#Azithromycin associated w/ #COVID_19 associated pulmonary #aspergillosis. OR 3.1 (1.1-8.5). Just published in @CMIJournal (bit.ly/2JN1fDS). Could it be a risk factor ? More on this hypothesis ⬇️ 1/5 
#Azithromycin >1500mg in humans = inhibition of oxydative burst in #neutrophils up to 28 days after last dose. By Culic et al. (bit.ly/3mPkYkd) 2/5
#Neutrophils = first barrier against fungal infection. Oxydative burst necessary for NETs formation. Genetic defect in oxydative burst leads to CGD with well-known increased susceptibility to #aspergillosis (bit.ly/2VJu1aN). 3/5
#Azithromycin could further promote Aspergillus colonization by altering the lung #microbiome (bit.ly/2VNvzR0) 4/5
In COVID-19 critically ill patients, susceptibility to #CAPA is most likely multifactorial, here’s the proportion of #CAPA among patient who received #azithromycin, #corticosteroids or both in our cohort w/ @a_alanio. More in vitro/in vivo studies needed 5/5
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