Discover and read the best of Twitter Threads about #Azithromycin

Most recents (24)

An evaluation of mass #azithromycin distribution on respiratory #virome suggests children have ⬇️non-SARS coronavirus viral load in communities receiving azithromycin compared to placebo. These findings are intriguing, with some important considerations.
academic.oup.com/cid/advance-ar…
This is a non-prespecified analysis from the #MORDOR study. These data pre-date COVID19 emergence by years. Most importantly, this paper does not say anything about whether azithromycin does or does not work for COVID19.
Mechanism unclear (and this study is not designed to address that). Azithromycin has anti-inflammatory effects, so could be related to that. Could be some secondary effect of reducing bacterial effect, or an off-target effect on viral replication. Also could be chance.
Read 5 tweets
Like many, I’ve had some extra fee time these days... After rebinging @theofficenbc and #theofficereunion I was inspired.

A thread of Trump’s handling of the #coronavirus (#COVID19) pandemic, as told by Michael Scott. #TheOffice
Way back in 2018, Trump decided it was a good idea to disassemble the #Pandemic Response Team – created by the Obama administration in case there was “an airborne disease that is deadly.” This can’t go wrong! #thiswaspreventable
Trump does nothing to replace this. He plays golf and insults people on Twitter – just the normal things that presidents do right?
Read 52 tweets
Let’s talk about the zinc. This supplement has gone viral together with #hydroxychloroquine and #azithromycin hype, and has been promoted without scientific evidence.
thread🔻
Most Zinc supporter refer to this article published on PLoS Pathogen in 2010, which described an in vitro inhibitory effect of Zn against SARS-CoV. Author also suggests the RdRp-dependent potential mechanism. Can this be translated to SARS-CoV-2? Let’s dive in. Image
The sequence & structural homology of RdRp between SARS-CoV and SARS-CoV-2 is high. Both have structured Zn ion, which looks like a cofactor critical for its activity. But the pharmacological perturbation with excessive Zn ion is largely unknown. science.sciencemag.org/content/early/… Image
Read 9 tweets
NYU Med school study of ~ 900 #Covid_19 patients. Patients receiving #Hydroxychloroquine, #azithromycin and zinc sulfate had a 1.5 times greater chance of recovering & were 44 percent less risk to die, compared to those without zinc. news.yahoo.com/zinc-hydroxych… ImageImage
Administration of the HCQ+AZ combination BEFORE #Covid_19 complications occur is safe and associated with a very low FATALITY rate in patients. Interesting article on #Hydroxychloroquine prophylaxis outcome. Assessing all POSSIBILITIES.
sciencedirect.com/science/articl… Image
Read 4 tweets
1/ Little Thread about all The Misleading Medical Information still floating around about #Hydroxychloroquine & #Chloroquine & #Azithromycin & #ZelenkoProtocol - by 1 doctor - @zev_dr & #Remdesivir & more

Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
2/ #TrumpIsTheWORSTPresidentEVER

First, why it has been political all the way, suspected from day one:

"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"

vanityfair.com/news/2020/04/i…
3/ #Trump2020

Indian PM Modi and Trump held a rally together.

"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"

bbc.com/news/world-sou…
Read 42 tweets
1) I'm reconsidering my opposition to anti-vaxxers and homeopathy, among other things. Hell, I might even give the young earth perspective another look.

I've been a seriously committed opponent of those viewpoints for over twenty years, and for (I think/thought), good reason…
2) You know, I wonder if (natural) tobacco is actually even harmful. Why is it such a big crime to grow it at home? 🤨 I know, I know, this is all nuts. Stick with me anyways, though, mmmkay? This might be fun…
3) I studied each of these issues at one time or another. I mean, I researched them hard for at least a year. (Well, except the tobacco thing; I never doubted that tobacco was harmful, and I still don't, not really.) …
Read 21 tweets
a "highly-(self)-cited" preprint from #raoult suggesting in vitro synergy of #hydrodroxychloroquine + #azithromycin against SARS-CoV-2 got accepted by Microbial Pathogenesis.

sciencedirect.com/science/articl…

a 18-day "serious" peer review happened

Let's see what we have(troll face)🔻
This paper is more like a beautiful mathematic proof - concise but "brilliant" -

"we proved that synergy is true. period"

Abstract: 93 words
Result: 143 words

🤣🤣🤣
Back to science, what is synergy?

In pharmacology, synergy is the observation that the outcome of a combination greater than individual. In plain word, 1+1 > 2.

Here is Fig 2A. A: az, H: hcq. number = concentration in uM.

WHERE IS THE Ct for HCQ & AZ ALONE ⁉️
Read 8 tweets
🚨BREAKING: @US_FDA now warns that people should NOT take #chloroquine or #hydroxychloroquine—hawked by @realDonaldTrump—to treat #COVID19 outside a hospital or clinical trial, citing reports of “serious heart rhythm problems.”

As I warned 5 WEEKS ago.🤬
washingtonpost.com/world/2020/04/…
Both #chloroquine and #hydroxychloroquine can alter the heart’s normal rhythm, leading to FATAL cardiac arrest.

