Discover and read the best of Twitter Threads about #sars_cov_2

Most recents (24)

1. The @Ligandal antidote to #SARSCoV2 has been getting a lot of attention, but some people are having difficulty understanding how it works and what makes it so promising, so here's a Saturday explainer.
2. There have been many questions about immunity to human coronaviruses and whether vaccines will prompt a long-term protective immune response to #SARS_CoV_2. @edyong209 does a great job of explaining the vagaries of immunity.

theatlantic.com/health/archive…
3. @Ligandal opted for an approach that doesn't rely on the human immune system to be effective.

The #SARSCoV2 virus infects human cells via the ACE2 receptor. Here's a computer simulation with the ACE2 receptor in red and the virus in green.

Big bully 🦠
Read 16 tweets
Venga, abro un pequeño hilo de #obesidad, #Covid_19 y #Ejercicio Vamos!!!

Recientemente un metanálisis habla de la obesidad como el factor de riesgo más prevalente y la enfermedad respiratoria como la más predictiva.

pubmed.ncbi.nlm.nih.gov/32721533/
La mayoría de los trabajos de #SARS_CoV_2 han mostrado datos relacionados con el IMC como predictor de riesgo. Ya sabíamos que la #obesidad afecta a nivel a muchos niveles, pero sobre todo a nivel respiratorio y metabólico
Además se ha visto que en personas con #obesidad, la resistencia a la insulina y la hiperactividad del sistema renina-angiotensina-aldosterona (RAAS), implica peores resultados en la infección por #Covid_19
ncbi.nlm.nih.gov/pmc/articles/P…
Read 21 tweets
.@NYTimes has done great data journalism on #SARS_CoV_2, filling gaps left by an incompetent US federal response but their recent coverage re: schools is tipping towards sensationalism & divergence from data... nytimes.com/interactive/20…
This coverage is totally freaking people out once again with the idea that preschool-aged children are super-spreaders, which is NOT TRUE! 2/
There’s a lot we don’t know but the overwhelming weight of global data from household, school, & pop-surveillance studies indicates that small children are less likely to contract & spread this virus. Not zero risk but surprisingly low. dontforgetthebubbles.com/the-missing-li…
Read 20 tweets
A #SARS_CoV_2 data analysis by modelling.
Five European countries with highest fatalities to date, plus Sweden.

(This updates previous modelling tweeted on July 7th.) ImageImage
Note: This modelling is an analytical tool & not assumption-based predictive type. Minimise assumptions & complexity. Let reality lead the model, not vice versa. Model is compartmental, with additions & mods. Data is used to tests the hypotheses modelled & find parameter values.
for info: An example of previous related analysis from a couple of months ago:
Read 4 tweets
I just want to be clear: while I understand and have similar frustrations with turnaround times for #COVIDー19 testing, I'm afraid the angst is falling on the laboratories...and I do not feel that is fair or appropriate. (Small thread)
The clinical laboratory is full of living, breathing, intelligent human beings. The work takes skill and time. Often, labs are understaffed and there has been a shortage of trained clinical lab scientists FOR A WHILE. There are only so many tests a person can crank out in a day.
Even if a lab has all the staff they need, there's only so much testing that can be done when a) your instruments are full b) you cannot get the supplies you need to run these tests. Seems like many people think labs have unlimited access to very expensive instruments...nope.
Read 8 tweets
Now that our SalivaDirect FDA EUA application for #SARS_CoV_2 diagnostics has been submitted, here is a sneak-peak at our validation results. medRxiv pre-print is forthcoming, but twitter is faster 😉

Overview: saliva w/o special tubes > no RNA extraction > dualplex PCR

1/n
2/n
About SalivaDirect ➡️ covidtrackerct.com/about-salivadi…

Papers & Protocols ➡️ covidtrackerct.com/saliva-related…

SalivaDirect Results ➡️ covidtrackerct.com/salivadirect-r…

NBA validation study "Swish" ➡️ covidtrackerct.com/swish/
3/n
We validated SalivaDirect with multiple reagents & platforms to:
-make it available to more labs
-avoid specific supply chain bottlenecks
-keep costs down.

