TAXI 🚕 & TRANSIT RISK—We know #SARSCoV2 is airborne. But how survivable inside a car?

➡️Well, study now reports a car driven 15 minutes by a mildly infected #COVID19 driver (no cough/fever) left infectious virus inside the car’s air **even 2 hours** after exiting—AC was on too!
2) Windows of the car were up. And unclear if the AC was on outside venting mode or not.

The air sampler was attached to the sun-visor of the passenger seat.
medrxiv.org/content/10.110…
3) to be clear—the virus was captured from the 2 hour old air, transported up to another 30 mins, and virus shown to be cultured — which means able to be grown in the lab, which means it was still infectious.
4) Thus, for public transit and taxi, we really need to OPEN WINDOWS. Ventilation is so critical. Don’t rely on masks alone in these cars — especially if many Uber or taxi drivers might not wear a mask when alone while the car is not in service. OPEN THE WINDOW 🪟 please!
5) An older aerosol study indicates that coronavirus may be persistent and stable up to 16 hours in stagnant air. Typical air exchange every 20 min to 4 hrs, depending on ventilation, but this is why it’s so tricky of a virus. #COVID19
6) How sure are we about the 16 hours?

Mechanically generated aerosol airborne #SARSCoV2 retained ability to infect cells for at least 16 hrs. More hardy and robust than many other coronaviruses.

Here is the CDC published journal report.

wwwnc.cdc.gov/eid/article/26…
7) What about opening windows? Look how more windows open, lower the risk of DRIVER TO PASSENGER transmission.

advances.sciencemag.org/content/7/1/ea…
8) VENTILATION is key. Both ventilation and masks needed to reduce risk indoors. But most buildings not ventilated well enough.

9) Japan assumed it was airborne from the very beginning. Hence their mask culture and focus on air flow. Here is how to ventilate your school classrooms if unable to open window. #COVID19

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More from @DrEricDing

18 Jan
WORRISOME ON *E484* MUTATION—New study from blood of 44 people infected in 1st wave in S Africa🇿🇦 was tested against new #SARSCoV2 variant #B1135 (501Y.V2)—found antibodies from **21 of 44 did not recognize** the new B1125 variant—Almost half! #COVID19 🧵
Image
2) This new E484K study is by @nicd_sa - respected research group. That said, antibody immunity is not all of immunity. T cells also offer spike protein recognizing immunity too (not measured).

Meanwhile—other studies on E484K immune escape—it’s in both 🇿🇦 & Brazil 🇧🇷 variants.
3) Why are we so worried about E484K? In another recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies in 9 of 11 patients, some with 10x reductions in neutralizing ability! Image
Read 5 tweets
18 Jan
BREAKING—new #B117 variant & vaccine data from 🇬🇧 research lab shows mutations in B117’s spike protein yields a ~3.8x reduction in efficacy of vaccine-generated neutralization antibodies compared to wildtype (WT) #SARSCoV2 strain. 10 of 15 people had >3x lower neutralization. 🧵 Image
2) Notably, @GuptaR_lab studied 15 people who had Pfizer mRNA vaccine against pseudo virus bearing Spike protein w/ mutations in B117 variant (del69/70, del 144/145, N501Y, A570D, P681H, T716I, S982A, D1118H). They found a modest reduction in efficacy.
3) paper pending—among 15 individuals with neutralisation activity 3 weeks after the Pfizer mRNA vaccine (immunity has already kicked in), 10 showed >3-fold reduction in efficacy of antibodies against B.1.1.7 mutant.

➡️The highest was *6x* reduction in neutralization. #COVID19 Image
Read 6 tweets
18 Jan
LET THIS SINK IN: So many people have died in Los Angeles that officials have suspended air-quality rules that limit cremations because current 2x deaths is “leading to hospitals, funeral homes & crematoriums exceeding capacity” unable to clear backlog of dead bodies. #COVID19 Image
2) And the LA County order says there's another surge of deaths that's approaching, fueled by the gatherings that took place over the New Year's holiday.

The emergency order will be in effect for 10 days and can be extended, the agency said.

google.com/amp/s/amp.cnn.…
3) Same time, LA County has historically had bad air pollution which damages the lungs. But lung is also one thing COVID damages the most... thread 🧵 below...
Read 5 tweets
18 Jan
LONG COVID—30% of hospital recovered #COVID19 patients end up back in hospital in <5 months; up to 12% die of complications. “we really need to prepare for #LongCovid. It’s a mammoth task to follow up w/ these patients, but monitoring needs to be arranged”
telegraph.co.uk/news/2021/01/1… Image
2) “Researchers at the UK’s Leicester University and the Office for National Statistics found that out of 47,780 people discharged from the hospital, 29.4 percent were readmitted within 140 days, the Telegraph reported.
Of the total, 12.3 percent succumbed to the illness.
3) “Many people who suffer long-lasting effects of the coronavirus develop heart problems, diabetes and chronic liver and kidney conditions.
Read 7 tweets
18 Jan
BREAKING—At 10:20am, Capitol Hill staffers received message:

“All buildings within the Capitol Complex: External security threat, no entry or exit is permitted, stay away from exterior windows, doors. If outside, seem cover. USCP”

➡️ Inauguration rehearsal also evacuated.
2) There is a fire, unclear if accident or something worse.
3) there is a fire a few blocks away.
Read 7 tweets
18 Jan
BREAKING—FBI has charged & have obtained an arrest warrant for 22-year old woman suspected of stealing @SpeakerPelosi’s laptop during the Jan. 6 Capitol siege with the intent of selling the device to Russia’s foreign intelligence services.
google.com/amp/s/www.inqu… Image
2) In an affidavit filed late Sunday evening, agents said they were contacted by the former romantic partner of Riley June Williams, 22, who recognized her in footage shot during the insurrectionist attack by the British network ITV.
3) Williams’ ex also reported having seen another video showing Williams pocketing the computer from Pelosi’s office and told investigators that Williams had said she intended to send it to a friend in Russia who would arrange the transfer to the SVR, Russian equivalent of CIA.
Read 4 tweets

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