One year ago today - before the rest of the world got to experience lockdown - the islands of Samoa locked down to defeat a different virus: measles


For those who speak German: We talk about this in a new @pandemiapodcast episode
For everyone: a thread
viertausendhertz.de/pan15/
@pandemiapodcast The outbreak in Samoa started in October 2019. As usual there are multiple, complex reasons that all led to vaccine coverage declining. There was complacency, there were structural changes in the health care system, there were anti-vaccine groups. And there was a terrible tragedy
@pandemiapodcast In July 2018, two children died just after receiving the measles vaccine. Nurses preparing the vaccine had accidentally mixed the powder with an anaesthetic instead of water. (They were sentenced to 5 years in prison.)
The deaths further fuelled fears about vaccines.
@pandemiapodcast Vaccination programs were suspended for months.
The result: Vaccine coverage slipped to low levels, really low levels.
In 2013 99% of Samoan infants received the 1st dose of MMR, in 2018 it was just 40%. Coverage with the 2nd dose went from 87% to 28%. (thelancet.com/journals/lanin…)
@pandemiapodcast Then measles was introduced to Samoa, probably by a traveller from Auckland, New Zealand, where measles was spreading. (Health experts had already warned of this.)
The virus spread like wildfire amongst the unvaccinated in Samoa.
@pandemiapodcast (This had happened before: In 1893 the steam ship Upolu brought measles to Samoa for the first time, also from New Zealand. “from reports obtained from missionaries and others, no fewer than 1,000 of the entire population of 34,500 died from measles” ncbi.nlm.nih.gov/pmc/articles/P…)
@pandemiapodcast As more and more people got sick and the death toll climbed, Samoa decided to lockdown the country for two days: schools and shops were closed, national exams postponed, travel and public gatherings restricted.
@pandemiapodcast In a huge immunisation campaign, teams went from house to house, vaccinating people. Residents hung red flags or sheets out of their windows to indicate anyone in the house who was not vaccinated and at risk.
@pandemiapodcast The vaccination campaign helped Samoa reach 95% coverage and the outbreak was declared over soon after.
But the impact was devastating. There were more than 5700 measles cases.
83 people died, the vast majority children under 5 years of age.
@pandemiapodcast People forget how deadly measles is.
Not just complications like pneumonia or encephalitis (incl. years later the terrible, deadly, incurable SSPE - subacute sclerosing panencephalitis).
Measles also wipes out part of the immune memory, leaving kids vulnerable to other infections
@pandemiapodcast Samoa has a population of around 200,000 people. Can you imagine what it means for more than 80 children to die there in just a few weeks?
In Berlin, where I live, the equivalent would be more than 1000 children dying within just a few weeks.
@pandemiapodcast So that is the power of measles.
And that is the power of immunisation.
@pandemiapodcast Then measles was introduced to Samoa, probably by a traveller from Auckland, New Zealand, where measles was spreading. (Health experts had already warned of this.)
The virus spread like wildfire amongst the unvaccinated in Samoa.
@pandemiapodcast (This had happened before: In 1893 the steam ship Upolu brought measles to Samoa for the first time, also from New Zealand. “from reports obtained from missionaries and others, no fewer than 1,000 of the entire population of 34,500 died from measles” ncbi.nlm.nih.gov/pmc/articles/P…)
@pandemiapodcast As more and more people got sick and the death toll climbed, Samoa decided to lockdown the country for two days: schools and shops were closed, national exams postponed, travel and public gatherings restricted.
@pandemiapodcast In a huge immunisation campaign, teams went from house to house, vaccinating people. Residents hung red flags or sheets out of their windows to indicate anyone in the house who was not vaccinated and at risk.
@pandemiapodcast The vaccination campaign helped Samoa reach 95% coverage and the outbreak was declared over soon after.
But the impact was devastating. There were more than 5700 measles cases.
83 people died, the vast majority children under 5 years of age.
@pandemiapodcast People forget how deadly measles is.
Not just complications like pneumonia or encephalitis (incl. years later the terrible, deadly, incurable SSPE - subacute sclerosing panencephalitis).
Measles also wipes out part of the immune memory, leaving kids vulnerable to other infections
@pandemiapodcast Samoa has a population of around 200,000 people. Can you imagine what it means for more than 80 children to die there in just a few weeks?
In Berlin, where I live, the equivalent would be more than 1000 children dying within just a few weeks.
@pandemiapodcast So that is the power of measles.
And that is the power of immunisation.
@pandemiapodcast (If I had kids and they would ask me what a vaccine is, I would probably tell them it gives them superpowers: It makes them invisible to the virus, so that it cannot find them.
And the best thing: If enough kids are invisible, the virus won’t bother coming to a place at all.)
Thanks to @CT_Bergstrom, @ProfHeidiLarson, @deerbrian, @AbOsterhaus and @who’s Rasul Bhagirov, who all contributed to the episode!
The podcast is a cooperation with @riffreporter who help finance it with money from the Klaus Tschira Stiftung.

