1/ In honor of #WorldDiabetesDay2020, and to directly address two significant public health threats of the 21st century, I want to discuss very-low-energy-diets and low-energy-diets as a potential treatment for obesity and T2DM. [thread]
2/ Total Diet Replacement (TDR) strategies have been extensively studied and found to be an effective dietary intervention to promote a Calorie deficit and reduced food intake.
3/ I originally became interested in TDR interventions reading the many works of Dr. Thomas Wadden, demonstrating clinically significant short-term weight loss with VLEDs. [Tsai & Wadden, 2006]
1/ WHY INCREASING PHYSICAL ACTIVITY/EXERCISE SHOULD BE A GREATER FOCUS THAN LOSING WEIGHT:
I still think a weight-centric approach to managing chronic dz is the best approach, but if you are going to focus on ONE change in your life, I hope it is increasing PA.
[thread]
2/ To understand my point you need context. First, losing WT and maintaining it is hard. I could give you any number of obscure stats on this, but I think you all know from experience. The obesogenic environment (sedentary life + modern UPFs food) is unforgiving.
3/And while I think we should cont to manage our Wts the best we can (lifestyle/meds/surgery), THE SYSTEM is rigged against us. Until we address the systemic issues driving OB (food deserts, health inequity, poverty, agricultural subsidies, etc.) major changes will not occur.
In Young Adults, certain health factors predict the risk of mod-severe #COVID19:
👉BMI > 30
👉Fatty liver (increases risk 6-fold)
👉Ectopic fat in the kidney, albuminuria
1/ "MASK"ING THE CASE: WHY THERE SHOULD BE A UNIVERSAL MASK MANDATE
I have been fascinated by the discussion around mask use during the pandemic. Suffice it to say, the US' compliance has not been great considering the size of the current outbreak across the US states. [thread]
2/In fact, as recently as July 2020, there was a only ~48% chance everyone would be masked during five random public encounters.
A large number of people, including physicians, believe that obesity is a consequence of a person's moral character or poor choices. The reality could not be farther from the truth. Let's jump in...
There are many contributors to OB both int. as well as extnl factors. However, the OB epidemic is a relatively new phenomenon that has only been present since the 1970s. Most believe it is due to the convergence of our biology w/ modern food environ.
3/ We are consuming a lot more food. Our best calculations estimate the modern OB epidemic to be the result of an additional 200 kcal of food per day. H/t @KevinH_PhD and @whsource