Short THREAD on chloroquine:

Mar 17: French doctor Didier Raoult et al publish a paper suggesting that hydroxychloroquine and antibiotic azithromycin could be effective against the disease. (1/6)

medrxiv.org/content/10.110… Image
Several public figures like @elonmusk jumped on the bandwagon promoting the drug based on results from basic research (not randomized trials, not even observational studies). (2/6) Image
And, obviously, the President also chimed in...(3/6) Image
Recent evidence shows surge in chloroquine prescriptions, likely due to off-label prescriptions for COVID-19 and “President Trump’s support of the drug”. Fills increased from 2208 in 2019 to 45 858 prescriptions (that’s a 1977.0% increase!) (4/6)
jamanetwork.com/journals/jama/… Image
We now have strong evidence (study of 96,032 individuals) that chloroquine with or without a macrolide likely do not help and might even cause more harm than benefit. Studies are still ongoing and stronger evidence will accrue. (5/6)

thelancet.com/journals/lance… Image
So if you have large followings and think you must join the scientific discussion, pls adhere to the same stringent principles as real scientific journalists do and don't promote potentially harmful drugs (@realDonaldTrump & @elonmusk). (6/6) #firstprinciples Image

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