1/ So I did my 3D body scan this morning (and no, not posting pictures or sharing absolute numbers).

This will have been 5 days since isocaloric carb swapping in low-ish carb for keto.

Waist +0.9"
Stomach +1.2"
Hip +0.4"

Wow... in 5 days? This was pretty unexpected...
2/ Just a reminder-- this is the most controlled experiment between phases I've had to date. Replicated sleep and exercise timing and patterns, even water quantity and consumption window.

Given this shorter time span for the phase, I wasn't expecting much difference to emerge...
3/ Although, to be sure, both my wife and I noticed I was putting on more weight in the midsection even before the scan. I'm holding at around 199.6 for two days in a row, so while I gained around 2.5lbs initially, it seems to have leveled off.
4/ And yes, I'm sure most of this gain is in glycogen and water, but entirely. And frankly, I figured it would be a bit more distributed, but the 3D scan says otherwise.

(Kinda gives a new meaning to "area under the curve")
5/ It's worth emphasizing I don't have dog in the battle over carbs vs fat, etc, even if I do enjoy a low carb diet. Moreover, the Good Scientist in me considers there are many other explanations than "it's simply the carbs", of course (which I won't cover in this thread)
6/ All that said, it is inspiring me to have an even more controlled isocaloric carb-swap experiment. Comparable to this one, I'd swap in, say, 10% carbs to replace the likewise calories of fat in the control phase. I might even do a double crossover.
7/ I'd keep all food the same save the fat vs carb intervention, which I may just need to drink along with the meal in a shake, perhaps...?

I'd add DEXAs at the end of each phase and ideally, I might have a more advanced bioimpedance scale to go along with the 3D scans.
8/ What do you think?

Let's say I tightly control everything as I like to do and perform a double crossover experiment as I describe above.

Would the isocaloric carb swap intervention phases have any significant impact on weight and fat mass beyond glycogen and water retention?

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More from @DaveKeto

21 Jan
1/ Well... this is awkward...

I'm gaining weight on my "bonus" carb-swap phase in spite of it being isocaloric and everything else being nearly identical (exercise, sleep, supplements, even liquid consumption) w/ prior keto phases.

And I'm gaining it pretty fast, actually...
2/ And actually, the "low carb" phase is technically slightly lower in calories than the keto phase.

And this experiment is as controlled as I get
- Fixed eating times with fixed meals (9am/2pm/7pm)
- Fixed exercise (walking) with same route and time (~3pm)
- Comparable sleep
3/ Sure -- like many reading this, I'd assume this is in large part glycogen and water gain. But I'll concede this is impressively fast given I'm at maintenance level of calories -- which was literally just demonstrated in the run-up phases before this one.
Read 4 tweets
20 Jan
1/ #ReadingThread

This paper by @zinocker, @kariannesve, @simondankel is proving an interesting read. Before I get too much further, I'm going to turn it into a "reading thread" and post some of these quotes as I go...

(Big hat tip to @bigfatsurprise) academic.oup.com/ajcn/advance-a…
2/ "In this paper we propose a novel model, the homeoviscous adaptation to dietary lipids (HADL) model, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that serve to maintain cell membrane fluidity and hence optimal cell function."
3/ Later in the abstract: "Hence, circulating levels of LDL cholesterol may change for nonpathological reasons. Accordingly, an SFA-induced raise in LDL cholesterol in healthy individuals could represent a normal rather than a pathologic response."
Read 15 tweets
20 Jan
1/ Some preliminary data from the #EatingWindowExperiment while we wait for the labs to come back.

These are the mean avgs for each period taken over the last 3 days of each phase (wake/7am/9am/2pm/7pm/10pm) compared.

Needless to say, this is some fascinating stuff...
2/ I was taking glucose and ketones (BHB) via @KetoMojo, lipids via CardioChek from @ptsdiagnostics

Where my test and meal times were the same, I'd take the blood test just before the meal.

(For study design, see cholesterolcode.com/eating-window-…)
3/ Again, I'm eating exactly the same thing in each phase, exercising the same, sleeping the same, etc -- the only difference is in the 10.5hr window my meals are 5 hours apart. In the 4.5hr window my meals are 2 hours apart.

(I added the 0.5 to reflect eating time of last meal)
Read 9 tweets
18 Jan
1/ Thread — #EatingWindowExperiment initial thoughts...

(If you need a primer, see the experiment design here: cholesterolcode.com/eating-window-…)

All in all, this turned out pretty well. Yes, I had to amend in tighter fasting window timing after the first day....
2/ Going from evening to midday was a very meaningful change with regard to how challenging it would be.

(For details on that, see cholesterolcode.com/eating-window-…)

I normally don’t like fasting more than 14 hours. But this window of 10am-2pm (3 meals) was surprisingly easy.
3/ I think the key was to intentionally eat enough calories that would have normally been over the course of a day anyway. That said, I might have been able to further restrict how much I eat in the last meal (2pm).
Read 8 tweets
27 Nov 20
1/ Someone recently tweeted that hospital food is unhealthy, but that they aren't going to change lifelong habits, thus showcasing photos of this isn't very helpful.

That's actually lingered with me for several days. Maybe because I feel exactly the opposite...
2/ Very little demonstrates the emphasis of nutrition as the food you serve under one's care. If we already know how much diet impacts the very disease that brings people to the hospitals (and we do), why -- of all places -- would we want to enable this negative outcome there?
3/ I've seen countless people adopt healthy habits when simply provided the knowledge and opportunity to do so. What better place to build on this than one dedicated to your returning you to health? At the barest of minimums, the patient should have a choice.
Read 4 tweets
18 Oct 20
1/ 😁Thread -- About Me -- 5 year update😁

It's been a busy 24 hours since @joerogan's podcast dropped where @CarnivoreMD discussed our work (mega thx, Paul!). There's been a surge of new followers, so I figured it was high time to do an update for those just tuning in...
2/ I'm a senior software engineer and systems architect having developed a variety of platforms over my career.

Five years ago next month I saw my cholesterol levels skyrocket on a ketogenic diet and was extremely interested as to the mechanisms behind it...
3/ I began learning everything I could about Lipidology and the system that moves #cholesterol around in our body. To my surprise, it has many structural things in common with a network (a very advanced one, mind you), but soon I was manipulating my own lipid levels easily.
Read 20 tweets

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