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New meta-analyisis estimates: (1) proportion of truly asymptomatic #COVID19 cases and (2) proportion of #SARS_CoV_2 transmission from asymptomatic or pre-symptomatic individuals [1/3] medrxiv.org/content/10.110…
Overall, proportion of people who become infected with #SARS_CoV_2 and remain asymptomatic through the course of infection estimated to be 15% [2/3]
40-60% of #SARS_CoV_2 infections are the result of transmission from pre-symptomatic individuals. The contribution from asymptomatic individuals seems to be much smaller estimated at around 6% (but wide confidence intervals). [3/3]
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Franz Wiesbauer, MD MPH
@medmastery
Great review in the @NEJM about epidemiologic models and their pitfalls. nejm.org/doi/full/10.10…

Pitfall #1: We don‘t know how many people have been truly infected. [1/4]
Pitfall #2: We remain uncertain about the extent of protective immunity, which greatly impacts the course of the epidemic.

Pitfall #3: What’s the extent of transmission and immunity among ppl with no or minimal symptoms (and children) [2/4]
Pitfall #4: It‘s very hard to measure and model contact rates between susceptible and infectious ppl nodt only under phys distancing but also in various reopening scenarios. [3/4]
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Franz Wiesbauer, MD MPH
@medmastery
@JohnsHopkinsSPH measured the prevalence of serious psychological distress in 1468 adults aged 18 years or older in Apr 2020 & compared it with an identical measure from the 2018 National Health Interview Survey (NHIS). Thread (1/6)

jamanetwork.com/journals/jama/…
In April 2020, 13.6% of US adults reported symptoms of serious psychological distress, relative to 3.9% in 2018. That’s a 3.5-fold increase. (2/6)
Age: symptoms of psychological distress were highest among young adults aged 18 to 29 years. Distress decreased with increasing age in 2020. Previously, no effect of age on distress. (3/6)
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Franz Wiesbauer, MD MPH
@medmastery
Short THREAD on chloroquine:

Mar 17: French doctor Didier Raoult et al publish a paper suggesting that hydroxychloroquine and antibiotic azithromycin could be effective against the disease. (1/6)

medrxiv.org/content/10.110… Image
Several public figures like @elonmusk jumped on the bandwagon promoting the drug based on results from basic research (not randomized trials, not even observational studies). (2/6) Image
And, obviously, the President also chimed in...(3/6) Image
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