Covid (@UCSF) Chronicles, Day 224

1/ When I walk or drive around SF, I see evidence of why Covid cases & deaths are the lowest of any big city in the U.S. Masking is near universal, Ubers & Lyfts have their windows wide open, & there are pop-up outdoor eating spaces everywhere.
2/ So, as we enter a 3rd wave that's blanketing the nation, I’ll focus today on San Francisco – specifically the question of whether SF can continue its remarkable Covid success in the face of a national surge, one far more geographically distributed than the prior two waves.
3/ I’ll go out on a limb and say yes… and hope that I’m not proven wrong.

History is with us: when all of California began to surge in June, SF was able to turn it around – whereas much of the rest of CA didn’t and was hit far harder. Ditto for the southern states.
4/ Before doing a deep dive into the current situation in SF, first a brief overview of the U.S. picture. Bottom line: we’re seeing big surges nearly everywhere. This is different from March-April, which was mostly Northeast; & June-July, which was mostly the South, plus SoCal.
5/ Yes, the upper Midwest is getting hit the hardest (which may be electorally meaningful, in that many of these states also happen to be swing states). But all regions of the country are heading in the wrong direction.
6/ And CA is starting to get hot as well – graphs on L (@sfchronicle) show small but meaningful uptick in cases in past wk. On R (from Rt.live): CA’s reproduction # , previously <1, now up to 1.09. While not as bad as the Midwest, it’s concerning & may get worse.
7/ Now, let’s zoom in on Northern CA. The nine counties that make up the Bay Area are seeing a smaller but potentially meaningful bump up in cases. The death curve is a bit bouncy, but one gets the sense of a small uptick here too.
8/ Finally, let’s home in on San Francisco. As this piece from yesterday's @latimes describes, SF remains a bright light among the largest U.S. cities tinyurl.com/y5vc75pj. I’ll start the SF update with the view from @UCSFHospitals, and then broaden the lens to all of SF.
9/ @UCSFHospitals, we’re up to 15 pts, only 4 in the ICU & one on a ventilator (Fig). This is a meaningful bump since last week, when we went as low as 9 hospitalized pts. Worrisome. On the other hand, our test positivity rate has remained quite low: 2.4% overall, comprised of…
10/ … 3.1% for patients w/ symptoms consistent w/ Covid, and 0.45% in patients w/o symptoms (such as pts admitted for procedures). You may recall that I use the latter % to estimate the chances that someone near me in the supermarket has Covid. At 1-in-220, it feels pretty safe.
11/ So the uptick in hospital pts @UCSF is a bit concerning, but the low test + rate is reassuring. How about SF overall? That too is comforting, especially considering what we’re seeing elsewhere. Cases averaging 32/day, stable for past wk & well below our July-Aug peak of 130.
12/ In all of SF, we’ve had 140 Covid deaths so far. As I’ve said, this is simply astounding, representing 16 deaths/100,000 people. If the entire U.S. had that per capita death rate, we’d have had 52K deaths, rather than 226K. In other words, 174,000 people would be alive today.
13/ Like @UCSF, SF’s test positivity rate remains blessedly low: 0.84% (Fig L). This compares to CA's rate of 3.2% (still pretty stable), & national average (Fig R), which has ticked up to 6.3% from the mid-4’s a few weeks ago. Some Midwestern states are in the 20-30% range.
14/ Hospital # 's in SF also reassuring: 29 total, up just a bit from low 20s 2 wks ago. So rather than the rise in UCSF hospitalizations indicating a SF trend, it looks like UCSF is getting a larger share; now ~50% of SF’s hospital Covid pts (vs ~25% in summer). Reason: unclear.
15/ Taken as a whole, it looks like CA is doing fairly well compared to the hardest-hit states, though we’re seeing the early signals of a surge. And San Francisco is doing better than that – avoiding this surge, at least so far. It’s far too early to declare victory. In fact…
16/ … it seems unlikely that – with the amount of intra- & interstate travel – that SF can totally dodge the impact of a national wave, even if the Mayor and public health leaders continue to do the right things, and the people remain vigilant and follow the public health rules.
17/ The latter point is key: more and more real-world data is demonstrating the tight connection between mask-wearing and preventing Covid. This graph, from @washingtonpost, shows the inverse relationship between mask wearing and cases. It’s just not that complicated: masks work.
18/ I remain confident that SF will continue to “dance” effectively, per the “Hammer and the Dance” metaphor tinyurl.com/yx27etx9. While I’ve heard many explanations (warm-ish weather, relatively little poverty, more tech) and all of them may contain a grain of truth…
19/ … the most compelling explanation is that San Francisco's numbers reflect what happens when you have strong political, public health and corporate leadership, and residents who believe in science and in keeping themselves, and their fellow human beings, safe.
20/ The current surge is proving, again, that there's nothing about the virus that’s changed in 8 months, and – for the 90% of us who haven't been infected – nothing about us or our mucosal membranes that’s changed either. SF continues to prove that the virus can be contained,...
21/ … making the new (or newly articulated, at least) White House policy of surrender and herd immunity all the more immoral.

