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Dr Able Lawrence🦉MD DM Profile picture
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29 Nov, 4 tweets, 3 min read
Reliance Jio Customer Torture Service is the worst customer outreach program in existence.
My big mistake porting my mobile number from BSNL (another Jio success story in turning a great public facility to dust) to Reliance Jio network. @reliancejio @reliancegroup #Jio 1/n
I got an SMS on a Saturday afternoon before an extended weekend informing me that there was small unbilled amount with my previous service provider BSNL & hence Jio is disconnecting my services. Immediately my phone lost signal & network. Not even SMS or OTP possible 2/n Image
Although my credit card and debit card are blocked due to the OTP block, I managed to pay dues to BSNL.
When you follow the link in the SMS to update payment details, it asks you for an OTP (which of course you can't get because SMS is blocked
You need OTP to activate OTP! 3/n Image
I wasted hours trying to contact #JioTortureService Customer Torture Agents who simply tell you off asking you to contact BSNL at best or mostly ignore you and sign off after typing are you online.
After 24 hours of this, one guy says it would be rectified in 72 hours 4/n Image

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More from @abledoc

Dr Able Lawrence🦉MD DM Profile picture
26 Aug
Germinal Centre defects in severe COVID19 patients who died cripples effective antibody response. It probably explains why it takes upto 4-5 weeks (incubation upto 2, then 2-3) for antibodies to form. 10% produce no antibodies at all. #CovidImmunity
sciencemag.org/news/2020/08/c…
Short lived nature of the antibody response after COVID19 infection makes dreams of Herd immunity from natural infections a mirage if ever it was even a thing. OTOH, vaccines "may" produce long lived antibodies, particularly with the RNA vaccines.
sciencemag.org/news/2020/08/s…
Defects in Germinal center formation explains the short duration and/or lack of effective antibody response in COVID19. Most antibodies are derived from non-GC Bcells. TFh differentiation defects underlie the lack of Bcl6+ TFh & Follicular Bcells. Bodes poorly for Herd immunity.
Read 7 tweets
Dr Able Lawrence🦉MD DM Profile picture
14 May
Asians & others with darker skin living in Northern latitudes are prone to Vitamin D Deficiency? Severe COVID19 males had lower vitamin D levels. (Females take more supplements) Vitamin D plays key roles in cardiovascular & immune systems 1/n #VitaminD
blogs.scientificamerican.com/observations/a…
Vitamin D regulates the expression of PLC-γ1 in naive T cells & is key to T cell responsiveness in humans. Poor primary T cell response can affect immune responses to viral infections including influenza & coronaviruses. 2/n @Ms_Aflatoon #VitaminD
nature.com/articles/ni.18…
Vitamin D necessary for IFN-γ–induced antimicrobial peptide cathelicidin expression, autophagy, phagosome-lysosome fusion, and antimicrobial activity crucial to TB & leprosy immunity. Before antibiotics sunlight was the only treatment for tuberculosis 3/n
stm.sciencemag.org/content/3/104/…
Read 10 tweets
Dr Able Lawrence🦉MD DM Profile picture
20 Apr
@nntaleb There are sufficient mechanistic studies to believe there could be a synergy between Zinc and Hydroxychloroquine.
Zinc has activity against multiple virus families including coronavirus.
Hydroxychloroquine is a Zinc chelator and potentiates Zinc effects. Will post references 1/n
@nntaleb Zn2+ Inhibits Coronavirus and Arterivirus RdRP RNA dependent RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture 2/n
journals.plos.org/plospathogens/…
@nntaleb Zinc ionophores inhibit other RNA viruses such as Dengue Virus as well. So this is a generic thing about RNA viruses. RdRp enzymes are structurally conserved across viral taxa.
frontiersin.org/articles/10.33…
Read 7 tweets
Dr Able Lawrence🦉MD DM Profile picture
18 Mar
This is a thread on use of drugs for #COVID19
Hydroxychloroquine (Lupus, RA) Lopinavir/Ritonavir (HIV/AIDS) Remdisivir and Favipiravir (Ebola) and Camostat (Pancreatitis, Japan) are drugs that seem to have activity against SARSCov2
Some of these are used on Emergency Basis. 1/n Image
Potent nucleoside antiviral drug from Emory University shows broad spectrum activity against corona viruses including Remdisivir resistant strains. Acts by targeting RdRp to increase RNA mutation rates. @EmoryUniversity #EIDD2801 #COVID19
#coronavirus 1/n
news.emory.edu/stories/2020/0… ImageImage
Promising broad spectrum antiviral agent #EIDD2801 is active against #Remdisivir resistant strains. Indeed such mutations increase susceptibility which augurs well for combination use. It’s a prodrug gets converted to #EIDD1931 & increase mutations.
2/n
 biorxiv.org/content/10.110…
Read 4 tweets

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