A teaser on my post-COVID fatigue syndrome article #LongCovid
esp. on the cognitive difficulty (brain fog)
IMO, very little to do with your brain, a lot to do with your liver.
1. critical supply of 5-htp from liver to brain gets cut off, as tryptophan is depleted by IDO and TDO by continued hyperinflammation.
The brain gets very short on serotonin as a result.
2. a secondary possibility for some is the disruption of Ach anti-inflammation pathway.
Much of this is learned from very recent brain cancer research on IDO/TDO inhibitors, in which serotonin is found by cancer cells to evade immune response.
The good news is that there are some simple supplements that can be taken as a pre-pack to exercise/exertion that could alleviate/prevent the brain fog/fatigue greatly.
Will cover this in my blog article that's coming this week.
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Also, reportedly Ant wanted to issue consumer-debt backed ABS in China, which made regulators even more nervous.
3/ It seems that the regulators believed that Ant has the ambition to be a commercial bank, an investment bank, and maybe a shadow central bank in CNY.
The most optimistic timeline: FDA EUA at EOM Nov to the earliest.
Rolling out to 65+ yo in general public in mid-Dec to the earliest.
2nd shot administered in early Jan to the earliest.
Recipient developing protective level of antibodies in mid Jan to the earliest.
Thus, most 65+ yos will still need to social distance for Thanksgiving and Christmas.
And i still expect covid cases to peak in late Dec and early Jan, at a scale many times bigger than we have today.
more sophisticated Ab cocktails are probably needed 1 year from now. There will be an ongoing evolution of new antibodies and new vaccines in response to new mutations.
We definitely need more on-going genetic sequencing of new COVID cases.
In the mean time, anything that makes COVID milder helps us get through this pre-vaccine, pre-Ab period:
People ask me how Chinese managed to control COVID for the last few months.
Well, people there have to run mobile tracing apps on their cell phone 24/7, which generates a pass for them to access any transportation, restaurants, malls, hotels etc.
A relative of mine recently did a sight-seeing trip in China, and ended up having to run 4 tracing app on her phone.
One from China CDC
One from the cdc of the province she lives
One from the cdc of the destination province
One from the Hubei CDC for her 5hr layover in Wuhan
If any lab-confirmed covid cases has came in close proximity of her, the tracing app will turn red automatically as soon as the lab report comes out. And anybody who contacted her would have the tracing app turning orange.
Fasten your seat belt. Covid19 is going to explode in the US from now through the new year.
The worst of all, i am hearing a lot of anecdotes of primary-care physicians in smaller cities/rural areas managing covid symptoms as if it is flu.
Very little thoughts being put into anti-inflammatory and anticoagulant.
When its-just-flu bros get treated by its-just-flu physicians,
That's what I call a shitshow.
Death lags inflections by 4-6 weeks. Right now is not the time to be complacent.
A lot of lab resources and personalized care are needed to navigate the 2nd-3rd week of covid (hyperinflammatory and hyper-coagulation phase). Just imagine that big post Thanksgiving and post Christmas flux of elderly patients rushing the hospitals at the same time