Another significant advance on the structural biology front for #SARSCoV2 today: cryo-EM for its polymerase (RdRp) complex along w/ that of remdesivir w/ RNA bound RdRp, the mechanism for its inhibition of replication
@ScienceMagazine science.sciencemag.org/content/early/… via @hholdenthorp
@ScienceMagazine science.sciencemag.org/content/early/… via @hholdenthorp
This is the 6th structural biology (SB) #SARSCoV2 (virus & antibody)paper @ScienceMagazine in < 2 months. Elucidation of these structures are pivotal to smart design of a drug, monoclonal Ab & vaccine, no less understanding of the 1 drug w/ efficacy so far.
SB is rockin' it!
SB is rockin' it!
You can say that again:
"We do know the cause of COVID-19. Down to the atoms."
—@hholdenthorp
The prior 5 #SARSCoV2 structural biology papers
@ScienceMagazine: spike protein, ACE2 receptor, main viral protease, an antibody, & its polymerase
blogs.sciencemag.org/editors-blog/2…
"We do know the cause of COVID-19. Down to the atoms."
—@hholdenthorp
The prior 5 #SARSCoV2 structural biology papers
@ScienceMagazine: spike protein, ACE2 receptor, main viral protease, an antibody, & its polymerase
blogs.sciencemag.org/editors-blog/2…