We'll provide specific information on how to conduct bridging studies to validate additional reagents/equipement
Read 10 tweets
Potser els virolegs ambientals (o jo) no hem explicat bé això de #coronavirus i temperatura. Són els virus sensibles a les temperatures d'estiu (i a la insolació i la radiació associada)? Sí. Són els #coronavirus en general i #SARSCoV2 sensibles a temperatures de 30-37ºC o més?
Taxativament sí, no els hi poso els articles; al meu TL els poden trobar. Però, és un procés q necessita el seu TEMPS (hores, dies) i afecta bàsicament a superfícies i fomites i també als exsudats....però les #fomites MAI van ser un vector principal de transmissió de #SARSCoV2...
i els exsudats, les microgotes, no tenen massa temps per patir les condicions ambientals si...som a 30 cm del company/a a la terrassa del bar, o dins; o a una barbacoa, o ens toquem, abracem, i ens exhalem l'un a l'altre...aquí no hi ha temperatures q hi jugui cap paper pq no...
Read 5 tweets
1/ Thread: Deeper dive into this fascinating autopsy series from the @davidadorward and colleagues with @COVID_ICECAP @EdinburghUni:

Tissue-Specific Tolerance in Fatal #Covid_19
- N= 11 patients
- Tissue Samples = 37 sites each (23 specific to respiratory tract) → 407 samples
2/
- Mean Age: 77
- 10 (90.9%) patients male
- 4 (36.3%) patients received invasive mechanical ventilation

- #SARS_CoV_2 RNA was detected across ALL sampled organs and tissue sites
- Most frequent = Respiratory tract, GI tract, Heart, muscle
- Less frequent = Liver, Kidney
3/ Organ testing by several methods:

- #SARS_CoV_2 RNA
- Multiplex PCR mapped to SARS-CoV_2 genome
--> Presence of S protein evaluated on select PCR positive tissues
- Histological analysis of multiple tissues
Read 20 tweets
Nueva información que sugiere que el SARS-CoV-2 Sí se puede transmitir por el aire (y que la OMS ha actualizado hoy) como antes se creía improbable (como la OMS informaba hasta hoy). Abro hilo.
Igual cabe mencionar como introducción que la la OMS está "perdiendo credibilidad de le gente" por varios "cambios de opinión" a lo largo de la Pandemia como fueron las recomendaciones de EPP o el uso de Hidroxicloroquina, por ejemplo.
La respuesta que le daría a estas personas es que cuando se trata de algo nuevo, la credibilidad se basa en evidencias y estas a veces demoran en ser comprobadas, reproducibles y estandarizadas. Muchos conocimientos obvios de hoy quizá en un tiempo fueron poco claros antes.
Read 30 tweets
A #SARS_CoV_2 data analysis by modelling.
Five European countries with highest fatalities to date, plus Sweden.

(This updates previous modelling of June 30th.) ImageImage
Note: This modelling is an analytical tool & not assumption-based predictive type. Minimise assumptions & complexity. Let reality lead the model, not vice versa. Model is compartmental, with additions & mods. Data is used to tests the hypotheses modelled & find parameter values.
Read 3 tweets
.@monaeltahawy has said, FUCK NORMAL, in a short video that rightly pins the pandemic on the status quo that made it possible. Going back to normal isn't what we need. 1/
My friend and colleague @akapczynski and I have talked about a new politics of care that is anything but normal, relies on overturning the political status quo I've lived with all my life. 2/ bostonreview.net/politics/gregg…
I've been thinking about Virginia Woolf's "Jacob's Room" lately. It's a story about someone who is not coming back, a country where as Leonard Woolf said, "people are ghosts." 3/ gutenberg.org/cache/epub/567…
Read 21 tweets
Chlorhexidine (CHX) is very much effective against #SARS_CoV_2. The earlier notion that CHX may not work on the 'novel coronavirus' is outdated. Old studies had used very low conc. New evidence shows CHX effective against #2019ncov at 0.05% conc. #COVID19

researchgate.net/publication/34…
Study shows a single rinse with Chlorhexidine (CHX) mouthwash reduces SARS-COV-2 viral load in saliva for 2 hrs. Suggests CHX rinse to prevent #Covid19 spread via droplets.
Rinse 10 ml of 0.20% CHX for 30 sec

Pubmed: pubmed.ncbi.nlm.nih.gov/32449329/

Full article: ncbi.nlm.nih.gov/pmc/articles/P…
A single rinse with Chlorhexidine (CHX) mouthwash reduces SARS-COV-2 viral load in saliva for 2 hours. Rinse & gargle 10 ml of 0.20% CHX for 30 sec.
This evidence can be applied for prevention of #2019ncov spread in clinical & community settings. #COVID19 pubmed.ncbi.nlm.nih.gov/32449329/
Read 4 tweets
@profchrisham @ONS There are 4 Pillars. Pillar 1 labs test the Swab by a technique called RT PCR, to see whether the patient has current infection with #SARS_CoV_2. This test is delivered by NHS and PHE labs. Pillar 2 labs do the same but are delivered by the Private Lighthouse labs. 1/n
@profchrisham @ONS 2/n The Pillar 1 labs declare their testing rate, & are a correct number of tests processed. Pillar 2 labs declare the tests processed AND the tests they have sent out. Test sent out should not be counted. Pillar 2 total tests are misleading. gov.uk/guidance/coron…
@profchrisham @ONS 3/n @profchrisham Pillar 3 testing is for antibody tests, to see whether you have had #SARS_CoV_2. These are mostly processed in NHS labs and the numbers are correct. But it is meaningless to add them to the number of RT PCR tests
Read 7 tweets
⚠️⚠️Communiqué de presse de la @SPILF_ et de toutes les instances de maladies infectieuses et tropicales représentant l'ensemble des médecins infectiologues français

