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Very sad to note that today is the first day since May 29th (>6 weeks ago) there were more than 1,000 American #COVID19 deaths
@COVID19Tracking
> 8 weeks (not 6, my mistake)
We haven't seen this level of US #COVID19 hospitalizations since the April 15th peak
While attention has focused on Texas, Arizona, and Florida, many news states have hit new hospitalization and death numbers recently or today. Including South Carolina, Mississippi, Georgia, Tennessee and Idaho
For the big 4 states today (by population or spread/highest positive test rate, AZ still >23%)
Less new cases trend for Florida, Arizona
Less hospitalization in Arizona but climbing to new heights in the other 3
High death numbers and rising in FL, TX, AZ
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Eric Topol
@EricTopol
On the 4 published Phase 1/2 #SARSCoV2 vaccine programs
(@moderna_tx @UniofOxford @Pfizer CanSino)
1. None have shown prevention of infections or disease; they show an antibody response, some T cell response, and preliminary safety. Can't be emphasized enough.
2. We have no idea about durability. The virus is only ~8 months old!
3. Only 2 of these programs presented specific T-cell response data (perhaps a proxy for longer-lasting protection):
Pfizer/BioNTech program CD4+ in 34/36 patients, CD8+ 29/36 patients
Moderna mostly only CD4+
References for T cell data
Pfizer/BioNTech
medrxiv.org/content/10.110…
Moderna nejm.org/doi/suppl/10.1…
Read 4 tweets
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Eric Topol
@EricTopol
On #diabetes, glucose control, #COVID19, #SARSCoV2
A new @Cell_Metabolism paper on the mechanism for uncontrolled glucose and severe covid19
cell.com/action/showPdf…
A new @TheLancetEndo review goes deep on why there are worse outcomes thelancet.com/journals/landi…
The one thing I was surprised about in the review was lack of mention of the affinity of #SARSCoV2 to pancreatic islet β cells. This is thought to be another mechanism for new onset #T1D; there have been many cases reported and an ongoing registry
Summary of #SARSCoV2 affinity to ACE2, direct pancreas hit and COVIdiab registry
nejm.org/doi/full/10.10…
Read 3 tweets
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Eric Topol
@EricTopol
Our conversation with Tony Fauci was highly informative, and inspirational. A summary of key points of the podcast and commentary w/ @cuttingforstone @Medscape medscape.com/viewarticle/93…
1. The #SARSCoV2 virus in unique
2. That's 20-40% of people who get infected and never show symptoms. More likely in young. Who don't understand they are propagating the pandemic
"Usually a virus that is good enough to kill you would make almost everybody at least a little bit sick."
3. The chronic "long covid" post-viral symptoms of #COVID19 are common, understudied to date.
"And it's extraordinary how many people have a postviral syndrome that's very strikingly similar to myalgic encephalomyelitis/chronic fatigue syndrome."
Read 13 tweets

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