physical and social effects of symptom burden appeared to decrease after vaccination. (3/)Image
Read 6 tweets
Feb 20
Our preprint on post-vaccination syndrome is out. We studied immune signatures and examined spike protein in the blood of people who have developed chronic illnesses after COVID-19 vaccination. (1/) medrxiv.org/content/10.110…
Vaccines have saved countless lives and inspired me to become an immunologist. While generally safe, some people experience adverse effects, including Post-Vaccination Syndrome (PVS). Studying PVS is crucial for improving patient care and enhancing vaccine safety & acceptance. (2/) pubmed.ncbi.nlm.nih.gov/37986769/
To explain the study and results, @MalloryLocklear wrote this excellent summary. (3/)
news.yale.edu/2025/02/19/imm…
Read 6 tweets

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