Thread by @EricTopol

Now with ~1,000 children and adolescents with multi-inflammatory syndrome in children (MIS-C), it can be considered a new disease. Today new @NEJM reports and an editorial on its status. I've made a summary of some key points to start

Here is the USA report of 186 patients with locations of diagnoses, organ involvement and labs
nejm.org/doi/full/10.10…

The outstanding editorial, by Michael Levin
nejm.org/doi/full/10.10…
a report from New York State to follow later

Here is the New York State report today of 99 patients
nejm.org/doi/full/10.10…
with clusters of manifestations (the high % skin, GI, cardiac, neurologic, KD=Kawasaki's), therapy used, and associated diagnoses

So there's a paradox of the vast majority of children and adolescents that are spared from either susceptibility or adverse outcomes; yet a rare subgroup with MIS-C. A commentary in today's @TheLancetRheum explores the immunologic considerations
thelancet.com/action/showPdf…