Breaking: Astra Zeneca halts vaccine trial for safety review due to a serious adverse event. Anonymous source ⁩says volunteer developed transverse myelitis, an inflammatory syndrome that affects the spinal cord and is often sparked by viral infection. nytimes.com/2020/09/08/wor…
The Duration of the safety review is unknown.

The Relationship of the case of transverse myelitis to the vaccine is unknown.
AZ’s vaccine uses a chimpanzee adenovirus to carry the #COVID19 genes into human cells. Although adenovirus are generally harmless,
they “can sometimes trigger their own immune responses, which could harm the patient without generating the intended form of protection.”
It should be noted that:

1. All the vaccines being tested are different

2. This safety review applies only to the AZ vaccine

3. This is a temporary halt at this time

4. Not clear if case is caused by the vaccine

5. I remain optimistic that a vaccine will be successful
We have lots of shots on goal.

Don’t panic.

Remain optimistic 🙏
And yes, I would still volunteer to participate in a vaccine trial.

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More from @CMichaelGibson

16 Aug
#easylikeSundaymorning restoring this badly damaged 300 year old painting from the UK.

There are tears and holes in the canvas and missing paint.

Art restoration brings together my love of restoring things to vitality, painting, science and woodworking / cabinetry making. ImageImageImageImage
I started by patching the tears & holes by using archival acid free glue to add new linen canvas to the back of the painting. ImageImage
You can see how deep the holes are. Lots of layers of gesso, hide glue, & paint had been used 300 years ago. I have filled in the holes with Gesso, a kind of stretchable plaster. I added Lots of small layers until the gesso was just a little higher than the surface of painting ImageImage
Read 20 tweets
27 Jul
I have questions:

1. The follow-up is 2 years after the 2cd dose in the Moderna trial. You cannot enroll if you plan to get another vaccine.

If I get randomized to placebo, & the drug gets approved, will the blind be broken at that time & will I be told I got placebo?
2. Is it ethical to have 15,000 people who were enrolled but received placebo, and don't know that they were randomized to inactive placebo in the context of this and other vaccines being approved?

If they knew, they could elect to get an active vaccine.
3. You could argue that the blind should be maintained to collect 2 year safety & effectiveness data. This is a valid argument to look at long term effects.
But the placebo patients are not being vaccinated, and there is an approved, effective vaccine available.
Is this fair?
Read 20 tweets
18 Jul
Text message from friend in California:

“Could you do a large abstract painting / splatter to match my horse and the colors in my living room”

Me: “It is 90 degrees out & perfect weather to do a splatter painting which allows the layers to dry quickly. I’ll start immediately!”
The first thing we need to do is cover up that sterile soul less white canvas.

Let’s quickly throw down some acrylic paint which dries really quick and allows us to lay down lots of layers ...
20 years of splatter / drip painting has taught me that the key to a good painting is knowing when to STOP ✋

It’s best to stop when you have the right balance of colors, size of drips, balance of shapes and a perfectly randomly random assembly of all the above.
Read 16 tweets
17 Jul
Take 1 or 2 minutes to read about the differences between

Antibodies

&

T Cells

cancercenter.com/community/blog…
Your first line of defense is called "innate immunity".

You were born with this.

This immune "army" attacks infections that you have never been exposed to.

This is your first line of defense.
What would you do if

a) you were losing the battle

b) you had fought this tough enemy before?

You would call in the special ops team who had studied the enemy from previous battles and was fully prepared to defeat them.

This is Acquired Immunity from previous infections.
Read 12 tweets
22 May
Why we might not get a coronavirus vaccine | The Guardian theguardian.com/world/2020/may…
The Dengue fever virus was discovered in 1943 and it was not until last year that the first vaccine was approved

30 years after scientists isolated HIV, there is no vaccine
#COVID19 is a #coronavirus & this type of virus does not tend to trigger long-lasting immunity.

About 1 out of 4 common colds are caused by a coronavirus, but because immunity fades so quickly, people get reinfected year after year.

There is no vaccine to the common cold.
Read 15 tweets
5 May
Thread

Provocative @Circulation article regarding the underlying cause of " #happyhypoxia " associated with #CoronaVirus where people have very low levels of oxygen but don't feel as short of breath like they usually would 1/n

ahajournals.org/doi/pdf/10.116…
@circulation The job of the lung is to transfer oxygen into the blood so that those oxygen rich red blood cells can deliver oxygen to the rest of your body.

If there is little or no oxygen in a part of your lung, would you want blood flowing to that part of the lung to pick up oxygen?

2/n
@circulation You would NOT want blood flowing to parts of the lung that have little or no oxygen.

Your body prevents this by using "Hypoxic Pulmonary Vasoconstriction (HPV); Hypoxic means no oxygen Pulmonary Vasoconstriction means you make arteries smaller which limits blood flow to a region
Read 16 tweets

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