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Just published @nature, the unique, in-depth, serial assessment of >2,300 people in a town in Italy for #SARSCoV2. nature.com/articles/s4158…. Besides suppression of the outbreak, it is highly instructive that *42%* were asymptomatic infections, & differentiated from presymptomatic
The viral load of the people without symptoms was very similar to those with symptoms
It established, in a limited number of people, that asymptomatic carriers of #SARSCoV2 could infect other individuals. The frequency of this transmission is not known, and likely is low.
Symptom-free carriers
Which is why Sunday's @nytimes front page was so apropos and why wearing a mask is essential 😷
And congratulations to @IDorigatti @ConniCiavarella @ginacd1 @l_cattarino @mathModInf @UniPadova @imperialcollege and all their colleagues for this careful and extensive work, which has been illuminating in so
many respects
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Eric Topol
@EricTopol
It's another very bad day in the US top #COVID19 spreading states
1. California, which never had its case numbers down before reopening, is in very rapid growth
wsj.com/articles/how-s…
very good explainers:
@jtemple technologyreview.com/2020/06/30/100…
@Bob_Wachter Image
2. Texas and Arizona summarized here by @VaughnHillyard and @JeremySWallace Their hospitalizations at peak yesterday tell you this isn't just about positive tests
@COVID19Tracking ImageImage
3. Florida. This graph.
Still waiting to see their hospitalization and ICU data. Someday. Image
Read 6 tweets
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Eric Topol
@EricTopol
When we don't measure important stuff.
A thread about the immune response to #SARSCoV2
1. Since serology/IgG can be readily measured, this is what is conventionally used to assess an individual's response
That's a very incomplete picture
cell.com/trends/pharmac… Image
2. Just because T cell repertoire isn't measured, except for research purposes, doesn't mean it's not important. Very important. Like in this recent @SciImmunology paper that showed the #SARSCoV2-specific T cell response in patients with ARDS
immunology.sciencemag.org/content/5/48/e… Image
3. So many studies have reported IgG, IgM but provide no insight on T-cell mediated immunity, no less serially assess this over time. A good example is this excellent recent paper @NatureMedicine in asymptomatic patients nature.com/articles/s4159… Image
Read 8 tweets
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Eric Topol
@EricTopol
Now with ~1,000 children and adolescents with multi-inflammatory syndrome in children (MIS-C), it can be considered a new disease. Today new @NEJM reports and an editorial on its status. I've made a summary of some key points to start
Here is the USA report of 186 patients with locations of diagnoses, organ involvement and labs
nejm.org/doi/full/10.10…
The outstanding editorial, by Michael Levin
nejm.org/doi/full/10.10…
a report from New York State to follow later
Read 5 tweets

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