.@NYGovCuomo asks Dr Fauci: When is 75-80% of population being vaccinated feasible?
Dr Fauci: Going to be entirely dependent on how well we do - how I do, you do - on getting message out about how important it is for people to get vaccinated. (1)
Dr Fauci to Cuomo on #covid19 vaccination timeline:
-By end of Dec, substantial proportion of health-care providers and people in nursing homes will be vaccinated
-By the time you get to beginning of April, you'll start to get people who have no high priority (2)
Dr Fauci: "In a full-court press," through April, May and June, by the time you get to the summer (w prime-boost doses & 7-10 days for immunity), by the "core of summer, end of summer, start of third quarter of 2021, we should be in good shape. That's what I'm hoping for." (3)
Dr Fauci also shares some of his NY comfort foods (specifically from Bensonhurst Brooklyn), at @NYGovCuomo's urging:
Nathan's hot dogs & a 'steaming' pastrami sandwich
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This appears to be an explainer of a change that happened in Pfizer's #covid19 vaccine supply expectations between Sept. 9 and Nov. 9, which flew under the radar because Pfizer reduced the 2020 supply expectation in the same release it reported 90% efficacy for the vaccine (1)
In Aug & Sept, Pfizer was forecasting up to 100m doses of its #covid19 vaccine by the end of 2020, and up to 1.3B doses by the end of 2021: (2)
Nov 9, when Pfizer reported its first phase 3 efficacy data, it included the new (reduced) forecast for supply: (Link here bc the dateline isn’t visible in this photo: pfizer.com/news/press-rel…) (3)
.@HallieJackson says Regeneron Chief Scientific Officer Dr George Yancopoulos coming up next with her on @MSNBC
@HallieJackson asks: What do you know about these 3 drugs together?
GDY: Our antibody cocktail essentially just mimics the normal immune system... theoretically there should not be any additional interactions with these other medications than you'd have with your own antibodies.
Yancopoulos also notes that bc Regeneron's antibody cocktail boosts the immune response, the concern about giving immunosuppressive dexamethasone earlier in course of disease may be lessened.
A few takeaways: it’s not clear what the issue is, if it will have a meaningful impact on AstraZeneca’s trial, or the trials of other #Covid19 vaccine makers.
(Though stocks are reacting at least in short term as if this is a boon for Moderna, Novavax etc)
Better takeaway here from @natashaloder, especially in this time of fear of a rushed vaccine:
Dr Fauci, at an Atlantic event, was just asked about the criticisms coming at him from the Trump Administration:
Fauci: "It is a bit bizarre, I don't really fully understand it." (More)
Fauci on the list from Trump Administration circulated alleging what he got wrong on #COVID19: "If you sit down and talk to the people involved in that, they are taken aback by what a big mistake that was." (2)
Fauci: "If you talk to reasonable people from the White House, they realize it was a major mistake on their part bc it doesn't do anything but reflect poorly on them. I can't figure out in my wildest dreams why they would want to do that." (3)
Moderna’s plan to expedite clinical development of #COVID19 vaccine: start phase 2 with safety data from phase 1; phase 3 with safety of phase 2 + efficacy data from phase 1 to guide dose selection (2)
Moderna’s phase 2 #COVID19 vaccine trial will enroll 600 people and test doses of 50 and 100 micrograms; the planned high dose was revised (from 250 micrograms) based on phase 1 results (3)
New open letter from Gilead CEO on remdesivir data: “We recognize the limitations of these compassionate use data from a purely investigational perspective, while knowing they are of the greatest significance for the patients whose symptoms improved. gilead.com/stories/articl…
Gilead CEO Dan O’Day: “The results, which cover 53 of the first patients to have been treated in the program, show that the majority demonstrated clinical improvement after taking remedesivir.”
Also notes 7 clinical trials initiated,data expected end of April in severe #COVID19
O’Day: “With every day that goes by, the desperate need to equip healthcare workers and their patients with a safe, effective treatment becomes more pressing. We are working with intense speed to determine whether remdesivir could be an option...”