1/ Some preliminary data from the #EatingWindowExperiment while we wait for the labs to come back.

These are the mean avgs for each period taken over the last 3 days of each phase (wake/7am/9am/2pm/7pm/10pm) compared.

Needless to say, this is some fascinating stuff...
2/ I was taking glucose and ketones (BHB) via @KetoMojo, lipids via CardioChek from @ptsdiagnostics

Where my test and meal times were the same, I'd take the blood test just before the meal.

(For study design, see cholesterolcode.com/eating-window-…)
3/ Again, I'm eating exactly the same thing in each phase, exercising the same, sleeping the same, etc -- the only difference is in the 10.5hr window my meals are 5 hours apart. In the 4.5hr window my meals are 2 hours apart.

(I added the 0.5 to reflect eating time of last meal)
4/ A number of interesting things jump out right away:

- Ketones climb in the 5hr gap for the 10.5, but climb higher for the 4.5 into the evening. This doesn't seem surprising at first given total fasted time.

However -- note they tighten up again into the morning...
5/ So while it might be tempting to assume a perpetual rise in ketones as the time elapsed since the last meal, this provide further data on the impact of sleep/morning cycle influence. Naturally, I'd love to be able to track various endocrine levels around the clock too.
6/ Super fascinating to watch total, HDL, and Non-HDL cholesterol levels, particularly when comparing the morning portion of wake/7am to 9am/later between each phase. Quite a difference to observe in the gap between the 4.5 and 10.5 windows earlier in the day.
7/ The triglycerides rising substantially post prandial was completely unsurprising (see my endless previous comments and blog posts on this topic, particularly for low carbers)

However, I was impressed to see how alike these trajectories were to each other later in the day.
8/ Note I do have a few "<50" readings that I converted to 45 in the TG (hence my calling it a "proxy") which was also used in applying the Friedewald calculation to LDL in this set of graphs as well.
9/ Lastly, while I will say it hasn't been the most pleasant exercise to extract that much blood from my fingers repeatedly each day (must fill a 40 uL capillary tube for CardioChek per test), I'm extremely thankful to have this data for comparison before the big labs come back.

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More from @DaveKeto

21 Jan
1/ Well... this is awkward...

I'm gaining weight on my "bonus" carb-swap phase in spite of it being isocaloric and everything else being nearly identical (exercise, sleep, supplements, even liquid consumption) w/ prior keto phases.

And I'm gaining it pretty fast, actually... ImageImageImage
2/ And actually, the "low carb" phase is technically slightly lower in calories than the keto phase.

And this experiment is as controlled as I get
- Fixed eating times with fixed meals (9am/2pm/7pm)
- Fixed exercise (walking) with same route and time (~3pm)
- Comparable sleep
3/ Sure -- like many reading this, I'd assume this is in large part glycogen and water gain. But I'll concede this is impressively fast given I'm at maintenance level of calories -- which was literally just demonstrated in the run-up phases before this one. Image
Read 4 tweets
20 Jan
1/ #ReadingThread

This paper by @zinocker, @kariannesve, @simondankel is proving an interesting read. Before I get too much further, I'm going to turn it into a "reading thread" and post some of these quotes as I go...

(Big hat tip to @bigfatsurprise) academic.oup.com/ajcn/advance-a…
2/ "In this paper we propose a novel model, the homeoviscous adaptation to dietary lipids (HADL) model, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that serve to maintain cell membrane fluidity and hence optimal cell function."
3/ Later in the abstract: "Hence, circulating levels of LDL cholesterol may change for nonpathological reasons. Accordingly, an SFA-induced raise in LDL cholesterol in healthy individuals could represent a normal rather than a pathologic response."
Read 15 tweets
18 Jan
1/ Thread — #EatingWindowExperiment initial thoughts...

(If you need a primer, see the experiment design here: cholesterolcode.com/eating-window-…)

All in all, this turned out pretty well. Yes, I had to amend in tighter fasting window timing after the first day....
2/ Going from evening to midday was a very meaningful change with regard to how challenging it would be.

(For details on that, see cholesterolcode.com/eating-window-…)

I normally don’t like fasting more than 14 hours. But this window of 10am-2pm (3 meals) was surprisingly easy.
3/ I think the key was to intentionally eat enough calories that would have normally been over the course of a day anyway. That said, I might have been able to further restrict how much I eat in the last meal (2pm).
Read 8 tweets
27 Nov 20
1/ Someone recently tweeted that hospital food is unhealthy, but that they aren't going to change lifelong habits, thus showcasing photos of this isn't very helpful.

That's actually lingered with me for several days. Maybe because I feel exactly the opposite...
2/ Very little demonstrates the emphasis of nutrition as the food you serve under one's care. If we already know how much diet impacts the very disease that brings people to the hospitals (and we do), why -- of all places -- would we want to enable this negative outcome there?
3/ I've seen countless people adopt healthy habits when simply provided the knowledge and opportunity to do so. What better place to build on this than one dedicated to your returning you to health? At the barest of minimums, the patient should have a choice.
Read 4 tweets
18 Oct 20
1/ 😁Thread -- About Me -- 5 year update😁

It's been a busy 24 hours since @joerogan's podcast dropped where @CarnivoreMD discussed our work (mega thx, Paul!). There's been a surge of new followers, so I figured it was high time to do an update for those just tuning in...
2/ I'm a senior software engineer and systems architect having developed a variety of platforms over my career.

Five years ago next month I saw my cholesterol levels skyrocket on a ketogenic diet and was extremely interested as to the mechanisms behind it...
3/ I began learning everything I could about Lipidology and the system that moves #cholesterol around in our body. To my surprise, it has many structural things in common with a network (a very advanced one, mind you), but soon I was manipulating my own lipid levels easily.
Read 20 tweets
29 Sep 20
1/ Thread -- Let's Get the Data

Many medical professionals (like my good friend and colleague, @DrNadolsky) feel strongly that #LowCarb-ers may be acting very recklessly by allowing their #LDL #Cholesterol to be much higher than the guidelines allow.

citizensciencefoundation.org/concerned-for-…
2/ And this may well be the case.

Certainly if "diet induced" high LDL is the equivalent to genetically high LDL, such as those with #FamilialHypercholesterolemia (FH), then there should be likewise rapidly progressing #atherosclerosis.
3/ "The sine qua non of FH is severe elevation of total and LDL cholesterol levels." jaoa.org/article.aspx?a…

Often heterozygous FH is considered where LDL is 190 to 500 mg/dL, with homozygous being above 500.
Read 14 tweets

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