Co-administration with #azithromycin (“Z pack”) can INCREASE the risk for this fatal side effect.🤬

FDA shockingly gave #hydroxychloroquine “emergency use authorization” (not a formal approval) for use in #COVID19 with ZERO supportive clinical evidence.

Did FDA cave to pressure from Trump⁉️

Read 3 tweets
6 months ago how many of you had heard of #Hydroxychloroquine?
Well I knew about it
Here's my story as I support @realDonaldTrump and his push for the use of this drug to treat #COVID19
I was DX with Chronic Late Stage #LymeDisease around 2014. I've probably had it my entire life. It lies dormant in your body for many years waiting to rear its ugly head.
upi.com/Archives/1990/…
9 yrs ago it activated in me.
Like many Lymies I struggled getting my Dr to believe me and this complicated disease. He refused to listen, denied the existence of it and eventually kicked me out of his practice of which I had been a patient 14ish yrs
The mockery of patients is real.
Read 17 tweets
@Acosta 1/ #bs💩. You and yours got creamed. Deservedly.

Now, why not do some real journalism? Are the #ICUs using #vitaminC drips to hasten the healing and protect the lungs of those on ventilators.

Your task, Jim, should you chose to actually do journalism, is to find the medical..
@Acosta 2/ articles that I am telling you are out there and see if #CDC offered guidelines for those patients. 2) More research—has the @CDC informes #AfricanAmericans that they need to boost their immune systems with mega doses of #VitaminD? Do the research. Find out why that is ...
@Acosta @cdc 3/ needed. 3) Why aren’t #Fauci & the #CDC recommending #HydroxychloroquineAndZinc? #azithromycin is helpful, but why are the other two necessary? So your research. Find out. I know—you need to. If you ( #MSM) DO know any and all of these things, and have not spoken out, the...
Read 5 tweets
🚨BREAKING: major safety issues seen in a study in #Brazil of #chloroquine treatment for #coronavirus. 25% of patients taking the higher dose of chloroquine recommended by #China had irregular EKGs that increase risk of a fatal heart arrhythmia. 17% DIED.

nytimes.com/2020/04/12/hea…
🔥One of the authors of the study, Dr. Marcus Lacerda, said that his study found that “the high dosage (of #chloroquine) that the Chinese were using is very TOXIC and KILLS more patients.”

Yet @realDonaldTrump–who is NOT a doctor–keeps pushing its use.🤬

~50% of patients were given 450 mg of #chloroquine 2x/day for 5 days, while the rest were given 600 mg for 10 days. Within 3 days, heart arrhythmias were noted in patients at the higher dose. By the 6th day, 11 patients had DIED, immediately ending the high-dose treatment arm.
Read 5 tweets
Thread
I have good news & bad news about #Hydroxychloroquine #HCQ

Good: The French study from Dr Didier #Raoult & 1 of 2 Chinese studies demonstrated efficacy BEYOND placebo. Not anecdotal but not large.

@TuckerCarlson
@RudyGiuliani
@kilmeade
@IngrahamAngle
@DrOz
@drdrew

RT Image
2
More good news: The efficacy was for #HCQ in combination w/ #Azithromycin. #DrZelenko adds #Zn. In 3-4 days viral load was reduced below placebo. Hospitalization time reduced. Pres Trump was told a large clinical trial was starting Mon. March 30 in NYC of 1K patients.

RT Image
3
More good news: @DrAnthonyF said at briefing last week for us to track the trials (plural) at clinicaltrials.gov

The bad news:. It's Apr 12 and if you look under Hydroxychloroquine or HCQ in NY State, it shows no such trial has started for #Covid19. Recruiting Not Started
Read 6 tweets
(1/) An update of analysis of Dr. Raoult’s #hydroxychloroquine #azithromycin trial on 1061 patients.
mediterranee-infection.com/pre-prints-ihu/
(warning: it’ more like conspiracy theory)
(2/) Actually the preprints have two versions.

“Version 2”
mediterranee-infection.com/wp-content/upl…

Final version
mediterranee-infection.com/wp-content/upl…

There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
(3/) Another difference is the way that NEWS scores were presented.

Version 2. Mean-Sd-median-range.

Final version. Low-medium-high brackets.
Read 12 tweets
More & more drs are treating patients with #hydroxychloroquine & #azithromycin & some with #zinc w/very good results..here is a list with links: @threadreader app unroll pls.
Dr. Stephen Smith, Infectious Disease Expert uses HCQ/Azithromycin to treat 70 patients = no intubations “a gamechanger” “the beginning of the end for CV”:
HCQ/AZ & DIABETICS...Dr. Stephen Smith’s findings:
Read 20 tweets
kanye west was right when he said

“America eats its babies”
mofos in Hollywood & mofos in politics been eating babies for years. literal years. look up #Adrenochrome
last time I tweeted about this I got targeted lol but it’s ok. times are a lil different now.

back then I didn’t know about Adrenochrome but it was the missing piece.
Read 39 tweets
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts

