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Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
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15 Nov, 8 tweets, 2 min read
Well, I would like to complain about "STATINS".

If you told me you were prescribing me a "STATIN", I would refuse to take it.
Atorvastatin
Simvastatin
Rosuvastatin
Pravastatin
etc.

they are

VASTATINs, not STATINs.
Would you take this statin?
Would you take it?
Glad you wouldn't.

It is SOMATOstatin.

"Endocrine cyanide" to its friends.
No thanks.
Happily today's Late Breaking Trial, SAMSON, studied a VAstatin - atorvastatin - against placebo and no-tablet, to measure the magnitude of side effects.

Results are to be presented by James Howard, who is currently tight-lipped on the subject.
What is the probability that the result will be statistically significant?

Answer is given here:

tweetorials.inspirion.org/h2/6ba588b8da0…

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More from @ProfDFrancis

Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
15 Nov
Elisabeth Bik is a VERY hard woman. I thought she was outing these for "A" and "C" not being differently treated rats, different _slides_, but actually the same slide flipped upside down.

I thought B was actually different.

But then...
.... I saw this too
Remember, do not mock basic science papers for having this level of fakery.
Read 7 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
1 Nov
Not these guys again?!
Are these the outfit whose big-deal Covid model was "Oh, it goes up, then it comes down, so let's just say it is a Normal Distribution!"

If so, I am not surprised at anything they do!

It would be like asking why a puppy is chasing its tail.

Just watch, and enjoy the fun!
As for how effective masks are, I guess they just make up some sort of reduction factor, and model what that does to the spread.

Not terribly exciting. That factor is very uncertain, and it doesn't take a genius to realise that a really small reduction will not contribute much.
Read 6 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
1 Nov
Josh isn't the first person to think of this, merely the last.
Why don't we have such studies?
Who does studies like that? RCTs?
Read 60 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
1 Nov
Both John Mandrola and Vinay Prasad are angry about this study in JAMA. Image
Source: jamanetwork.com/journals/jama/… Image
I thought I might join in and give the study a bashing. Image
Read 35 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
31 Oct
Great question from Pranev Sharma
Personally I have led a charmed life and never been bullied at work.

But as a TPD this is something I am determined to uncover and eradicate.

When I was a junior doctor, we always assumed that if anyone complained about anything "the old bastards will shaft you forever".
But now we once-registrars have become consultants, we realise we are the same people and

(a) Old gits don't actually shaft anyone - they can't be bothered and indeed have no levers for it: nobody cares what some old git says about someone, when making appointments.
Read 8 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
30 Oct
Hidden camera reveals Donald Trump's interaction with Billy Bush.

The really shocking thing wasn't that the Great Leader is a sickening thug, but how a human being can think this behaviour is "benign".

Well done to 2 people for being patient enough to explain it to him, slowly. Image
We need more people like Lena M and Jay Deaz.

Not minimizing or accepting vile behaviour, now has a name, although it is embarrassing that it needs one in a civilized society.

"Active Bystander"

For people who feebly claim that they don't know what to do, there are 4 hints:
Read 9 tweets

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