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Rare syndrome in #COVID19 positive children reported globally.

100+ cases of the unusual illness linked to Covid-19 have emerged in at least 6 countries resembling #KawasakiDisease including the US where several cases emerged in DC in past 24 hours.
Doctors reporting cases of rare but potentially lethal inflammatory syndrome in children that appears to be linked to coronavirus infections.

-100+ cases in 6 countries
-doctors in Britain, US, France, Italy, Spain & Switzerland investigating .theguardian.com/society/2020/a…
#US In less than 24 hours, Children's National Hospital in #DC has admitted several children w/ COVID-19 experiencing a constellation of symptoms that resemble "Kawasaki disease," rare inflammatory syndrome typically affecting children under the age of 5.
abcnews.go.com/Health/childre…
From April 26th

"Abdominal pain and gastrointestinal symptoms “have been a common feature” of the illness, as has cardiac inflammation.

Doctors have been asked to urgently refer any patients showing signs of these." independent.co.uk/news/health/co…
"United Kingdom & Italy have in recent days sounded an alarm about a new disease with possible links to novel coronavirus. France has more than a dozen cases of children with inflammation around the heart" -via @ProMED_mail
promedmail.org/promed-post/?i…
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COVID19
@V2019N
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⚠️Two coronavirus-infected people died in Santa Clara County on Feb. 6 & Feb. 17, the medical examiner revealed Tues, making them first documented COVID-19 fatalities in the US.

Until now, the first fatality was believed to have occurred in Kirkland, Wash., on Feb. 29
Officials previously had said the first Silicon Valley death was March 9. But the Santa Clara County medical examiner revealed Tuesday that people who died Feb. 6, Feb. 17 and March 6 also died of COVID-19.
“These 3 individuals died at home during a time when very limited testing was available only through the @CDCgov Testing criteria set by the CDC at the time restricted testing to only individuals with a known travel history and who sought medical care for specific symptoms.”
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COVID19
@V2019N
Immunity after any infection can range from lifelong and complete to nearly nonexistent. So far, however, only the first glimmers of data are available about immunity to SARS-CoV-2, the coronavirus that causes Covid-19. -@mlipsitch
nytimes.com/2020/04/13/opi…
Much of our understanding of coronavirus immunity comes not from SARS or MERS, which have infected comparatively small numbers of people, but from the coronaviruses that spread every year causing respiratory infections ranging from a common cold to pneumonia.
After being infected with SARS-CoV-2, most individuals will have an immune response, some better than others. That response, it may be assumed, will offer some protection over the medium term — at least a year — and then its effectiveness might decline.
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COVID19
@V2019N
New preprint: Factors associated with hospitalization and critical illness among 4,103 patients with #COVID__19 in NYC

-analysis of all patients w/ Covid-19
-primary outcomes hospitalization & critical illness
-identify risk factors for adverse outcomes
Among 4,103 Covid-19 patients, 1,999 (48.7%) were hospitalized, of whom 981/1,999 (49.1%) have been discharged home, and 292/1,999 (14.6%) have died or were discharged to hospice.
Of 445 patients requiring mechanical ventilation, 162/445 (36.4%) have died. Strongest hospitalization risks were age ≥75 years (OR 66.8, 95% CI, 44.7-102.6), age 65-74 (OR 10.9, 95% CI, 8.35-14.34), BMI>40 (OR 6.2, 95% CI, 4.2-9.3), and heart failure (OR 4.3 95% CI, 1.9-11.2).
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