Will add as we go along

Feel free to add your own observations/experiences

#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients

#covidclinicalpearls /3
Read 66 tweets
@afneil The focus on ventilators is about as useful as focusing on whether we have enough coffins. There are more valuable interventions that are being totally ignored in uk at present. Let's run through them:
@afneil 1. Early intervention at home for ALL who develop mild #COVIDー19 symptoms - give them ALL a 5 day course of #chloroquine or #Hydroxychloroquine - this will prevent vast majority of severe cases needing to anywhere near a hospital
@afneil 2. Give PEP - post exposure prophylaxis of #chloroquine or #Hydroxychloroquine to the household members in a home where a person develops symptoms. Evidence is that most transmission is within the household. So stop the virus there!
Read 13 tweets
THREAD 1/X Data available from NEW Chinese #Hydroxychloroquine #SARSCoV2 study conflicts with recent French #Hydroxychloroquine (and #Azithromycin) study touted by US politician. zjujournals.com/med/article/20… and mediterranee-infection.com/wp-content/upl… My thoughts:
2/X Both are small pilot studies and REQUIRE FURTHER VALIDATION. Viral load is the endpoint (not clinical outcome). This is important regardless because decrease shedding duration may have important #publichealth implications, and viral burden could impact cytokine storm risk
3/X French study is non-randomized, new Chinese study is randomized. This resulting imbalance in patient characteristics/disposition in French study raises lots of questions. Chinese study only published abstract, so more info is needed, but would tend to have more faith in it
Read 13 tweets
Several studies in situ in Italy suggest that #hydroxychloroquine and #azithromycin have determinant effects over the ribosome RNA poly3' aaa sensitive polymerases, that are protein assembly units from RNA messenger into proteins.
It appears based on evidence (n=250), [not a randomised double-blind studies], that these two drugs have a synergistic effect in the hosts cells that make the virus partially unable to kidnap the ribosomes polymerase protein assembly of our cells.
Hydroxychloroquine is a zinc Inophore, which means it allows the external Zn to go inside the cell. Zn by itself is not easy to be carried inside the cells, however high amounts of Zn+2 inside the cell have the ability to reduce attachment of RNA 3'aaa dependent polymerases.
Read 7 tweets
#COVID19 QTc prolongation aside, there are some serious issues with the 100% cure rate being touted for #hydroxychloroquine and #azithromycin combination in bit.ly/2Jae3zS:

@realDonaldTrump @elonmusk
1. They are measuring virologic clearance (-ve PCR), not clinical cure
2. They cherry picked the data - excluded 4 patients upgraded to ICU and 1 that died; stopped at day 6 on this graph because that was the day with 0% +ve samples (some turned +ve after day 6
3. Virologic cure does not = clinical cure. The authors own excluded death patient had -ve PCR. Many cases of -ve PCR turning +ve later.
Read 6 tweets
Ppl ask, why not try #Hydroxychlorquine and #Azithromycin for #SARSCov2 #COVID19. Here is some important info to know about the study sciencedirect.com/science/articl…

1. 20 HCQ pts (200 mg TID) & 16 controls with SARSCoV2
2. Pts w/ URTI, LRTI, or asx
3. 6 HCQ pts received Azithro x 5 d
4. Pts received Azithro to prevent bacterial superinfxn
5. At day 6 post-inclusion 70% of HCQ pts were virologically cured vs 12.5% in control
6. At day 6 100% (6 pts ) with HCQ+Azithro were virologically cured vs 57.1% of HCQ only (14 pts) vs 12.5% in control (16 pts)
Although this data is potentially promising there are a few things to consider
1. This study is not powered for efficacy
2. Small sample size
3. No long term follow-up (although virologically cured unknown if it returned)
4. Unclear info on pt co-morbidities who received drugs
Read 5 tweets
Is #azithromycin (an antibiotic, not an antiviral) + #chloroquine (an antimalarial) effective?

Maybe, maybe not. This is why clinical trials are vital... even when the outcomes are negative.

nytimes.com/2020/03/18/hea…
meanwhile, when we have political leaders who don't understand science and the necessity of randomized clinical trials to demonstrate safety/efficacy...

nytimes.com/2020/03/20/hea…
here's the link to the clinical trial on hydroxychloroquine + azithromycin... NOT randomized, NOT blinded, only N=6 pts treated with combination treatment = take the results with a HUGE grain of salt

mediterranee-infection.com/hydroxychloroq…
Read 6 tweets
This thread is documentation of #viral, #PseudoScience & #irrational information circulating around in the midst of #CoronavirusOutbreakindia.
Starting from @AltNews report debunking uniform latitudes of places where #Corona came.

altnews.in/places-most-af…

@ScienceMarchMum
Coronavirus: Is drinking cow urine any help?
By Reality Check team @BBCNEWSIndia1

bbc.com/news/amp/world…
China culled around 18,000 chickens in Shaoyang city in the southern province of Hunan as a result of a flu outbreak. Rumours in India started circulating, that broiler chicken has been infected with Coronavirus and people should avoid consuming it.

altnews.in/coronavirus-in…
Read 39 tweets

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