BREAKING—FDA has granted emergency use authorization for @Regeneron’s monoclonal antibody cocktail REGEN-COV2 (Casirivimab and imdevimab), the same drug given to Trump when he was infected with #COVID19. Only for mild/moderate cases—not hospitalized. 🧵 fda.gov/news-events/pr…
2) There are a lot of rules and FDA stipulations for REGEN-COV2 cocktail use though— cannot be used if patient on oxygen (Trump was) or hospitalized. Children must be 12 or old and weigh 40 kg or more.

regeneron.com/sites/default/…
3) And it’s only for those mild/moderate with “high risk of progressing to severe #COVID19”—and thus need to be defined carefully what constitutes high risk of progressing:
4) unclear price yet. But monoclonal antibodies are expensive and slow to produce because they require biological reactor chambers (rather than pure chemistry combinations of chemicals).
5) that said, “Regeneron now expects to have REGEN-COV2 treatment doses ready for approximately 80,000 patients by the end of November, approximately 200,000 patients by the first week of Jan, and ~ 300,000 patients in total by the end of Jan 2021.” prnewswire.com/news-releases/…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Eric Feigl-Ding

Eric Feigl-Ding Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @DrEricDing

23 Nov
BREAKING—Oxford/Astrazeneca vaccine is 70% effective overall. But one of its dosing regimens of low-then-high yields 90% effectiveness.

Oxford #COVID19 vaccine cheaper than the Pfizer & Moderna vaccines, and does *not* does not require freezing transport.
bbc.com/news/health-55…
2) When volunteers were given two "high" doses the protection was 62%, but this rose to 90% when people were given a "low" dose followed by a high one. Not clear why yet.

The 90% effectiveness data was "intriguing" and would mean "we would have a lot more doses to distribute."
3) There were also lower levels of asymptomatic infection in the low followed by high dose group which "means we might be able to halt the virus in its tracks," Prof Pollard said.

In the UK there are 4 million doses ready to go, with another 96 million to be delivered.
Read 9 tweets
22 Nov
CRITICAL—a negative coronavirus test is **NOT** a ticket to freely socialize without precautions—many are dangerously misguided that it is. It does not negate quarantining, masking & distancing. Here is why 🧵. #COVID19 news.yahoo.com/no-negative-co…
2) There is a virus buildup time — called incubation time—until one usually shows symptoms & viral load high enough to the reliably detected. Usually incubation is 5-6 days, but can be 1-14 days or longer. But if you test too early before viral load builds up, you’ll test neg. Image
3) This does not mean testing is bad—if anything we need more frequent testing. But you can test negative 4 days straight and then positive on day 5. That’s what happened to WH staff K-McEnany and S-Miller—4 negatives before 5th positive. Most people don’t have that luxury. Image
Read 11 tweets
22 Nov
Millions Americans can't celebrate Thanksgiving with their family because the coronavirus gave their relatives "cold dead hands".

Taunting people to "Come and take it" is so irresponsible during pandemic. #COVID19
2) Meanwhile, Cruz can help out at the local morgue if he has time to taunt instead of trying to pass a Coronavirus Relief Bill.
3) Or Cruz can help out at the local El Paso ICU with this nurse in “the pit”
Read 5 tweets
22 Nov
👇IMPORTANT EXPLANATION to vaccine questions. @michaelmina_lab explains it all:

📌“why is a vaccine is a more trusted source of immunity, if already have antibodies & T-Cell response?”

📌“How does vaccine give me more protection than some earlier immunity?” (@dianaberrent asks)
2) In addition to Dr Mina’s above explanation, @VirusesImmunity also explains her rational:
3) Further, noted earlier that the Pfizer & Moderna vaccines both showed better antibody binding & neutralization in vaccinated people in their P1 trials, than convalescent natural infected survivors.

Hence, another reason vaccine better than Scott Atlas’s “herd”. #COVID19
Read 5 tweets
22 Nov
📍Reinfection worry re-emerging—another documented reinfection case - this time of a 21 year old women in South Korea. There are now officially 26 confirmed reinfections and 1 death, and 572 suspected reinfections of #COVID19. Infection is rare but not blue moon rate it seems.
2) The best centralized tracking source for reinfections of #COVID19 worldwide is @BNODesk’s REINFECTION TRACKER page. bnonews.com/index.php/2020…
3) notably, it was two different virus strains. “The spike protein D614G substitution that defines the clade “G” emerged in reinfection, while mutations that characterize the clade “V” (ie, nsp6 L37F and ORF3a G251V) were present at initial infection.” academic.oup.com/cid/advance-ar…
Read 11 tweets
21 Nov
📍NEW—Texas Army National Guard has just arrived in El Paso—they have been assigned the grim work of dealing with the overflow of deceased bodies now piled up in 10 refrigerated mobile morgues. It is hard work—previously county jail inmates. #COVID19
2) Previously it was done by jail inmates for $2/hour for past week.
3) El Paso has tried to hire workers for $27/ hour. But they switched to request for national guard instead and got approval yesterday.
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!