"Une crise sanitaire ne justifie pas qu’on dise, ou qu’on fasse, n’importe quoi !"

Contact presse en DM
👇 1/n
Nos instances, représentant les médecins spécialisés en maladies infectieuses en France, souhaitent dénoncer les affirmations sans fondement qui ont été diffusées sur des chaînes de radio-télévision nationales au cours des derniers jours.

2/n
Elles sont d’autant plus graves qu’elles sont l’œuvre d’un médecin, chef de service dans un hôpital. Selon ses propos, 25 000 morts liées à la COVID-19 auraient pu être évitées en France si la combinaison hydroxychloroquine et azithromycine avait été prescrite massivement.

3/n
Read 17 tweets
Excited to announce our new study to develop and validate an inexpensive and sensitive saliva-based method for #SARS_CoV_2 testing in partnership with the @NBA.

Will be led by @awyllie13, @hmkyale, & myself from the @YaleSPH side.

usatoday.com/story/sports/n…
We'll be using our new #SalivaDirect protocol developed by @VogelsChantal + @DougBrackney. We'll have sensitivity data and a study design overview available on our website soon.

protocols.io/view/salivadir…
Our study has 2 aims:

On the lab side, we are preparing #SalivaDirect for FDA EUA, and are validating with many different vendor reagents to drive down costs and not add supply chain bottlenecks. We are not seeking to commercialize any aspect. Our goal is to get this to $1/test
Read 9 tweets
🔥Voilà un thread afin de ne pas avoir à répéter tout le temps la même chose sur la recherche médicale thérapeutique pendant #COVID19 #SARS_CoV_2 #pandemic

👇👇
1/ Les infectiologues cliniciens n'attendaient pas de ttt antiviral permettant une amélioration "spectaculaire" pr une maladie aiguë virale sévère (cf dengue, zika, chik, grippe), il était donc nécessaire d’évaluer rigoureusement et d’espérer un ttt un peu efficace et non toxique
2/ Il existe de nombreux candidats repositionnés qui ont été utilisés et testés et ce dès le début de la pandémie : #lopinavir/#ritonavir, #remdesivir, #hydroxychloroquine, #interferon ß pour n’en citer que quelques-uns
Read 35 tweets
New meta-analyisis estimates: (1) proportion of truly asymptomatic #COVID19 cases and (2) proportion of #SARS_CoV_2 transmission from asymptomatic or pre-symptomatic individuals [1/3] medrxiv.org/content/10.110…
Overall, proportion of people who become infected with #SARS_CoV_2 and remain asymptomatic through the course of infection estimated to be 15% [2/3]
40-60% of #SARS_CoV_2 infections are the result of transmission from pre-symptomatic individuals. The contribution from asymptomatic individuals seems to be much smaller estimated at around 6% (but wide confidence intervals). [3/3]
Read 4 tweets
1. It's been frustrating to witness events unfold entirely as some predicted. My heart goes out to all those who've lost loved ones in the #COVID19 pandemic & those who are still suffering with illness.
2. In this March 2nd piece I warned a lethal pandemic was inevitable, the illness would not be mild, immunity would be uncertain, and if we didn't act quickly we'd be trapped with a high infection rate and a broken economy.
freemarketconservatives.org/the-government…
3. We've made all the wrong choices and ended up exactly where I'd feared. So what now? It's clear some governments have given up. Lockdown is too hard. Test, track, isolate is too hard. The economic pain is too severe. They plan to let the virus run through their populations.
Read 22 tweets
1) Der super saubere #Sars_Cov_2-#PCR-Test von #Drosten, kann auf das Erkältungsvirus #Coronavirus #CoVOC43 kreuzreagieren. Die Möglichkeit von falsch-positiven Tests deshalb, ist wochenlang bekannt. #CoVOC43 kommt auch bei Tieren vor.

