, 12 tweets, 7 min read
My Authors
Read all threads
Encephalopathy vs Delirium 🧠: 1/11

#COVID19 has profoundly amped this malady for millions...

ICU Doc asked: “Wes, what’s the difference between delirium & encephalopathy?” I chuckled, “Got an hour?” & distilled it down in 2 min.

#medtwitter #pulmcc #meded #tipsfornewdocs
Encephalopathy vs Delirium: 2/

20 years ago we started publishing our ICU Delirium papers. The biggy was in JAMA after being rejected by NEJM’s main Neurologist Reviewer because “we used the term delirium & not encephalopathy.”

So this confusion is STILL going on…
Encephalopathy vs Delirium: 3/

To help with this nomenclature problem, Arjen Slooter led us & we published this 2020 delphi study and paper endorsed by 10 med societies.

Intens Care Med:
bit.ly/3eLODWJ

#medtwitter #medstudenttwitter #pulmcc #tipsfornewdocs
Encephalopathy vs Delirium: 4/

Bottom Line:
Use delirium & encephalopathy interchangeably ONLY for “quiet” delirium. Add Coma & you have major spectrum of acute brain dysfunction in #ICU & hospitalized “confused pts.”
Encephalopathy vs Delirium: 5/

Delirium is a broader term than encephalopathy & includes BOTH hyperactive & hypoactive acute brain dysfunction.

EG:
CAM-ICU positive w/ high RASS is hyperactive delirium.

CAM-ICU positive w/ normal or low RASS score is hyooactive delirium.
Encephalopathy vs Delirium: 6/

Hyperactive Delirium =
🤔 DTs. Agitation. 90% “withdrawal” from drugs like Alcohol, Benzos, & Narcotics

Hypoactive delirium = Encephalopathy. It’s QUIET delirium, manifested by an ABSENCE of symptoms & analogous to a petit mal seizure.
Encephalopathy vs Delirium: 7/

Interesting History:
<1% of papers use BOTH terms delirium & encephalopathy in same study. 99% pick one or other. Neurology literature pushes “encephalopathy” for hypoactive delirium & “delirium” just for hyperactive state = TERMINOLOGY SPLITTERS
Encephalopathy vs Delirium: 8/

As opposed to neurology, the geriatric & psychiatry literature uses delirium for BOTH hypoactive and hyperactive forms of acute brain dysfunction. They are TERMINOLOGY LUMPERS.

There you have it!
Encephalopathy vs Delirium: 9/

BILLING: One thing driving the ongoing use of “encephalopathy” is that ICD-9 CODING is more geared to that term than to “delirium.” Delirium coding is a work in progress. So as usual, 💰is at the heart of much.
Encephalopathy vs Delirium: 10/

The problem with using “encephalopathy” for hypoactive states is that ALL valid & reliable delirium tools (eg, 4-AT) call someone “delirious” at BOTH hyper- & hypoactive states of acute brain dysfunction. So documentation gets tricky/messed up.
Encephalopathy vs Delirium: 11/Fin

BONUS: Delirium duration is a predictor of what 4 relevant outcomes?

1. Death
2. Length of stay
3. Cost of Care
4. Acquired dementia

Friends, this matter! Monitor patients for #delirium. Talk & fix it on rounds via Dr. Dre & A2Fbundle
Another way of looking at this question/topic of whether pts have delirium or encephalopathy & are these words interchangeable?

Delirium= clinical phenotype
Encephalopathy= patholophysiology / cause

see paper by @MarkOldhamMD

bit.ly/30XJwQh
Missing some Tweet in this thread? You can try to force a refresh.

Keep Current with WesElyMD

Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!