In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time
2/18
Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.
3/18
Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).
4/18
France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.
5/18
Portugal has 30 new sequences (orange), most of which are separate introductions, but some do connect with previous sequences.
Norway has 10 new sequences (yellow). Most of these seem to be separate introductions.
6/18
There are 10 new sequences from South Korea (yellow). These are separate introductions, but some of the new seqs cluster, which could indicate local transmission or a common exposure source.
7/18
Germany has 9 new sequences (orange & yellow), which indicate separate introductions.
8/18
The USA has 123 new sequences (orange & yellow). Many of these do cluster with older sequences and seem to indicate ongoing local transmission.
9/18
Switzerland has 30 new sequences (yellow & orange), many of which indicate separate introductions.
10/18
India has 3 new sequences (yellow). These connect to older sequences, which may indicate local transmission or a common exposure source.
11/18
United Arab Emirates has 21 sequences for the first time. Many show independent introductions, but some form a large cluster that is likely local transmission.
12/18
The Czech Republic has 10 sequences for the 1st time and Austria has 41 sequences for the 1st time.
All the Czech & many of the Austrian seqs fall in 1 cluster each, likely indicating local transmission. These clusters are near each other & connected to Slovakian seqs.
13/18
In 501Y.V2, there are new sequences from Germany, Denmark, Spain, the United Arab Emirates, and Belgium.
14/18
Germany has 4 new sequences (yellow & orange). Some indicate a new introduction, others link to an older sequence.
15/18
United Arab Emirates has 5 sequences for the first time, showing multiple introductions.
16/18
Belgium has 6 sequences for the first time, showing multiple introductions.
Denmark and Spain also have sequences for the first time.
17/18
As always, the country plot table is now updated - as usual, be careful interpreting, as sequencing is often still biased toward "S-drop-out" & S:N501 samples, meaning frequencies are not representative.
We're hoping to make this a one-stop location to track not only the 'headline' variants, but many different #SARSCoV2 mutations & variants that scientists are keeping an eye on.
Let's take a tour of the site!
1/12
The buttons on the left will take you to pages focused on key variants & mutations, while the menu at the top will help you jump between info pages (FAQ) & pages compiling together information about many variants (ex: Per country).
Let's take a look at the 20A.EU1 page
2/12
Here, we can
- Click through to a dedicated @nextstrain build for the variant (1)
- See a list of the defining mutations (2)
- Learn a bit about the variant & see links to papers (3)
- See a distribution of 20A.EU1 per country (4)
- See a protein model! (pic 2)
As we head deeper into 2021, a gentle reminder to double-check your #SARSCoV2 sequencing scripts for hardcoded '2020's! 😬
We've seen a real uptick recently in sequences with sampling dates in Jan 2020, with divergence that clearly indicates they meant 2021! 📅🤦🏻♀️
"How can we tell?" you might wonder. Actually, these cases are pretty easy to spot!
Let's take a look at two sequences reported as being from Jan 2020 - 1 in green, 2 in blue. (Spoiler, green is the imposter.)
This view is 'date view' where sequences are plotted on the X-axis by the date they were sampled. Then, we try and infer how they're connected using their genetic information - specifically, what mutations they share & don't share.
3 seqs indicated in red are apparently from the hospital. They're coloured by deletion at position 69, which likely caused them to be flagged (501Y.V1 has it too). However, they're related to other sequences in Germany & Turkey, also w the deletion.
We do see the 69/70 deletion has appeared independently previously. While this is interesting, I don't think it increases concern significantly about this group of sequences, which are part of a larger cluster that's been circulating in Germany since spring 2020.
There are 394 new non-UK sequences in 501Y.V1 from the Netherlands, Denmark, Singapore, Australia, Italy, Spain, France, Ireland, Finland, Sweden, the USA, Switzerland, India, Brazil, Slovakia, & Belgium
A #SARSCoV2 variant with a combination of mutations in Spike (S13I, W152C, L452R) has been making headlines & twitter rounds today, so - a fresh-from-the-oven 🥖 S:L452R focal build is now up - let's take a look:
Importantly, we *don't yet know* if this variant is being pulled along with a general rise in cases, or some other environmental or behavioural change - or whether the mutations change the behaviour of the virus, like transmissibility.
The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.
The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).
There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.
2/16
Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.