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Undercounting #COVID19 deaths: why it's so important to factor in all-cause mortality:
Italy
bmj.com/user/login?des… @bmj_latest (just published)
USA nytimes.com/2020/05/13/opi… @nytopinion @NickKristof w/ @rafalab
Fixed link for the @bmj_latest bmj.com/content/369/bm…
Funny to get these multiple replies with @NickKristof's piece from yesterday
—when I put the link and print of it in my post
—and that is the whole point:
We are undercounting deaths.....not just the US, everywhere
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Eric Topol
@EricTopol
Why have active cigarette smokers been consistently shown to have relative protection from #COVID19?
A new paper @Dev_Cell shows a substantial increase of ACE2 expression that is dose-dependent, by @JSheltzer @CSHL @joans @Google and colleagues
cell.com/action/showPdf…
Some have questioned my assertion of cigarette smoking offering relative protection
There are several references, but here is the latest @TheLancet and many more like this
thelancet.com/pdfs/journals/…
Let me add I’d be the last person in the world to support cigarettes or find anything that supports their use. There’s a paradox here with the new @Dev_cell paper. Others have suggested nicotine interactions. A lot more to learn on this topic
Read 4 tweets
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Eric Topol
@EricTopol
The historic, botched operation
@NewYorker,masterful by Barry Bliss
Correction: I botched Barry's last name. It's Blitt.
The operation failed.
And so did the drug.
@PostOpinions
Read 4 tweets
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Eric Topol
@EricTopol
Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍
cell.com/cell/fulltext/…
There have been 2 prior reports (both @ScienceMagazine) isolating neutralizing antibodies, each from a single patient w/discovery of key epitopes +cryo-EM structure. This report goes well beyond those w/ sc-RNA seq of B cells *60* patients, model efficacy, best nAb paper to date
Here are the links to the 2 prior @ScienceMagazine papers:
science.sciencemag.org/content/sci/ea…
science.sciencemag.org/content/early/…
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
Read 3 tweets

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