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Dr Zoë Hyde

@DrZoeHyde

27 Oct

(1/7) Report by Ministry of Health, Israel, showing children more likely to be infected than adults, are mostly asymptomatic, can be superspreaders, that school clusters spread into the community, and that school reopening accelerated the epidemic there.
gov.il/BlobFolder/rep…

(2/7) As shown in the figure below, children were more likely to test positive than adults (8% vs. 6% of all PCR tests conducted in Israel).

Children were also more likely to test positive for #SARSCoV2 antibodies than adults (7% vs. 2 - 5%).

(3/7) Most children with #COVID19 were asymptomatic (51-70%).

As shown in the figure below, children of pre-school & primary school age were more likely to be asymptomatic than older children.

The top (pink) bar indicates the proportion who were asymptomatic in each age group.

Read 8 tweets

Dr Zoë Hyde

@DrZoeHyde

25 Oct

(1/5) Study showing that school closures were associated with a marked reduction in the common cold in adults in the UK.

When schools reopened, rhinovirus detections surged. Physical distancing measures in schools are inadequate to prevent transmission.
thelancet.com/journals/lanre…

(2/5) In this study, patients admitted to hospital between March and September 2020 in Southampton were screened for rhinovirus.

The results were compared against data for 2019.

There was a marked decrease in rhinovirus in 2020, which was associated with school closures.

(3/5) When schools reopened, rhinovirus infections in adults increased, and became comparable to the previous year.

This suggests children are a major driver of the common cold, and that #COVID19 precautions in schools are inadequate to prevent transmission of rhinovirus.

Read 5 tweets

Dr Zoë Hyde

@DrZoeHyde

20 Oct

(1/6) A new pre-print study (interpret carefully) describes *in vitro* evidence of antibody dependent enhancement (ADE) after natural infection with #SARSCoV2 in some people. ADE is when antibodies make a second infection worse.
scmp.com/news/china/sci…

(2/6) If ADE occurs, it is most likely to happen late after recovery when levels of neutralising antibodies have waned.

Here’s the actual study:
medrxiv.org/content/10.110…

(3/6) This review describes what ADE is, how it can occur, and what we know about ADE and other coronaviruses so far.

There is no evidence of ADE occurring with any #COVID19 vaccine under development yet.
stm.sciencemag.org/content/early/…

Read 6 tweets

Dr Zoë Hyde

@DrZoeHyde

14 Oct

This article is damning. I strongly recommend reading it to the end.

“The Swedish way has yielded little but death and misery. And, this situation has not been honestly portrayed to the Swedish people or to the rest of the world.”
time.com/5899432/sweden…

Sweden:

“Only 13% of the elderly residents who died with COVID-19 during the spring received hospital care”

Sweden:

“Policymakers essentially decided to use children and schools as participants in an experiment to see if herd immunity to a deadly disease could be reached”

Read 6 tweets

Dr Zoë Hyde

@DrZoeHyde

14 Oct

(1/8) Contact tracing study from Brunei. Household contacts of symptomatic cases were more likely to be infected than those of asymptomatic cases (14.4% vs. 4.4%). Children and adults were similarly likely to be infected (3.4% children vs. 2.8% adults).
wwwnc.cdc.gov/eid/article/26…

(2/8) This study describes the contract tracing which occurred after 19 people who attended a religious gathering in Malaysia (in which a superspreading event occurred) returned to Brunei.

51 cases were identified via contact tracing (plus 1 further case identified separately).

(3/8) A total of 1,755 contacts were traced, of which 381 were persons aged <18 years, and 1,366 were adults. Age was not recorded for 8 contacts.

Read 8 tweets

Dr Zoë Hyde

@DrZoeHyde

13 Oct

(1/4) Study of a #COVID19 cluster at a family gathering, in which a 13-year old girl was the index case. Despite being only mildly symptomatic, she likely transmitted the virus to 11 of 19 family members (58%). One person was hospitalised, but recovered.
cdc.gov/mmwr/volumes/6…

(2/4) The index case had been exposed to a large #COVID19 outbreak away from home. After returning home, she was tested with a rapid antigen test (four days after exposure) which was negative. She was asymptomatic at the time of the test, and developed symptoms two days later.

(3/4) Rapid antigen tests are generally less sensitive than a PCR test, meaning that not all infections may be detected.

Anyone who is exposed to a person with #COVID19 should self-isolate for 14 days, even if their test result is negative. It may be a false negative.

Read 4 tweets

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