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Eric Topol Profile picture
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7 Oct, 4 tweets, 2 min read
On today's message from Trump about his mAb treatment: "The gave me Regeneron" "at my suggestion" "I felt well immediately"
He now claims: "I call it a cure," "I've authorized the EUA" "Everyone will get them free"
All false. All predictable.
The things said were so far off the truth I made a tabular summary
Quotes from the video
More on monoclonals vs #SARSVoV2 and the unclear potential it had in this patient
A few points to add:
1. Trump has reluctantly acquiesced getting FDA emergency authorization (EUA) for the vacccine before Nov 3rd (now "its a few days later).
2. He's turned his attention to pushing thru the EUA on monoclonal antibodies
3. That's using it for political purposes

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More from @EricTopol

Eric Topol Profile picture
9 Oct
My interview with @US_FDA Commissioner @SteveFDA today @Medscape on the #SARSCoV2 vaccines, monoclonal antibodies, and rapid home tests 1/
medscape.com/viewarticle/93…
Recall I had sent an open letter to him August 31 after the convalescent plasma "breakthrough" press conference, w/o any supportive evidence, and the prior EUA on hydroxychloroquine medscape.com/viewarticle/93…
He didn't take either option I suggested. He called me. 2/
We've since spoken several times and now I understand his intentions, what he's been through, the immense pressures that have been placed upon him. For me, the trust in him and the FDA has been restored. 3/ Image
Read 18 tweets
Eric Topol Profile picture
8 Oct
Dr. Conley does it again. He clears Trump for public engagements in 2 days, without evidence that he is not infectious, without viral load data, without providing when/timeline he became infected. Image
Yesterday Dr. Conley ordered & reported a positive IgG antibody test in a patient who received a massive dose of IgG antibodies.
Today, without even committing to simple PCR tests to verify Trump is not shedding virus, he's cleared to meet with large crowds of unmasked people.
BTW CDC Guideline of 10 days (this is 9 days) is a *guideline*. This is a unique individual (in many ways) who received monoclonal antibodies, not expected to achieve mucosal immunity. And the early dexamethasone would suppress T cell response.
Read 4 tweets
Eric Topol Profile picture
8 Oct
We had the distinct privilege of talking with @cmyeaton about the pandemic, for which she has been a leading light. medscape.com/viewarticle/93…
w/ @cuttingforstone @Medscape w/ transcript
@JHSPH_CHS
Here's some of the things we discussed and learned from @cmyeaton
1. What prompted her to become an epidemiologist?
2. Dr. Yeaton and colleagues wrote the essential report in April providing guidance for reopening. @JHSPH_CHS
centerforhealthsecurity.org/our-work/pubs_…
If only the states had adhered to the guidelines, we could have achieved containment of the virus
Read 15 tweets
Eric Topol Profile picture
5 Oct
A rather important letter @ScienceMagazine just published that stresses #SARSCoV2 aerosol transmission (size < 100 μm) and what should be done about it.
By @kprather88 @linseymarr @mmcdiarm @Don_Milton and colleagues science.sciencemag.org/content/early/…
For background, this is the previous, now classic essay on the topic by @kprather88 and colleagues @ScienceMagazine science.sciencemag.org/content/368/64…
One of the most downloaded papers of the pandemic (millions)
That was quick!
Read 4 tweets
Eric Topol Profile picture
4 Oct
Did monoclonal antibodies save the President's life?
We'll never know, but it's possible and the implications are profound.
Let me explain 1/
Trump's risk profile by demographics was high (age, male, obesity) but it markedly increased when he had blood oxygen desaturation, had an abnormal lung CT scan of pneumonia, and was hospitalized
Mortality risk > 32% isaric4c.net/risk/ 2/
Sometime on Friday (<-presumably) he received a monoclonal antibody cocktail (2 different antibodies to override the potential of a virus escape variant)
Diagram from @VirusesImmunity 3/
Read 17 tweets
Eric Topol Profile picture
4 Oct
The lies are coming out now
1. There was a rapid decline in oxygen saturation Friday
2. He received supplemental oxygen
3. He had a high spike in fever
4 .Lung CT abnormal
5. Transferred expediently d/t change in condition
time.com/5895970/trump-…
Now dexamethasone has been added to the kitchen sink of drug interventions. For his "brief" need for oxygen? (compared with no oxygen). Patients in the pivotal trial showed no benefit, and potential harm, if oxygen was not received.
Examples of the extreme deception
—How low did the oxygen saturation go? In the low 90's?
—It did not go into the low 80's

—What did the lung scan show?
—The expected findings
Read 5 tweets

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