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If you blinked this week, you might have missed that #CRISPR went to very fast vfCRISPR: genome editing at much higher resolution in time and also in space
science.sciencemag.org/content/368/64… @ScienceMagazine by @yliu_jhu @taekjip @HopkinsMedicine
Summary of this work with the double entendre of light
science.sciencemag.org/content/368/64…
by Darpan Medhi and Maria Jasin @sloan_kettering
with @ScienceVisuals
A video of photoactivation genome editing at work
A precise path towards understanding DNA repair pathways
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Eric Topol
@EricTopol
How did Japan, with much older demographics than the US, and higher density of people, have 7 deaths per million compared to >300 deaths per million for the US?
And only 133 cases/million vs 5385/million?
an update
#ClusterBusting is a big factor. Anticipating the 80/20 Pareto principle.
Japan's "Patient Cluster Countermeasure Group" diligently traced all 61 cluster and superspreader events wwwnc.cdc.gov/eid/article/26…
see also @kakape's excellent thread
Behavior and culture is another important factor, as assessed in this new paper. Better adherence to mitigation measures than the US.
journals.plos.org/plosone/articl… @PLOSOne
Read 4 tweets
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Eric Topol
@EricTopol
What we've been missing, below the surface, about #COVID19. The focus has been on confirmed cases, hospitalizations and deaths. But there's so much more we've been learning. United States data here
2. Let's start with the excess deaths, attributed to non-covid19 diagnoses. Here's a sampling to show excess causes of death in March-May in many places was likely inaccurately categorized. The estimates of actual covid-19 deaths suggests an additional >40,000 fatalities
3. Now the missed cases from lack of testing availability, mild/moderate symptoms that did not lead to testing, false negatives tests, and those never having discernible symptoms. Asymptomatics comprise at least 30% those infected
acpjournals.org/doi/10.7326/M2… @AnnalsofIM
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Eric Topol
@EricTopol
Zero out.
The way to beat #COVID19.
For cases, Iceland, New Zealand and Taiwan
For preventing fatalities, 10 standouts
the above 3, plus Australia, Japan, Estonia, Norway, Thailand, South Korea, Uruguay, and Vietnam
Vietnam, a country of 97 million, with zero deaths
And an economy expected to grow (yes grow) 5% this year during a massive global recession
An explanation axios.com/vietnam-corona… @axios by @DavidLawler10
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