Thread by @weatherindia

Russia's #COVID19Vaccine Found Safe in Early Human Trials: Study

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#RussianVaccine

(📸: IANS)

💉Russia last month registered the "Sputnik V", becoming the first country to approve a COVID-19 vaccine.

However, the country faced criticism for approving a vaccine before completion of Phase-3 trials.

💉According to the study, published in The Lancet, the researchers enrolled 76 healthy adult volunteers (aged 18-60 years) for the two Phase-1 and Phase-2 studies, 38 people in each study.

💉In Phase-1 of the study, two groups of nine volunteers received one dose of either recombinant adenovirus type 26 (rAd26) vector or recombinant adenovirus type 5 (rAd5), both carrying gene for SARS-CoV-2 spike glycoprotein (rAd26-S & rAd5-S),in frozen form.

#RussianVaccine

💉In Phase-2, another group of 20 healthy adult volunteers in each study received sequential doses of rAd26-S followed by rAd5-S of one of the two formulations.

#RussianVaccine

💉Both formulations of the vaccine were immunogenic in all participants, inducing neutralising humoral and cell-mediated responses, said the study.

💉The study's authors also held that large, long-term trials, including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection.