Sara Dong Profile picture
22 Oct, 10 tweets, 9 min read
#IDWeek2020
Now to watch Mano a Mano, always a great session!! @PIDSociety
#IDWeek2020 #PedsID
Session: Mano a Mano
Should we tx + tracheal cultures?

Con: @asicksamuels
3 Reasons not to treat:
1. Positive cxs do not equal infection
2. Trach cxs are unreliable
3. Treated positive trach cxs do not equal improved outcomes
+
Risk patient harm from over-tx
#IDWeek2020 #PedsID
Session: Mano a Mano
Should we tx + tracheal cultures?

Pro:
VAT assoc'd w/⬆️duration of mech vent, ICU LOS, mortality
Tx of VAT can prevent progression to VAP and perhaps mortality
Treating VAT w/impaired oxygenation is really tx'ing VAP, which is warranted
#IDWeek2020 #PedsID
Session: Mano a Mano
Should we treat positive tracheal cultures?

Classic #PedsID consult question!

Final consensus: Image
#IDWeek2020 #PedsID
Session: Mano a mano
Vanc for invasive staph

PRO:
Vanc still good empiric choice
We have hx, experience to ask about risk factors for nephrotox
Monitoring might not be needed if only using 48h
Can use AUC/MIC:⬇️toxicity, don't have to use $$ Bayesian software ImageImage
#IDWeek2020 #PedsID
Session: Mano a mano
Vanc for invasive staph

CON:
Abandon vanc
We do not really know how to dose or monitor vanc for efficacy against MRSA in sick kids
There is harm: toxicity, delays in "therapeutic" levels
Less toxic alternatives ImageImageImage
#IDWeek2020 #PedsID
Session: Mano a mano
Vanc for invasive staph

Final consensus: Image
#IDWeek2020 #PedsID #TxID
Session: Mano a mano
Do you tx child with parent who refuses to vaccinate?

Excited to see @tanviboston @BCHPedsID !

Defer/Con:

VPI in kids after SOT: pubmed.ncbi.nlm.nih.gov/30640369/

No natl policy requiring completion of vacc, so left to casebycase/indl ctrs Image
#IDWeek2020 #PedsID #TxID
Session: Mano a mano
Do you tx child with parent who refuses to vaccinate?

List/Pro:
If not listed➡️death
At some pt, does risk of dialysis/underlying dz outweigh risk of VPI?
Is it fair to deny child waiting time due to parent decision Image
#IDWeek2020 #PedsID #TxID
Session: Mano a mano
Do you tx child with parent who refuses to vaccinate?

No rebuttals - a very difficult topic with excellent discussion. Needs careful education and medical/ethical considerations + joint decision making with parents/patients

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More from @swinndong

24 Oct
#IDWeek2020
Session: Cutting edge adult&ped #TxID

First up, @BrianFisher95 on adenovirus and EBV Image
#IDWeek2020
Session: Cutting edge adult&ped #TxID
@BrianFisher95

Adenovirus reactivation is more common in pediatric HCT pts, so age is significant risk factor

Chart with reactivation rates, mostly ped data 👇 Progression to sx dz in peds is not uncommon ImageImageImage
#IDWeek2020
Session: Cutting edge adult&ped #TxID
@BrianFisher95

So what to do when adenovirus is positive ImageImage
Read 34 tweets
24 Oct
#IDWeek2020
Session: Viral infections in Ped SOT
Starting with Sharon Chen Image
#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

1) Thinking about CMV through a new lens ImageImage
#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

2) Grateful for the discussion on EBV+PTLD one of my interests, we have so so much to learn about this relationship in both adults and pediatrics Image
Read 19 tweets
24 Oct
#IDWeek2020
So excited for challenging cases in #TxID !

Pearlie Chong @PergamIC @ShohamTxID @nikkitheomd @IDdoc4kids Kate Mullane
#IDWeek2020
Session: Challenging Cases in #TxID
56 yo post-auto HSCT with fever, wt loss, scleral icterus. Labs with low WBC, anemia, elevated LFTs. Not neutropenic.

Check out the smear! ImageImage
#IDWeek2020
Session: Challenging Cases in #TxID

Dx: Babesiosis - Familiar to us here in MA, but this case was from WA!

Very tough to manage in immunosuppressed pts, require prolonged courses ImageImageImage
Read 19 tweets
23 Oct
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

Thinking about how PWID can be treated with OPAT at home ImageImageImage
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

OPAT completion in PWID was comparable to those who do not inject drugs

Retrospective studies of carefully selected pts -- but that is also true of who you select in real life Image
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

No difference in keeping of appts, infusion location, infection type

Longer period of abstinence may indicate better OPAT outcome Image
Read 13 tweets
23 Oct
#IDWeek2020
Session: Hospital infection control and environmental sustainability: challenges and opportunities!
@preets579

Infection prevention reality vs environmental sustainability - can we achieve a balance? Image
#IDWeek2020
Session: Hospital IC: challenges and opportunities!
@preets579

Learned about life cycle assessments today!

Reusable gowns had 28% reduction in energy consumption, but data is variable - as in those that did note advantage to reusable laryngoscopes vs single use ImageImage
#IDWeek2020
Session: Hospital IC: challenges and opportunities!
@preets579

Manufacturers are incentivized to make single use products based on recommendations -- so what is the opportunity here? Does the frame of emerging pathogens shape our ethos towards single use devices?
Read 6 tweets
23 Oct
#IDWeek2020
Session: Challenging Cases #PedsID

Some case thinking in a "COVID-free zone" Image
#IDWeek2020
Session: Challenging Cases #PedsID

Cerebral toxoplasmosis in alloHCT pt

CSF cytology actually noted tachyzoites - great image! ImageImage
#IDWeek2020
Session: Challenging Cases #PedsID

Fusobacterium necrophorum causing liver and renal abscess

Anonymous vampire pic appreciated 🧛 ImageImageImage
Read 7 tweets

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