@gernot_ruzicka 1/ This is a very high proportion. Other studies show lower proportions. Unfortunately a Cochrane-Review contains only Studies published until April 27 (I suggested an update) cochrane.org/CD013652/INFEC….
@gernot_ruzicka 2/ In my opinion, to assess the proportion of false negatives right is depending on good validation of the used test wich implies serial testing (on a time axis) of known symptomatic and asymptomatic cases, defined by positive mRNA PCR (nasopharyngeal swab) or other criteria.
@gernot_ruzicka 3/ Preferably validation cases should be of the same age as the participants of the study group the test is used on. From the information available of medrxiv.org/content/10.110… the used ABCORA test seems not to have been validated in an optimal way for the use in this study.
@gernot_ruzicka 4/ The authors of medrxiv.org/content/10.110… should explain in precise detail how the used serologic test has been validated, what bias has to be expected from that, and how they take this into account in their analysis and conclusions.
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