#IDWeek2020
Session: Challenging Cases #PedsID

Some case thinking in a "COVID-free zone"
#IDWeek2020
Session: Challenging Cases #PedsID

Cerebral toxoplasmosis in alloHCT pt

CSF cytology actually noted tachyzoites - great image!
#IDWeek2020
Session: Challenging Cases #PedsID

Fusobacterium necrophorum causing liver and renal abscess

Anonymous vampire pic appreciated 🧛
#IDWeek2020
Session: Challenging Cases #PedsID

9 mo with SCID with disseminated BCGitis and mycobacterial pseudotumor (wow to the image!)

Usually local but likely hematog spread in this case as bcxs positive
#IDWeek2020
Session: Challenging Cases #PedsID

Another session, another case of tick paralysis!

Toxin-mediated process, although paralysis doesn't occur until prolonged bloodmeal (4-5 days)

Check out the scalp/hair and behind the ear!!
#IDWeek2020
Session: Challenging Cases #PedsID

2yo with ALL, 3wks of neuro decline, ultimately dx'd via mNGS with Astrovirus VA-1/HMO-C

Can cause acute/progressive encephalitis in ICH
Does not have to be associated with GI illness

Pt survived despite ⬆️reported mort!
#IDWeek2020
Session: Challenging Cases #PedsID

16F previously healthy p/w fever, AMS - ultimately found to have MSSA endocarditis with embolic phenomena

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More from @swinndong

24 Oct
#IDWeek2020
Session: Cutting edge adult&ped #TxID

First up, @BrianFisher95 on adenovirus and EBV Image
#IDWeek2020
Session: Cutting edge adult&ped #TxID
@BrianFisher95

Adenovirus reactivation is more common in pediatric HCT pts, so age is significant risk factor

Chart with reactivation rates, mostly ped data 👇 Progression to sx dz in peds is not uncommon ImageImageImage
#IDWeek2020
Session: Cutting edge adult&ped #TxID
@BrianFisher95

So what to do when adenovirus is positive ImageImage
Read 34 tweets
24 Oct
#IDWeek2020
Session: Viral infections in Ped SOT
Starting with Sharon Chen Image
#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

1) Thinking about CMV through a new lens ImageImage
#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

2) Grateful for the discussion on EBV+PTLD one of my interests, we have so so much to learn about this relationship in both adults and pediatrics Image
Read 19 tweets
24 Oct
#IDWeek2020
So excited for challenging cases in #TxID !

Pearlie Chong @PergamIC @ShohamTxID @nikkitheomd @IDdoc4kids Kate Mullane
#IDWeek2020
Session: Challenging Cases in #TxID
56 yo post-auto HSCT with fever, wt loss, scleral icterus. Labs with low WBC, anemia, elevated LFTs. Not neutropenic.

Check out the smear! ImageImage
#IDWeek2020
Session: Challenging Cases in #TxID

Dx: Babesiosis - Familiar to us here in MA, but this case was from WA!

Very tough to manage in immunosuppressed pts, require prolonged courses ImageImageImage
Read 19 tweets
23 Oct
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

Thinking about how PWID can be treated with OPAT at home
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

OPAT completion in PWID was comparable to those who do not inject drugs

Retrospective studies of carefully selected pts -- but that is also true of who you select in real life
#IDWeek2020
Session: OPAT in PWID
@mmPharmD

No difference in keeping of appts, infusion location, infection type

Longer period of abstinence may indicate better OPAT outcome
Read 13 tweets
23 Oct
#IDWeek2020
Session: Hospital infection control and environmental sustainability: challenges and opportunities!
@preets579

Infection prevention reality vs environmental sustainability - can we achieve a balance?
#IDWeek2020
Session: Hospital IC: challenges and opportunities!
@preets579

Learned about life cycle assessments today!

Reusable gowns had 28% reduction in energy consumption, but data is variable - as in those that did note advantage to reusable laryngoscopes vs single use
#IDWeek2020
Session: Hospital IC: challenges and opportunities!
@preets579

Manufacturers are incentivized to make single use products based on recommendations -- so what is the opportunity here? Does the frame of emerging pathogens shape our ethos towards single use devices?
Read 6 tweets
22 Oct
#IDWeek2020
Now to watch Mano a Mano, always a great session!! @PIDSociety
#IDWeek2020 #PedsID
Session: Mano a Mano
Should we tx + tracheal cultures?

Con: @asicksamuels
3 Reasons not to treat:
1. Positive cxs do not equal infection
2. Trach cxs are unreliable
3. Treated positive trach cxs do not equal improved outcomes
+
Risk patient harm from over-tx
#IDWeek2020 #PedsID
Session: Mano a Mano
Should we tx + tracheal cultures?

Pro:
VAT assoc'd w/⬆️duration of mech vent, ICU LOS, mortality
Tx of VAT can prevent progression to VAP and perhaps mortality
Treating VAT w/impaired oxygenation is really tx'ing VAP, which is warranted
Read 10 tweets

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