If these ppl were screening, this would be 888 INFECTIOUS ppl who'd KNOW they’re contagious–and be empowered to act IMMEDIATELY Instead
In USA today, these 888 INFECTIOUS ppl would simply NOT be tested OR find out ~3-7 days later -> often AFTER contagiousness clears!
2/
In this study there was a specificity of 99.5%!
In other words, out of 1000 tests, 5 people would be called falsely positive
This is OK–simply test again- w another rapid confirmatory test that should come with the first test. Those 5 would NOT be likely to be pos on both
3/
POPULATION SCREENING with frequent rapid tests (at home) will allow people to go about days more safely. Do everything else the same. But IF +ve, isolate.
If they can't isolate - for any number of reasons - they'd at least KNOW that they are +ve and can try to limit spread.
4/
For many ppl who WILL have to go to work either way and are reluctant to test for fear of no income... these tests will empower them.
If choice is (i) work and NOT know or (ii) work and KNOW infectious... I choose (ii) any day!!
Small changes even at work can limit spread
5/
RIght now, our status quo is simply no testing, making testing so difficult that most don't get tested till late, or delays causing test results to come back late.
Essentially, no one gets notified in the USA today w results IN TIME to really act to limit spread.
6/
Lets get inexpensive rapid tests BUILT and distributed by the govnt (or w govnt help) to people's homes, works (if appropriate), schools,etc
An infectious case caught is potentially 10's-1000's of cases prevented
Ppl worry transmission could occur at Ct > 30 and thus missed by Ag test
Transmissibility is NOT BINARY
Possible at 34? Yes
Likely? No.
This graph helps place Cts in context!
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(If do not see the full graph above - please click on it)
Easy to forget Ct values are LOG scale
They place as much emphasis on an increase of 1000 viral particles as they do an increase of 1,000,000,000!!
2/
But when we change from a Ct scale to a scale that shows the number of viruses withouth "zooming in" on the low end, we see just how stark a different 20-25 is versus 30-35.
3/
The vaccine is not necessarily a more trusted source of immunity. Both an infection AND a vaccine are likely to induce good immune responses. All of the information we have suggests that immunity to infection for this virus is... well... as expected
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@DrEricDing@VirusesImmunity@PeterHotez However, to the questioners point, we are hoping the vaccines will induce potent and long lasting immunity. The vaccines are designed specifically to direct our immune response to look in the right spot - vs searching all over the virus...
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@DrEricDing@VirusesImmunity@PeterHotez The leading vaccines are all designed to induce, primarily, an antibody response that specifically blocks virus entry. To do this, they display a piece of the spike protein - the key to unlock entry into the cell.
3/
Right... lets keep focusing on PCR lab based medical testing for a public health war
A public health test with a:
-24 hour delay is just OK
-48 hour delay really losing its use
-72 hour delay almost irrelevant for transmission
-96 hour delay - waste
68,671 cases
Pop: 885,000
HIGH test +ve %; i.e. not nearly enough testing
I'd be surprised if catching >1 in 5 cases
If so, does 68,671 => 343,000 cases?
And if so... 39% infected...is SD nearing Herd Immunity?
Should serosurvey much of SD to understand if so.
Note: It's tough to know what the true detection rate is. Is it 1 in 2, 1 in 5, 1 in 8 detected?
We don't know for sure.
Either way... SD has a LOT of it's pop infected.
Since it's one of highest per capita states, will be imprtnt to monitor this state
And no - I am NOT suggesting herd immunity as an option. I'm simply stating the numbers up there and suggesting that we monitor to better understand what has and what will happen.