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There's been an explosion of new knowledge on the T cell response to #SARSCoV2 today, filling in big gaps. Overall very reassuring
@Nature nature.com/articles/s4158… by @Anto_Berto @bertoletti_lab
@ScienceMagazine science.sciencemag.org/content/early/… by @Penn_IFI
both reviewed in prior posts
More on the @ScienceMagazine paper, interview with @EJohnWherry by @CaroMT
Back to the @nature paper is the intriguing connection to animal coronaviruses (specifically response to nsp7) for cross-reactivity, which expands that of common cold coronavirus (also previously noted) and raises questions about past animal-> human transmission
I wish the media would stop harping on the disappearing antibody story (@medRxiv preprint) and acknowledge these 2 T cell papers today that provide substantial reassurance.
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Eric Topol
@EricTopol
Just published @nature on T cell response to #SARSCoV2:
All 36 recovered patients had CD4 and CD8 responses to nucleocapsid protein, and SARSCoV1 had cross-reactive T cells, along with uninfected. nature.com/articles/s4158…
This important work comes in wake of the preprint this week on waning antibodies and it's especially encouraging to see the extensive T cell activation vs #SARSCoV2
You can see that fortunately the T cell response to #SARSCoV2 resembles and overlaps with SARSCoV1 and unlike the common cold coronaviruses
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Eric Topol
@EricTopol
"The lack of data speaks a lot to whose lives we value and whose lives we don’t”—@DrRichardBesser @RWJF sciencemag.org/news/2020/07/h… on the pathetic lack of testing and relevant data for underrepresented minorities @ScienceMagazine by @KellyServick
New @CDCgov report on #COVID19 deaths
cdc.gov/mmwr/volumes/6…
Blacks and Latinos are not only over-represented among those who died, but at younger ages, and deaths among younger people were more likely to be at home or emergency department
That's @DrRichBesser (I had wrong twitter handle)
If only he or @DrTomFrieden were running @CDCgov right now
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Eric Topol
@EricTopol
Maybe a wrong turn might catch someone's attention
Or that it took only 28 days to get 1 million more cases
(1st million 95 days, 2nd million 43 days)
Or that each day is a new record in cases with >62,000 yesterday
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