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EXPLORER-HCM Efficacy and Safety of #Mavacamten in HCM Presented by Dr. Olivotto
♥️Meds for HCM very limited and don't prevent progression or reverse it
♥️HCM results from too many cross bridging and this drug prevents this
#EXPLORER #ESCCongress
EXPLORER-HCM Efficacy and Safety of #Mavacamten:
Study & Characteristics &Results as below:
🔺251 Patients (largest trial in HCM)
🔺97% completed study
🔺Improved functional score and improved NYHA class
🔺⬇️post exercise gradients
🔺⬇️ resting and valsalva gradient
EXPLORER-HCM Efficacy and Safety of #Mavacamten
#ESCCongress
🔺Complete response in 27% as what is seen in septal myomectomy
🔺Very safe & well tolerated drug
🔺Question if beta blockers poorly tolerated in HCM & perhaps time to get rid of this as a med in HCM
#EXPLORER-HCM #Mavacamten
📌75% of HCM patients saw a reduction in LVOT gradients
📌Need longterm data to know if effect on SCD & 56% had complete relief of symptoms
📌#Mavacamten very well tolerated & improved functional capacity
Is it time for this drug? Or need more data?
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Dr. Martha Gulati “Masks are the New Black”
@DrMarthaGulati
#ESCCongress #LoDoCo2 Results #LBCT
Colchicine also a winner of @escardio 2020
This study was building on COLCOT results in secondary prevention in patients w/ chronic CAD
🔺5522 patients enrolled
🔺Randomized to Colchicine 0.5 mg vs Placebo
🔺Excluded advanced CKD, HF, valve ds ImageImageImageImage
Characteristics of #LoDoCo2 #ESCCongress
🔺90% of patients tolerated medication
🔺Mostly men (84%)
🔺Most had prior revascularization
🔺 Most well treated ImageImageImageImage
Results of #LoDoCo2 show dramatic effect of colchicine in these patients with chronic CAD
♥️30% reduction in treatment arm for Primary Outcome
♥️28% ⤵️ in MACE
♥️subgroup analysis shown
#ESCCongress #residualrisk #colchicine #inflammation ImageImageImageImage
Read 5 tweets
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Dr. Martha Gulati “Masks are the New Black”
@DrMarthaGulati
#SCCT2020 Limitations of Stress Testing/Imaging in Women from @Heart_SCCT
♥️Too few 💃 enrolled in studies based on prevelance esp in CAD and HF
♥️NIH/Gov funded the worst enrollees of women! We need to change that
#scct2020 Sex Considerations for Stress Testing need to be considered
♥️ Sn/Sp of tests based on doing Cath for Obstructive CAD: these are NOT false positives! so these numbers are outdated IMHO
♥️every imaging modality has + &- to consider when imaging women
#SCCT2020
♥️Prognostic implications of CAC in women vs men well established: CAC >300: 💃 do worse
♥️Nonobstructive disease more prevalent in 💃
♥️ Implications on imaging women ultimately
Read 7 tweets
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Dr. Martha Gulati
@DrMarthaGulati
Although #COVID19 is horrific and changed everything for all of us including #acc20 #WCCardio I just wanted to take a second to reflect on a few things.
1. Social distancing has not been isolating in this day & age. We have been able to gather strength from being in touch #SoMe
2. We have been able to be resourceful & use technology to stay connected with colleagues worldwide, our families and friends. Never before had I felt connected to the world despite being slightly alone physically
3. Did we ever have happy hours together before this, virtually?
4. Did you ever call your parents or siblings so often that you ran out of things to catch up on? Sometimes we have sat in silence and that has been nice. Or watch movies from afar but together. ♥️
5. Working together via @zoom_us has been better than just quick call, text, email
Read 8 tweets

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