#TestetdieTests

instand-ev.de/System/rv-file…
2) Gerade hier wird die ganze Glaubwürdigkeit von bestimmten Experten und sogenannten "#Faktenchecker|n" überdeutlich. Dass keine falsch-positiven Fälle bekannt sind, heisst nicht, dass es keine gibt, bei >95/98% Spezifität.
correctiv.org/faktencheck/me…
3) Bei einer #Sars_CoV_2-Prävalenz(Infektionsdichte) von ca.1% o. darunter, wie zeitweise vermutet, ist das genauso, als wenn man mit einem guten Fernglas (PCR-Test) versucht, im dichten Nebel, scharfe Umrisse (Viren) zu erkennen. Es funktioniert nicht!
Read 6 tweets
'Rajasthan'....Why NOT getting some limelight in #COVID19 context? At a Glance:
- 5119/mil tests
- 66% recovery rate
- 31% active cases
- 2.23% mortality
- 3% growth rate, which needs to be down further.
The state is doing fine so far!! #rajasthancoronaupdate Image
States w/ 1000+ #Covid_19 cases: Sample tested until 31 May & Positive rate(%)
#Maharashtra 14.63%, highest
Trouble: Delhi, Telangana, Bihar & Gujarat, need intervention.
Excellent: Andhra, Karnataka, J& K positive rate below 1.5%.
Good: Rajashthan, Haryana, UP #COVID19India Image
As on 1 June, #TamilNadu added 1162 new cases. Positive rate stands at 9.77%, highest in last 7 days. Recovery 57%, Active cases 42%, mortality is just 0.79%. #TamilNaduCoronaupdate #IndiaFightsCoronavirus @Sheks65 @pibchennai
Read 18 tweets
THREAD: (1) A thought-provoking study by @Baric_Lab using reverse genetics and autopsy specimens demonstrates nasal ACE2 binding greater than in respiratory tract.

cell.com/cell/fulltext/…

#covid19 #coronavirus
(2) The nose contained highest percentage of ACE2 expressing cells. ACE2 levels waned in more distal bronchiolar & alveolar regions.
(3) ACE2 expression patterns were paralleled by high SARS-CoV-2 infectivity of nasal epithelium with marked reduction in distal lung (bronchioles & alveoli).
Read 13 tweets
1️⃣خلص كثير من الباحثين والمتخصصين في علم الفيروسات والأوبئة من خلال الدراسات الحديثة
التي أجريت خلال فاشية كورونا #SARS_CoV_2
إلى عدة استنتاجات و تصورات
يتبع ..
2️⃣ ينصح ان تتخذ الجهات الحكومية وغير الحكومية من هذه الاستنتاجات العلمية منصة لانطلاقتها في تنظيم اماكن و طريقة سير أعمالها في مرحلة تخفيف الحظر الكلي والعودة التدريجية للحياة العملية الجديدة
يتبع ..
3️⃣ ومما خلصوا إليه :

١ ) العوامل الرئيسية لإنتشار الفيروس

🛑التقارب لمدة طويلة (~ ١٥ دقيقة)
🛑البيئة المغلقة
🛑البيئة المكتظة المزدحمة
🛑البيئة الخالية من التهوية
🛑تجمعات الأصدقاء
🛑التجمعات العائلية

يتبع ..
Read 11 tweets
1/ THREAD: Memorial Day in a Pandemic

I often struggle with #MemorialDay. With the calls for celebration and happiness on this day. For BBQs and summer fun.

Because nothing about this day is happy.

This day is about #grief. About tragedy. About #death and loss.

🇺🇸 😔 😢
2/ Above all, it is a day of RESPECT. Because Americans gave their lives in service to protect the citizens and country of the United States.

The lives they previously dreamt of were cut short. And that selfless gift of life is one of the highest honors to serve your country. Image
3/ But their husbands and wives will never kiss their spouses again. Their children will never hug their mothers or fathers again. It doesn’t change the visceral grief of parents losing their children to #prematuredeath. #memorialdayweekend2020 Image
Read 31 tweets
Let's #UnPack (some facts) before we #FlyAgain. Lots of threads lately about if it is #Safe2Fly & how to #FlySafe. Here are a couple with really good information.
This article by @ernstkc & @BeamerPaloma provides good guidance to #MinimizeRisks. Great ideas for #HandHygiene while travelling, pick a #WindowSeat to minimize 6' sphere exposure, beware of neighbors #droplets. theconversation.com/should-you-fly…
@j_g_allen does a great job explaining hierarch of control to reduce risks, encouraging masks, discusses other risks besides the flight while traveling. Importantly, encourages airlines to deploy gate #ventilation since ventilation is poor at taxi & gate. washingtonpost.com/opinions/2020/…
Read 15 tweets

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