Do we know that there is 13 scientific evidence already that confer a direct association between #VitaminD deficiency & #COVID19 disease severity-mortality? Yet, no standard guidelines available at the national or international level for common people. THREAD must read and share.
1. Latest trial from Spain with 76 COVID 19 patients found that calcifediol (active form of Vit-D) reduced ICU admission & mortality in 50 patients treated w/calcifediol. only 1 among these 50 needed ICU admission in comparison to 13/26 w/out intervention.
sciencedirect.com/science/articl…
2. A cohort study reported that only 17.6% of patients required oxygen who received Vit-D, magnesium & B12 combination in comparison with 61.5% who didn't receive this combination.
medrxiv.org/content/10.110…
3. A study from Iran found significant alterations in vitamin D and ACE levels as well as NLR (neutrophil to lymphocyte ratio) in the patients’ group. The contribution of those factors with the prognosis and severity of the disease has been shown.
sciencedirect.com/science/articl…
4. In 70 patients, researchers observed more Vitamin D deficiency among COVID positive patients and concluded worse morbidity outcomes may be seen in older adults with vitamin D deficiency and COVID-19.
pmj.bmj.com/content/early/…
5. A retrospective, observational study with 42 patients revealed that after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥10 had a 5% mortality risk.
assets.researchsquare.com/files/rs-41173…
6. A hospital data of 235 patients from Iran showed Vitamin D sufficiency reduced risk for morbidity and mortality in COVID-19 Patients.
papers.ssrn.com/sol3/papers.cf…
7. A Mexican study with 172 COVID 19 patients demonstrated patients with vitamin D serum levels below 8 ng/mL had a 3.68 higher risk of dying from COVID-19.
medigraphic.com/pdfs/sanmil/sm…
8. A retrospective analysis in hospitalized COVID 19 patients found that patients requiring ITU admission were more frequently vitamin D deficient than those managed on medical wards, despite being significantly younger.
medrxiv.org/content/10.110…
9. A study from Belgium with 186 patients concluded vitamin D deficiency is a prevalent risk factor for severe COVID-19. Vitamin D supplementation might be inexpensive and safe mitigation for the SARS-CoV-2 pandemic.
medrxiv.org/content/10.110…
10. Swiss study with 107 COVID 19 patients found significantly lower 25(OH)D levels in PCR-positive for SARS-CoV-2 compared with negative patients (24.6 ng/mL)
mdpi.com/2072-6643/12/5…
11. Among 4,314 patients from Chicago tested for COVID-19 those with pre-existing Vitamin D deficiency were more likely to test positive for the disease in comparison to those who were having a sufficient level of Vitamin D.
medrxiv.org/content/10.110…
12. A population-based study among 4.6 million members of Clalit Health Services (CHS) in Israel showed a strong association between vitamin D deficiency and Covid-19 occurrence. Vitamin D tests performed between 2010 and 2019.
medrxiv.org/content/10.110…
13. Israeli study in 7807 COVID 19 patients demonstrated an association between the low plasma 25(OH)D level and increased likelihood of COVID‐19 infection and of hospitalization due to the SARS‐CoV‐2 virus
febs.onlinelibrary.wiley.com/doi/full/10.11…

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More from @DrSubhasree

19 Sep
THREAD: Evidence-based knowledge on Raw SPROUTS: Benefits and Risks.

1. What are sprouts?
- Sprouts are seeds that are germinated into young plants by being soaked for several hours. They are usually eaten raw and are available in a wide range of varieties. Highly nutritious. Image
1. Overall NUTRITIONAL Benefits:

A. The sprouting process increases nutrient levels, making sprouts richer in protein, folate, magnesium, phosphorus, manganese, and vitamins C and K. Sprouting increases the level of certain essential amino acids by 30%.
pubmed.ncbi.nlm.nih.gov/28370158/ Image
B. The proteins in sprouts are easier to digest. The sprouting process reduces the amount of antinutrient compounds that decrease your body’s ability to absorb nutrients from the plant by up to 87%.
pubmed.ncbi.nlm.nih.gov/24915317/
experiencelife.com/article/all-ab… Image
Read 12 tweets
18 Sep
The race for #coronavirus vaccines: a graphical guide by @nature. Eight ways in which scientists hope to provide immunity to #SARSCoV2.