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More from @Bob_Wachter

27 Oct
Note that as hospitals get overwhelmed – as appears to be happening in many regions – the welcome fall in mortality rates we've seen since March may erode. While some of the mortality improvements can be explained by proven benefits of dexamethasone (+/- remdesivir) and... (1/3)
... changing demographics (younger & healthier patients), much of it was due to improvements in hospital care and less overwhelmed MD and nursing staffs. If hospitals get hammered, as they were in NY in the spring, I'd expect an uptick in these mortality rates, sadly. (2/3)
Today's curves (cases top; deaths bottom) show the huge surge in cases & usual lag in deaths (though deaths starting to rise). Whether these curves ultimately rise in sync will hinge on whether hospitals & ICUs can avoid being overwhelmed. Current situation isn't promising. (3/3)
Read 4 tweets
27 Oct
I've flown a few times based on my perception of low – but non-zero – risk. This new report of a big outbreak on a 7-hour Irish flight tinyurl.com/y4fs2y7f doesn't change the overall risk calculus (still very low, if passengers wear masks) but adds to the evidence that...(1/3)
... Covid risk is not evenly distributed. The average risk of an encounter is actually a combo of many, many low-risk encounters, combined a few high-risk ones (super-spreader events) tinyurl.com/yxmykmu9. The problem is that there's no good way to predict super-... (2/3)
... spreader events, so we're stuck with dealing w/ "average" risk. This paper tinyurl.com/y4ce3mwh, which estimates the risk of catching Covid from a 2-hr flight at ~1-in-5000, is still what I go by. Based on it, I won't fly for fun or to a mtg, but will fly if crucial. (3/3)
Read 4 tweets
24 Oct
Covid (@UCSF) Chronicles, Day 220

1/ Yesterday was @UCSF Medicine Grand Rounds– we covered the 3rd wave (w/ particular focus on situation in Wisconsin) and how to assess and manage risk in Covid. The conference (70 min) is available here: tinyurl.com/y2to6y9y Worth watching.
2/ @ 5:00: First, an update by George Rutherford on the current surge. The U.S. is now at >60K cases/d. This map, from @nytimes, shows that while biggest surge is in the Midwest, unlike surges 1 and 2 this is really a national surge, with only a few exceptions (one of them CA).
3/ @ 7:30: In California, “no evidence of a 3rd wave…yet.” “I have a feeling that we’re teetering at the precipice, and we need to be absolutely positively clear that we’re doing everything we can to avoid infection.”
Read 23 tweets
22 Oct
Covid (@UCSF) Chronicles, Day 218

1/ Excellent @washingtonpost piece today on Operation Warp Speed, & its (likely) success in moving us from discovery of a new virus to having one or more safe & effective vaccines available in about a year, God willing. tinyurl.com/yybpgcat
2/ Yes, that’s really me quoted below, praising the Trump administration for OSW's success. Bestowing such praise was not easy, since I agree with @KamalaHarris that our overall Covid response may well be the greatest failure of any presidential administration in U.S. history.
3/ But on this one, the administration has gotten it right. While some will quibble w/ choices of which vaccines to bet on, the investments made seem sound – particularly the choice to offer funds to decrease the risk of the companies’ vaccine development process (“de-risking”)…
Read 25 tweets
15 Oct
1/ Covid (@UCSF) Chronicles, Day 211

Now 7 months into the U.S. pandemic and 3 weeks from the election, everybody is exhausted and overwhelmed. Everyone's new question seems to be, “are you optimistic or pessimistic?” The question is simple; the answer, of course, is complex.
2/ Today, I’ll start with the view from San Francisco – consumed by The Trump Show, it’s been a while since I presented our local data. I’ll then describe the scary surges elsewhere and add my take on the optimist/pessimist question.
3/ First, @UCSFHospitals, we have only 10 Covid patients in hospital & just 2 on vents, both lowest since May (Figure). Test positivity rate @UCSF is ~4% in patients w/ symptoms, 0.5% in asymptomatic pts. In Aug, these # 's were 10% / 1.5%, so a vast improvement in every metric.
Read 25 tweets
10 Oct
Just watched the @TuckerCarlson segment with Trump interview by @DrMarcSiegel. Takeaway: Trump looks good, his voice is strong, no visible shortness of breath, he's finishing sentences without stopping for air. Mental status and judgment seem unchanged from his usual. (1/9)
Siegel actually did a decent interview – asking questions testing recall, along with others that got at judgment and insight (latter included asking about lessons learned from this experience). I'm not a Trump fan but it's hard to make 25th Amendment case from what we saw. (2/9)
And, while Trump is still not completely out of the woods – there's still a small (<5%) chance of a significant setback – with a patient this stable 8 days into the illness, his most likely course is a relatively uneventful recovery. (3/9)
Read 9 tweets

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