With so much more we've learned since, it's time for an update
They are a big part the unascertained cases 1/x
acpjournals.org/doi/10.7326/M2…
@ScrippsRTI @danieloran @scrippsresearch 3/x
We even had a letter to the Editor requesting our paper be retracted, something I have not ever experienced before 4/x
The dynamics of the Wuhan transmission of their near ~60,000 cases. You can see the breakdown of presymptomatics vs "unascertained"--no tests, no symptoms, or such mild symptoms ("paucity) not recognized by person
nature.com/articles/s4158… 5/x
medrxiv.org/content/10.110…
Asymptomatic in 71% of residents and 92% of staff 6/x
42.5% did not develop symptoms; the viral load was the same as the people with symptoms 8/x
Immunology
A study @NatureMedicine showed a blunted immune (IgG) & inflammatory response in ASx
nature.com/articles/s4159…
9/x
jamanetwork.com/journals/jamai… @JAMAInternalMed
nytimes.com/2020/08/06/hea… @apoorva_nyc 10/x
link.springer.com/content/pdf/10…
11/x
No studies for other organs yet reported; no serial studies to determine if/when these abnormalities fully resolved 12/x
wwwnc.cdc.gov/eid/article/26…
but the % is unknown, requires culture of virus, sequencing proof fully define chain of transmission 13/x