1/ The first rule of Lockdown Club is: You do not talk about deaths per million. The second rule of Lockdown Club is: You do not talk about deaths per million.
2/ Third rule of Lockdown Club: someone yells Sweden or herd immunity, you point out the other Nordics. Fourth rule: only two metrics to a discussion, cases and cases.
3/ Fifth rule: one lockdown per season, fellas. Sixth rule: no deaths, no herd. Seventh rule: lockdowns will go on as long as they have to.
4/ And the eighth and final rule: if this is your first lockdown at Lockdown Club, you have to lockdown hard.
Controversial opinion: those that say its not possible to shield the vulnerable, also won't be able to prove if there is a difference (or lack of it) between the trajectory of the virus at Madrid and Stockholm. Who do you think has let it rip?
1/ There were many "Eureka" moments while working on our paper, but probably the most important of all happened pretty early. Non-linear models are highly sensitive to:
2/ We decided early on to eliminate as many parameters as possible. Location parameters are simple to fix, they are location parameters. Viral parameters also, you can go and say R0=3.3 and you made a choice. How many parameters are left if you do that?
2/ We extended the SEIRS model to support stratified isolation levels for healthy <60 and vulnerable individuals.
3/ We forced the model to predict daily deaths curves and the reported age serology ratio for key metropolitan areas in Europe. The immunity level estimations obtained were: Madrid 43%; Catalonia 24%; Brussels 73%; and Stockholm 65%.
0/n Thank all of you who participated in 'The demon game'. I am taking a screenshot because when knowing the whys it loses all value (there is no more asymmetry of information). These 182 responses are 'The sample'.
1/n You may have already known about this thought experiment you just run on, mainly because there are many different variants of it in the literature. This is the one that I have seen lately:
2/n This example is good because the results are clear-cut to show 2 typical sources of error. Poor experimental setups are the bain of our existence and there are myriad ways they can go wrong.
[1/n] Preparing everything to respond to the question: "Under our isolation epidemic model. Is it possible to correct government policy mismanagement starting at the end of July in 90 days for Madrid, Catalunya and a few other cities?" What do you think? Answers in an hour or so.
[2/n] For those that are new to this thread, you can prepare and hone your skills in modeling with the Harmless Virus Game:
The arrival of a vaccine in the context of COVID can be modeled using game theory as a gamble over the expectation of the final death toll. Most countries will have negative payoff after August 2020. Change my mind. cc @LDjaparidze
Let's make it more interesting... Do you agree?
Context is king. For a gamble to exist we need to define clearly the parameters to observe the likely expected result. Let's start with vaccine efficacy (VE). What do you think is the range most manufacturers are looking for?