BREAKING—Germany 🇩🇪 has now formally demanded that EU block all export of #COVID19 vaccines produced within the EU.
2) It is due to a huge slowdown in vaccine supplies and delivery backlog in EU. Many countries are now receiving just half or even 40% of doses they were promised. google.com/amp/s/www.bbc.…
3) EU is pissed... extremely pissed at AstraZeneca for reneging on contracts to delivery vaccines. This is EU’s health commissioner....
4) “German Health Minister Jens Spahn backed her call, saying: "This is not about EU first, this is about Europe's fair share." Angela Merkel told the virtual version of annual World Economic Forum, usually held in Davos, there should be a "fair distribution" across the world.
5) “European Commission chief Ursula von der Leyen earlier told forum: "Europe invested billions to help develop the world's first Covid-19 vaccines. And now, the companies must deliver. They must honour their obligations."
6) The row could affect supplies to the UK of the Pfizer-BioNTech vaccine.
UK's Minister for Covid Vaccine Deployment said on Tuesday that supplies were "tight" and warned against "the dead end of vaccine nationalism", adding: "No-one is safe until the whole world is safe."
7) this is real.
8) meanwhile... America just secured 100 million more vaccine doses by invoking Defense Production Act this week (including the lipid nanoparticles to make the mRNA vaccine).
9) US contracts meanwhile... sanofi’s own vaccine is delayed. But they indicated they might switch to producing Pfizer / BioNTech vaccine.

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More from @DrEricDing

28 Jan
BREAKING—Novavax says its #COVID19 vaccine is 90% effective, but likely only 50% against the #B1351 variant found in South Africa.

50% better than 0%, but clearly we have challenges with the #B1351 mutation. UPDATES COMING.
nytimes.com/2021/01/28/hea…
2) SURPRISING—“Participants were infected with the variant even after they had already had Covid.” This aligns with what South Africa CDC warned last week
3) “we are the first to conduct an efficacy trial — in the face of a changing virus,” said Stanley Erck, CEO of Novavax. He said that researchers expected variants could change the trial results, but “the amount of change has been a bit of a surprise to everyone.”
Read 14 tweets
28 Jan
BREAKING—First two community transmission cases of the worrisome #SARSCoV2 strain #B1351 first seen in South Africa 🇿🇦 have been detected in South Carolina. No travel history in either cases. #B1352 is the one seen to evade antibodies. #COVID19
cnn.com/2021/01/28/hea…
2) The variant -- also known as B.1.351 -- has raised concerns over being more transmissible than other versions of the virus, and potentially evading the immune protection offered by antibodies. Experts say they believe vaccines will still be effective against the variant.
3) "The arrival of the SARS-CoV-2 variant in our state is an important reminder to all South Carolinians that the fight against this deadly virus is far from over," Dr. Brannon Traxler, the health department's interim public health director, said in a statement Thursday.
Read 4 tweets
28 Jan
My god—frontline immigrant healthcare workers in hospitals in U.K. who don’t have an NHS health number are being DENIED #COVID19 vaccines by 🇬🇧 government. They treat COVID patients daily!!!

Boris Johnson is like the Donald Trump of the U.K.
2) yes they are similar. newstatesman.com/politics/uk/20…
3) 'They call him Britain Trump' bbc.co.uk/news/world-us-…
Read 4 tweets
28 Jan
Does neuroinvasion of the brain by #SARSCoV2 happen? Not just in mice, but in *humans*? The clear answer in this study is yes — both demonstrated with human brain cells and brain 🧠 inspection of deceased #COVID19 patients. 🧵 from a peer reviewed paper.
ncbi.nlm.nih.gov/pmc/articles/P… Image
2) Let’s first read the abstract:

📌”using human brain organoids... clear evidence of infection”

📌”neuroinvasion can be blocked”

📌”in autopsies of patients who died of COVID19... we detect #SARSCoV2 in neurons”

📌”neuroinvasive capacity of #SARSCoV2Image
3) Conclusions from main discussion summary:

📌”results suggest that neurological symptoms associated with COVID-19 may be related to consequences of direct viral invasion of the central nervous system”

📌”brain is a site for high replicative potential for SARS-CoV-2.” Image
Read 13 tweets
28 Jan
WORRISOME MATH—#B117 variant is so crazy: what happens if there are just 10 cases now, & new 🇬🇧 #B117 has 50%⬆️ transmissibility?

📌1000+ daily cases on Mar23

📌2000+ daily cases on Mar31

This doesn’t include schools reopening or vaccines.

(HT @GosiaGasperoPhD) #COVID19 Image
2) Notably, the virus is such a beast—suppose we have 1000 cases/day now... with an R=0.86 we could reduce it to 500/day in 2 weeks.

➡️But w/ added contagiousness of B117 variant that has ~60% higher R, in 2 weeks, we’d have 3000 new cases/day—3x! 6x vs old

HT @GosiaGasperoPhD Image
3) Denmark 🇩🇰 CDC has modeled this as well... and it’s horrendous. Denmark sequences EVERY SINGLE CASE EACH WEEK for mutations and they know it’s increasing 70% per week!!! Earlier modeling:
Read 13 tweets
28 Jan
HYDROXYCHLOROQUINE drama—Oklahoma Attorney General is attempting to return a $2 million stockpile of HCQ—drug once touted by Trump as way to treat #COVID19. OK criticized for $2 million purchase, a move to curry favor with Trump. HCQ work for COVID? No! 🧵
readfrontier.org/stories/oklaho… Image
2) I feel like I’ve spend years of my life debunking HCQ.

Master thread 🧵 below.
3) the RECOVERY trial not only found no benefit, but the risk was leaning even towards higher risk.
Read 5 tweets

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