riffreporter.de/corona-virus/p…

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More from @kakape

4 Dec
@WHO is concerned that there is a growing perception that the pandemic is over”, says @drtedros at #covid19 presser. "The truth is that at present, many places are witnessing very high transmission of the virus."
@WHO @DrTedros "We know it has been a hard year and people are tired, but in hospitals that are running at or over capacity it's the hardest it can possibly be”, says @DrTedros. "Please be careful. Think of health workers and act for the greater good, because it will save lives and livelihoods"
@WHO @DrTedros "The pandemic still has a long way to run and decisions made by leaders and citizens in the coming days will determine, both the course of the virus in the short term and when this pandemic will ultimately end”, says @drtedros. "Fighting this pandemic is everybody's business."
Read 21 tweets
1 Dec
I don’t really remember how we marked the beginning of a new week in pre-pandemic times, but these days we celebrate “good news on vaccines” Mondays, followed by “not so good news on global #covid19" Tuesdays.
That’s to say: the WHO’s weekly sitrep is up. Quick thread
Big picture:

3,935,330 new cases and
69,916 new deaths
were reported to @WHO last week.
That means deaths have risen for a sixth week (+3%), but cases are down 4% from last week.

It is a huge amount of death and disease from one little pathogen.
@WHO Number of new #covid19 cases finally going down after two months of increases may sound great.
The problem is that the data includes the craziness of US Thanksgiving numbers.
US case number is basically the same as last week, when it should probably be a lot higher.
Read 7 tweets
1 Dec
Here we go. Moderna and Biontech/Pfizer have today submitted the data on their #covid19 vaccines to the EMA to request a conditional market authorisation. EMA spokesperson told me they think a decision could come “by the end of this year at the earliest”.
If data submitted on Biontech vaccine is robust enough, “EMA’s scientific committee for human medicines (CHMP) will conclude its assessment during an extraordinary meeting scheduled for 29 December at the latest”

ema.europa.eu/en/news/ema-re…
If data on Moderna vaccine is robust “EMA’s scientific committee for human medicines (CHMP) will conclude its assessment during an extraordinary meeting scheduled for 12 January at the latest”.

ema.europa.eu/en/news/ema-re…
Read 4 tweets
30 Nov
“Last week saw the first decline in newly-reported #covid19 cases globally since September, due to a decrease in cases in Europe”, says @DrTedros at @WHO presser. Says it’s "thanks to the effectiveness of difficult but necessary measures put in place in recent weeks”.
@DrTedros @WHO #covid19 cases are still increasing inmost other regions, says @drtedros and warns that gains can easily be lost, especially with the holiday season coming up. "This is no time for complacency."
@DrTedros @WHO "We all need to consider whose life we might be gambling with in the decisions we make”, says @DrTedros. “We all want to be together with the people we love during festive periods. But being with family and friends is not worth putting them or yourself at risk."
Read 22 tweets
30 Nov
More stunning data out from Moderna’s vaccine trial today:

Of 196 #covid19 cases
185 were in placebo group
11 in vaccine group
- 94,1% efficacy

All 30 severe #covid19 cases were in placebo group
- so that’s, well, 100% for now

There was one #covid19 death in the placebo group
“Efficacy was consistent across age, race and ethnicity, and gender demographics”


The 196 #covid19 cases included:
33 in people 65+
42 in people "identifying as being from diverse communities”
Moderna says it will submit today for EUA at FDA and for conditional marketing authorisation at EMA.

FDA meeting to review safety and efficacy data likely on December 17.

Press release here (and yes, it’s another “vaccine news by press release Monday”):
investors.modernatx.com/news-releases/…
Read 8 tweets
29 Nov
Interesting piece by @mattapuzzo and others at @nytimes looking at the list of seven demands Trump conveyed to @WHO before he announced withdrawal. No clear strategy apparent. “It was all about my country, my politics, my election”, says @LawrenceGostin. nytimes.com/2020/11/27/wor…
“The third item asked Dr. Tedros to say that countries were right to consider travel restrictions during the pandemic ... Dr. Tedros was wary of being drawn into the American presidential campaign, where travel restrictions were a rallying cry for the Trump campaign.”
“The American requests also called for the W.H.O. to pre-qualify coronavirus drugs and vaccines for use around the world once they were authorized by major regulators in the United States, Canada, Europe or Japan.”
Read 4 tweets

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