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1/ Today I was asked by #ATS forum: “Are antipsychotics ever indicated for #delirium in ICU patients?”

My reply: “YES, to control hyperactive delirium symptoms to avoid respiratory suppression...👀 example...

#MedTwitter #MedEd #MedStudentTwitter #pulmcc #TipsForNewDocs
2/ HYPERACTIVE DELIRIUM & antipsychotics

Answer cont: For example, in a patient with CHF or COPD who needs BIPAP to avoid intubation but has marginal BP and HR so perhaps can’t tolerate an alpha-2 agonist. In such patients, antipsychotics might be just the right medication...
3/ HYPERACTIVE DELIRIUM & antipsychotics

Answer cont...to help patient get over claustrophobia of CPAP mask. This approach is fine as long AS LONG AS we know we are NOT reducing delirium, rather converting positive sympt of anxiety/delirium into calm toleration of resp support.
4/fin HYPERACTIVE DELIRIUM & antipsychotics

For data see our NEJM MIND-USA trial: bit.ly/2AWg1TJ

Also read letter: bit.ly/3gJzGX4 where we answer this specifically to @MarkOldhamMD
Here are hyperactive & hypoactive #delirium subgroup figures from NEJM MIND-USA trial since others were asking. At the bottom is my conclusion slide including examples of when I still use antipsychotics in clinical practice and why.

#MedTwitter #TipsForNewDocs #pulmcc
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