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Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍
cell.com/cell/fulltext/…
There have been 2 prior reports (both @ScienceMagazine) isolating neutralizing antibodies, each from a single patient w/discovery of key epitopes +cryo-EM structure. This report goes well beyond those w/ sc-RNA seq of B cells *60* patients, model efficacy, best nAb paper to date
Here are the links to the 2 prior @ScienceMagazine papers:
science.sciencemag.org/content/sci/ea…
science.sciencemag.org/content/early/…
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
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Eric Topol
@EricTopol
The Remdesivir placebo-controlled randomized trial data.
We've eagerly awaited the data; now published @NEJM nejm.org/doi/pdf/10.105…
Significant benefit for 27% ⬇️time to recovery, across all subgroups except those on a ventilator/ECMO, death reduced 30% (95% CI 0.47, 1.04; NS)
The section about changing the primary endpoint and informing the NIAID. This seems perfectly above board, well done
The benefit in patients who were not ordinal scale 6/7 (on non-inv or invasive ventilation at baseline) is impressive. Safety issues were less with the drug v placebo
Overall remdesivir is a safe and effective drug for #COVID19 patients with lower respiratory tract involvement.
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Eric Topol
@EricTopol
A note about the world's worst super-spreader events:
3 of the worst were from churches
South Korea (Feb 9/16) >5,000 cases
France (Feb 17) > 2,500 cases
US (March 10) 53 cases
Here are another >220 cases spread through church events, none as large as the 3 above, from @gmknght's remarkable spreadsheet tally
docs.google.com/spreadsheets/d…
This April church event in Sacramento, California, led to at least 71 cases
capradio.org/articles/2020/…
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Eric Topol
@EricTopol
Elegant, extensive #3D structural biology of #SARCoV2's polymerase, cryo-EM mapping its replication machinery, and remdesivir binding, published @CellCellPress today
cell.com/cell/fulltext/…
This work follows on unparalleled velocity of high quality structural biology of #SARSCoV2 and neutralizing antibodies (from patients). It will help in drug, antibody and vaccine devp't. If you can't keep all the "NSPx's straight, the @NEJM figure might help!
Yet another paper @nature today
nature.com/articles/s4158… on the #SARSCoV2 polymerase!
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