This thread is to provide an insight into how 4 different types of vaccines work.

Vaccine Basics: How we learn to develop immunity
SARS-CoV-2 vaccines: a variety of approaches
All vaccines aim to expose the body to an antigen that won’t cause disease but will provoke an immune response that can block or kill the virus if a person becomes infected.
1.Virus Vaccines: At least 7 teams are developing vaccines using the virus itself, in a weakened/inactivated form. Measles and polio vaccines are made this way. These require extensive safety testing. Sinovac Biotech in Beijing is one of these.
Read 7 tweets
7 Sep
As we already know that #COVID19 is majorly affecting people who are living with #Diabetes Mellitus, high BP, high cholesterol, and obesity, in this thread, the association between diabetes and infections are explained.

1. How diabetes affects the body (from head to toe).
2. Immunity and Diabetes: Diabetes has been associated with the reduced response of T cells, neutrophil function, and disorders of humoral immunity. Consequently, the disease increases the susceptibility to infections.
pubmed.ncbi.nlm.nih.gov/10575137/
3. What are the major infections associated with diabetes?

There is clinical evidence pointing to the higher prevalence of infectious diseases among individuals with diabetes mellitus.
pubmed.ncbi.nlm.nih.gov/16007521/
Read 5 tweets
6 Sep
IMPORTANT: #COVID19 and #VitaminB: Vitamin B plays a vital role in cell functioning, energy metabolism, activation of innate & adaptive immune responses, reduce cytokine levels, improves respiratory function, and can reduce the length of stay in hospital. ncbi.nlm.nih.gov/pmc/articles/P…
1. Thiamine or B1: As antibodies, & importantly T-cells, are required to eliminate the #SARS_CoV_2 virus, thiamine deficiency can potentially result in inadequate antibody responses, and subsequently more severe. Factsheet attached.
link.springer.com/chapter/10.100…
2. Vitamin B2 (Riboflavin): Riboflavin & UV light has been shown to be effective against the MERS-CoV virus, could also be helpful against SARS-CoV-2. Also decreased the infectious titer of SARS-CoV-2 below the limit of detection in human blood.
journals.plos.org/plosone/articl…
Read 12 tweets
3 Sep
IMPORTANT: New 'Bradykinin' theory in #COVID19 and target-based therapeutic intervention.

According to the latest research, Bradykinin might be responsible for major symptoms in COVID like cough, sneeze, stuffy nose, leaky blood vessels, etc.
1. Using a supercomputer, Dr. Jacobson and the team first discovered very distinct patterns in the data from the patients' bradykinin systems. Unlike cytokine, bradykinins handle infection via inflammation & generate typical symptoms of influenza & cold.
the-scientist.com/news-opinion/i… Systemic-level effects of critically imbalanced RAS and brad
2. Bradykinin inflammatory pathway in COVID-19:

COVID-19 patients' lungs include an abundance of enzymes that trigger the production of bradykinins & unexpectedly few enzymes can break it down. This causes bradykinin storm, allowing for fluid to build up around the lungs. The leaky blood vessels and lung fluid build-up in some COVI
Read 8 tweets
1 Sep
Making a case for #VitaminD during #COVID19: This pandemic is affecting obese, diabetics, hypertensives, malnourished & immune suppressants. In India, 82% deaths due to COVID is related to co-morbidities.

VITAMIN D is related to all these.

1. Immunity: intechopen.com/books/vitamin-…
2. Diabetes: One of the major risk factors to contract the virus, severe disease progression & mortality. Prevalence of diabetes in India is ~12% and growing. Vitamin D definiciency is associated with impaired insulin sensitivity & glucose metabolism, i.e. occurrence of diabetes.
3. Obesity: obesity is most common cause of COVID 19 deaths. The prevalence varies from 11.8-31.3%. Vitamin D deficiency causes obesity and if you are obese, you are more prone to be Vitamin D deficient. This is a 2 way relationship. (1/2)
onlinelibrary.wiley.com/doi/10.1002/dm…
Read 8 tweets

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