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22 Nov, 11 tweets, 5 min read
📍Reinfection worry re-emerging—another documented reinfection case - this time of a 21 year old women in South Korea. There are now officially 26 confirmed reinfections and 1 death, and 572 suspected reinfections of #COVID19. Infection is rare but not blue moon rate it seems.
2) The best centralized tracking source for reinfections of #COVID19 worldwide is @BNODesk’s REINFECTION TRACKER page. bnonews.com/index.php/2020…
3) notably, it was two different virus strains. “The spike protein D614G substitution that defines the clade “G” emerged in reinfection, while mutations that characterize the clade “V” (ie, nsp6 L37F and ORF3a G251V) were present at initial infection.” academic.oup.com/cid/advance-ar…
4) 🔥 What a CONCLUSION: “Reinfection with a genetically distinct #SARSCoV2 strain may occur in an immunocompetent patient shortly after recovery from mild COVID-19. SARS-CoV-2 infection may not confer immunity against a different SARS-CoV-2 strain.” #COVID19
5) How often does it happen? Well I’ve detailed it in earlier September 2020 thread 🧵 below 👇
6) Notably the WHO and Cornell group documented it and “they calculated risk of reinfection:

📌reinfection risk estimated at 0.01% (95% CI: 0.01-0.02%)

📌incidence rate of reinfection was estimated at 0.36 (95% CI: 0.28-0.47) per 10,000 person-weeks.”
7) How often is that translated?

An incidence rate of reinfection of 0.36 per 10k person-weeks equals:

📌1 reinfection per 30k person weeks

📌1 reinfection per 1000 recovered patients followed for 30 weeks.

📌1 reinfection per 10k recovered patients followed for 3 weeks
8) That said, it is rare. But how rare? Well not impossibly rare. And it’s very hard to officially document and confirm — requires two virus RNA genome sequencing. So let’s take the precautionary principle— don’t assume you can act dangerously even if previously infected!!
9) damnit people— read the conclusion again for me — it says it was in an “immuno-COMPETENT” person, *not* immunocompromised. That’s why I pointed it out with a screenshot. Not a typo!
10) more discussions here. Why is it so seemingly rare? Well finding it is super hard...
11) vaccine bs natural immunity question thread:

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More from @DrEricDing

Eric Feigl-Ding Profile picture
23 Nov
BREAKING—Oxford/Astrazeneca vaccine is 70% effective overall. But one of its dosing regimens of low-then-high yields 90% effectiveness.

Oxford #COVID19 vaccine cheaper than the Pfizer & Moderna vaccines, and does *not* does not require freezing transport.
bbc.com/news/health-55…
2) When volunteers were given two "high" doses the protection was 62%, but this rose to 90% when people were given a "low" dose followed by a high one. Not clear why yet.

The 90% effectiveness data was "intriguing" and would mean "we would have a lot more doses to distribute."
3) There were also lower levels of asymptomatic infection in the low followed by high dose group which "means we might be able to halt the virus in its tracks," Prof Pollard said.

In the UK there are 4 million doses ready to go, with another 96 million to be delivered.
Read 9 tweets
Eric Feigl-Ding Profile picture
22 Nov
CRITICAL—a negative coronavirus test is **NOT** a ticket to freely socialize without precautions—many are dangerously misguided that it is. It does not negate quarantining, masking & distancing. Here is why 🧵. #COVID19 news.yahoo.com/no-negative-co…
2) There is a virus buildup time — called incubation time—until one usually shows symptoms & viral load high enough to the reliably detected. Usually incubation is 5-6 days, but can be 1-14 days or longer. But if you test too early before viral load builds up, you’ll test neg. Image
3) This does not mean testing is bad—if anything we need more frequent testing. But you can test negative 4 days straight and then positive on day 5. That’s what happened to WH staff K-McEnany and S-Miller—4 negatives before 5th positive. Most people don’t have that luxury. Image
Read 11 tweets
Eric Feigl-Ding Profile picture
22 Nov
Millions Americans can't celebrate Thanksgiving with their family because the coronavirus gave their relatives "cold dead hands".

Taunting people to "Come and take it" is so irresponsible during pandemic. #COVID19
2) Meanwhile, Cruz can help out at the local morgue if he has time to taunt instead of trying to pass a Coronavirus Relief Bill.
3) Or Cruz can help out at the local El Paso ICU with this nurse in “the pit”
Read 5 tweets
Eric Feigl-Ding Profile picture
22 Nov
👇IMPORTANT EXPLANATION to vaccine questions. @michaelmina_lab explains it all:

📌“why is a vaccine is a more trusted source of immunity, if already have antibodies & T-Cell response?”

📌“How does vaccine give me more protection than some earlier immunity?” (@dianaberrent asks)
2) In addition to Dr Mina’s above explanation, @VirusesImmunity also explains her rational:
3) Further, noted earlier that the Pfizer & Moderna vaccines both showed better antibody binding & neutralization in vaccinated people in their P1 trials, than convalescent natural infected survivors.

Hence, another reason vaccine better than Scott Atlas’s “herd”. #COVID19
Read 5 tweets
Eric Feigl-Ding Profile picture
22 Nov
BREAKING—FDA has granted emergency use authorization for @Regeneron’s monoclonal antibody cocktail REGEN-COV2 (Casirivimab and imdevimab), the same drug given to Trump when he was infected with #COVID19. Only for mild/moderate cases—not hospitalized. 🧵 fda.gov/news-events/pr…
2) There are a lot of rules and FDA stipulations for REGEN-COV2 cocktail use though— cannot be used if patient on oxygen (Trump was) or hospitalized. Children must be 12 or old and weigh 40 kg or more.

regeneron.com/sites/default/…
3) And it’s only for those mild/moderate with “high risk of progressing to severe #COVID19”—and thus need to be defined carefully what constitutes high risk of progressing:
Read 5 tweets
Eric Feigl-Ding Profile picture
21 Nov
📍NEW—Texas Army National Guard has just arrived in El Paso—they have been assigned the grim work of dealing with the overflow of deceased bodies now piled up in 10 refrigerated mobile morgues. It is hard work—previously county jail inmates. #COVID19
2) Previously it was done by jail inmates for $2/hour for past week.
3) El Paso has tried to hire workers for $27/ hour. But they switched to request for national guard instead and got approval yesterday.
Read 6 tweets

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