Thread by @swinndong

#IDWeek2020
Session: Viral infections in Ped SOT
Starting with Sharon Chen

#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

1) Thinking about CMV through a new lens

#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

2) Grateful for the discussion on EBV+PTLD one of my interests, we have so so much to learn about this relationship in both adults and pediatrics

#IDWeek2020
Session: Viral infections in Ped SOT
Sharon Chen

It is not as easy as monitoring EBV VL
DNAemia doesn't always translate to more PTLD, there can be a disconnect

We have a lot of space to learn in this area, so hopefully a good place for fellows to jump in!

#IDWeek2020
Session: Viral infections in Ped SOT

3) Thinking about adenovirus and pediatric SOT

Children <2yo may be the ones who need more help, and can we focus picture on those with high risk

#IDWeek2020
Session: Viral infections in Ped SOT
@posfay

Live vaccines after SOT

Can check out these surveys:
pubmed.ncbi.nlm.nih.gov/32964637/
onlinelibrary.wiley.com/doi/abs/10.111…

#IDWeek2020
Session: Viral infections in Ped SOT
@posfay

Tripod/questions to consider for LAV after SOT

#IDWeek2020
Session: Viral infections in Ped SOT
@posfay

#IDWeek2020
Session: Viral infections in Ped SOT
@posfay

Reference:
onlinelibrary.wiley.com/doi/abs/10.111…

#IDWeek2020
Session: Viral infections in Ped SOT

Thanks @posfay !

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

Starting with HCV

I learned about data on glecaprevir/pibrentasvir (mavyret) in pediatrics

pubmed.ncbi.nlm.nih.gov/31254392/

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

Saying yes to HCV+ donors

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

HBV

Key: exists as a closed circular chromosome within nucleus ➡️ because of this, there is no "cure" after HBV infection, only various level of immune control

Because of CCC, liver is forever a reservoir for HBV

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

HBV

Key resource from @AST_IDCOP : onlinelibrary.wiley.com/doi/full/10.11…

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

HBV + Transplant scenarios

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

HBV Vaccination Pre-transplant

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

How about non-responders?

Follow titers post-tx: if HBV titers fall below 10 IU/ml, revaccinate

#IDWeek2020
Session: Viral infections in Ped SOT
Ravi Jhaveri

Recent changes when thinking about increased risk

Saving link! optn.transplant.hrsa.gov/governance/pub…